{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:18:42Z","timestamp":1773202722562,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate intraoperative and postoperative complications and visual acuity (VA) outcomes of cataract surgery in pseudoexfoliation (PEX) eyes compared to non-PEX eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included eyes undergoing phacoemulsification across eight centers in the United Kingdom between July 2003 and March 2015. We categorized these into four groups based on the presence of PEX and other ocular comorbidities. Complications and VA were calculated among each group. Multivariable adjusted models were used to obtain adjusted differences in VA outcomes and adjusted relative risks (RR) of complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>172,008 eyes were included. PEX was present in 1.2% of the study population. PEX eyes had more posterior capsular rupture, zonular dialysis, nucleus drop, and conversion to extracapsular extraction (adjusted RR = 2.3 [95% CI = 1.7 \u2013 3.0], 6.7 [4.9 \u2013 9.0], 2.5 [1.2 \u2013 5.4], and 2.6 [1.03 \u2013 6.3], respectively). Postoperatively, PEX eyes experienced more intraocular pressure \u2265 22 mmHg and IOL dislocation requiring surgical intervention (adjusted RR = 1.6 [1.1 \u2013 2.3] and 7.3 [4.4 \u2013 12.2], respectively). After accounting for the effect of ocular copathology, PEX eyes had similar postoperative VA outcomes (adjusted RR of achieving LogMAR &amp;lt;= 0.3 = 0.99, 95% CI = 0.95 \u2013 1.02) and VA gain \u2265 0.3 logMAR (adjusted RR = 1.05, 95% CI = 0.99 \u2013 1.11) at 4\u201312 weeks, compared to non-PEX eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cataract surgery in PEX has more intraoperative complications, but the visual outcomes were favorable. These findings can inform clinical decision-making and patient counseling in managing cataracts in individuals with PEX.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2026.1687620","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:32:18Z","timestamp":1770874338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cataract surgery outcomes in pseudoexfoliation syndrome: a large multicenter database study"],"prefix":"10.3389","volume":"6","author":[{"given":"Ahmed F.","family":"Shakarchi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences","place":["Little Rock, AR, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed K.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ohio State University","place":["Columbus, OH, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma F.","family":"Shakarchi","sequence":"additional","affiliation":[{"name":"International Committee of the Red Cross (ICRC)","place":["Geneva, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman M.","family":"Elhusseiny","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences","place":["Little Rock, AR, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yit C.","family":"Yang","sequence":"additional","affiliation":[{"name":"Wolverhampton Eye Infirmary, Royal Wolverhampton Hospitals National Health Service (NHS) Trust, New Cross","place":["Wolverhampton, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed B.","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences","place":["Little Rock, AR, United States"]},{"name":"Department of Ophthalmology, Ain Shams University Hospitals","place":["Cairo, Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.007","article-title":"Exfoliative glaucoma: new evidence in the pathogenesis and treatment","volume":"221","author":"Miglior","year":"2015","journal-title":"Prog Brain Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11886-016-0738-5","article-title":"Ocular pseudoexfoliation syndrome linkage to cardiovascular disease","volume":"18","author":"Siordia","year":"2016","journal-title":"Curr Cardiol 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