{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:43:12Z","timestamp":1755798192785,"version":"3.44.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY023633-01A1, P30EY002687, P30EY001792, EY01792"],"award-info":[{"award-number":["EY023633-01A1, P30EY002687, P30EY001792, EY01792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although it is often reported that adenovirus is the most common etiology for infectious conjunctivitis, a recent multi-center clinical study found that adenovirus was confirmed by polymerase chain reaction in only 16% of cases presenting with acute conjunctivitis. Here, we investigated the hypothesis that a member of Herpesviridae could be the underlying etiology in some non-adenoviral cases of conjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Molecular assays for Herpes Simplex 1 and 2 (HSV-1, HSV-2) and Human Herpesvirus 6A, 6B and 7 (HHV-6A, HHV-6B, HHV-7) were performed on conjunctival samples collected from 18 individuals with acute conjunctivitis and during their recovery in follow-up visits that spanned up to 3 weeks. All samples, obtained from individuals enrolled in a clinical trial evaluating a conjunctivitis treatment, were from eyes that had previously tested negative for adenovirus using polymerase chain reaction (PCR) techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 160 PCR assays were performed on 40 conjunctival samples. Four of these samples, obtained from four different individuals, tested positive for HHV-7. None of the samples tested positive for HSV-1, HSV-2, HHV-6A or HHV-6B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This data provides further evidence that Human Herpesvirus 7 can be present in the eye, as HHV-7 was detected in a subset of conjunctival samples obtained from individuals recovering from non-adenoviral conjunctivitis. Clinicians should consider non-adenoviral etiologies when managing conjunctivitis that presents as classic \u2018pink eye\u2019.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2025.1641991","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T04:10:41Z","timestamp":1755576641000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of human herpesvirus 7 in conjunctival samples collected from individuals recovering from conjunctivitis"],"prefix":"10.3389","volume":"5","author":[{"given":"Andrew T.E.","family":"Hartwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina E.","family":"Morettin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer 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