{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:54Z","timestamp":1788239814312,"version":"build-2803163510"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Selective Laser Trabeculoplasty (SLT) is utilized in cases of primary and certain secondary open-angle glaucoma to decrease intraocular pressure (IOP). SLT effectiveness has been demonstrated in patients with increased IOP secondary to intraocular steroids. In addition to intravitreal steroids, intravitreal anti-vascular endothelial growth factor (VEGF) injections are commonly used in patients with diabetic retinopathy and age-related macular degeneration. Some patients receiving anti-VEGF injections experience increases in IOP. No studies have evaluated the effectiveness of SLT for anti-VEGF-associated glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, single-center study. Anti-VEGF-associated IOP increase was defined as an eye receiving at least one anti-VEGF intravitreal injection prior to SLT. IOP and the number of pressure-lowering drops were measured at 3-, 6-, 9-, and 12-month post-SLT follow-up appointments. Outcomes included changes in IOP, and the number of IOP-lowering drops prescribed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three eyes from 18 patients were included in this study. The IOP was 18.26 \u00b1 3.33 with 2.6 \u00b1 1. drops prescribed at baseline. Two eyes required repeat SLT. Over the study period, IOP was reduced by 3 to 4.5\u00a0mm Hg, with all p-values &amp;lt;0.001. Eight eyes in the study were drop-na\u00efve (no IOP-lowering drops prescribed prior to SLT). Of these, 6\/8 (75%) remained drop-free at the end of the observation period. At their final clinic visit, 78.3% of patients were controlled on SLT without further surgical or medical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first study to demonstrate the long-term effectiveness of SLT in anti-VEGF-associated open-angle glaucoma in steroid-na\u00efve eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2026.1675048","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:37Z","timestamp":1788236797000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective laser trabeculoplasty for anti-VEGF associated intraocular pressure elevation in steroid-na\u00efve eyes"],"prefix":"10.3389","volume":"6","author":[{"given":"Anindya","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center","place":["Lubbock, TX, United States"]},{"name":"Department of Ophthalmology, Baylor College of Medicine","place":["Houston, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey","family":"Krambeer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center","place":["Lubbock, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addie","family":"Flowers","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center","place":["Lubbock, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center","place":["Lubbock, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000050872","article-title":"Intraocular pressure response to selective laser trabeculoplasty in the treatment of primary open-angle glaucoma","volume":"215","author":"Gracner","year":"2001","journal-title":"Ophthalmologica"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2004.00839.x","article-title":"Five-year follow up of selective laser trabeculoplasty in Chinese eyes","volume":"32","author":"Lai","year":"2004","journal-title":"Clin Exp Ophthalmol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32213-x","article-title":"Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial","volume":"393","author":"Gazzard","year":"2019","journal-title":"Lancet"},{"key":"B4","article-title":"Effects of selective laser trabeculoplasty treatment in steroid-induced glaucoma","volume":"116","author":"Tokuda","year":"2012","journal-title":"Nihon Ganka Gakkai Zasshi"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0b013e318031676c","article-title":"The effect of selective laser trabeculoplasty on intraocular pressure in patients with intravitreal steroid-induced elevated intraocular pressure","volume":"17","author":"Rubin","year":"2008","journal-title":"J Glaucoma"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3439182","article-title":"The effect of selective laser trabeculoplasty on intraocular pressure in patients with dexamethasone intravitreal implant-induced elevated intraocular pressure","volume":"2020","author":"Bennedjai","year":"2020","journal-title":"J Ophthalmol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05725-3","article-title":"Use of selective laser trabeculoplasty as an alternative in patients who developed ocular hypertension after intravitreal dexamethasone implants: a series of 35 eyes","volume":"260","author":"Billant","year":"2022","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.027","article-title":"Prophylactic selective laser trabeculoplasty in the prevention of intraocular pressure elevation after intravitreal triamcinolone acetonide injection","volume":"152","author":"Bozkurt","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.08.008","article-title":"The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: a review","volume":"63","author":"Bracha","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.029","article-title":"Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials","volume":"121","author":"Bakri","year":"2014","journal-title":"Ophthalmology"},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1097\/IJG.0000000000001894","article-title":"Intraocular pressure elevation following intravitreal anti-VEGF injections: short and long-term considerations","volume":"30","author":"Levin","year":"2021","journal-title":"J Glaucoma"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0b013e3181ca74de","article-title":"In vitro effects of antivascular endothelial growth factors on cultured human trabecular meshwork cells","volume":"19","author":"Kahook","year":"2010","journal-title":"J Glaucoma"},{"key":"B13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1097\/iae.0b013e31816c6868","article-title":"Intravitreal silicone oil droplets after intravitreal drug injections","volume":"28","author":"Bakri","year":"2008","journal-title":"Retina"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0b013e3181d50cea","article-title":"High-molecular-weight aggregates in repackaged bevacizumab","volume":"30","author":"Kahook","year":"2010","journal-title":"Retina"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.180729","article-title":"Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents","author":"Good","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-010-9410-z","article-title":"Sustained ocular hypertension following intravitreal injections of 0.5 mg\/0.05 ml ranibizumab","volume":"31","author":"Loukianou","year":"2011","journal-title":"Int Ophthalmol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20120618-01","article-title":"Glaucoma filtration surgery following sustained elevation of intraocular pressure secondary to intravitreal anti-VEGF injections","volume":"43","author":"Skalicky","year":"2012","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0b013e31820d7d19","article-title":"Sustained increased intraocular pressure related to intravitreal antivascular endothelial growth factor therapy for neovascular age-related macular degeneration","volume":"21","author":"Tseng","year":"2012","journal-title":"J Glaucoma"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1675048\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:38Z","timestamp":1788236798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1675048\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":18,"alternative-id":["10.3389\/fopht.2026.1675048"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2026.1675048","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"1675048"}}