{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:14:35Z","timestamp":1787764475386,"version":"build-2784847793"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A peripapillary hyperreflective ovoid mass-like structure (PHOMS) is an optical coherence tomography (OCT) specific finding associated with axoplasmic stasis in various optic neuropathies. Its occurrence in arteritic anterior ischemic optic neuropathy (A-AION) has not previously been described, and its prevalence and structural implications across AION subtypes remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp;amp; methods<\/jats:title>\n                    <jats:p>In this exploratory retrospective, age-matched study, patients with A-AION and nonarteritic AION (NA-AION) enrolled in two prior prospective studies between March 2021 and August 2024 were included. All eyes had undergone high-resolution spectral-domain OCT imaging of the optic nerve head as well as visual acuity assessment on first visit of diagnosis. PHOMS was identified according to Optic Disc Drusen Studies (ODDS) Consortium criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two patients (22 eyes) were included, with 11 eyes in each AION subtype. PHOMS was observed in both A-AION and NA-AION. PHOMS was identified in 4 of 11 eyes (36.4%) with A-AION compared with 2 of 11 eyes (18.2%) with NA-AION. The estimated odds ratio for PHOMS presence in A-AION compared with NA-AION was 2.57 (95% CI, 0.36\u201318.33; p = 0.635). Bruch\u2019s membrane opening diameter was similar between groups (A-AION: 1546.78 \u00b1 134.14 \u03bcm; NA-AION: 1507.27 \u00b1 133.95 \u03bcm), while mean peripapillary retinal nerve fiber layer thickness was larger in A-AION than in NA-AION. No differences were observed in macular ganglion cell layer volume, other retinal layer volumes, total retinal volume, or visual acuity between subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The observation of PHOMS across ischemic optic neuropathy subtypes suggests that PHOMS in AION may reflect axoplasmic disturbance related to the ischemic insult itself rather than the underlying disease etiology, although confirmation in larger, prospective studies is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2026.1771903","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:39Z","timestamp":1773379539000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Peripapillary hyperreflective ovoid mass-like structure in arteritic versus nonarteritic anterior ischemic optic neuropathy"],"prefix":"10.3389","volume":"6","author":[{"given":"Marius B.","family":"Maartensson","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Worm","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Stormly","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Lykkebirk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital \u2013 Rigshospitalet","place":["Copenhagen, Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen","place":["Copenhagen, Denmark"]},{"name":"Department of Neuro-Ophthalmology, Rothschild Foundation Hospital","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00976-8","article-title":"Disease stratification in GCA and PMR: state of the art and future perspectives","volume":"19","author":"Tomelleri","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/WNO.0000000000000585","article-title":"The optic disc drusen studies consortium recommendations for diagnosis of optic disc drusen using optical coherence tomography","volume":"38","author":"Malmqvist","year":"2018","journal-title":"J Neuroophthalmol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.036","article-title":"Peripapillary ovoid hyperreflectivity in optic disc edema and pseudopapilledema","volume":"125","author":"Malmqvist","year":"2018","journal-title":"Ophthalmology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1038\/s41598-020-58829-3","article-title":"Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children","volume":"10","author":"Lyu","year":"2020","journal-title":"Sci Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25782","article-title":"Longitudinal development of peripapillary hyper-reflective ovoid masslike structures suggests a novel pathological pathway in multiple sclerosis","volume":"88","author":"Petzold","year":"2020","journal-title":"Ann Neurol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001203","article-title":"Peripapillary hyper-reflective ovoid mass-like structure (PHOMS): an optical coherence tomography marker of axoplasmic stasis in the optic nerve head","volume":"41","author":"Fraser","year":"2021","journal-title":"J Neuroophthalmol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1190279","article-title":"Peripapillary hyper-reflective ovoid mass-like structures (PHOMS): clinical significance, associations, and prognostic implications in ophthalmic conditions","volume":"14","author":"Li","year":"2023","journal-title":"Front Neurol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.03.052","article-title":"Young adults with anterior ischemic optic neuropathy: A multicenter optic disc drusen study","volume":"217","author":"Hamann","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.06.016","article-title":"Optic nerve head anatomy and vascular risk factors in patients with optic disc drusen associated anterior ischemic optic neuropathy","volume":"242","author":"Johannesen","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.13.1.7","article-title":"Features of peripapillary hyperreflective ovoid mass-like structures in nonarteritic anterior ischemic optic neuropathy patients and normal controls","volume":"13","author":"Wang","year":"2024","journal-title":"Transl Vis Sci Technol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"100096","DOI":"10.1016\/j.xops.2021.100096","article-title":"Volumetric measurement of peripapillary hyperreflective ovoid masslike structures in patients with optic disc drusen","volume":"2","author":"J\u00f8rgensen","year":"2022","journal-title":"Ophthalmol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/vision7040072","article-title":"Non-arteritic anterior ischemic optic neuropathy (NA-AION): A comprehensive overview","volume":"7","author":"Salvetat","year":"2023","journal-title":"Vision (Basel)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/17469899.2018.1560265","article-title":"Ocular manifestations of giant cell arteritis","volume":"14","author":"Skanchy","year":"2019","journal-title":"Expert Rev Ophthalmol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14659","article-title":"A novel excel sheet conversion tool from Snellen fraction to LogMAR including \u2018counting fingers\u2019, \u2018hand movement\u2019, \u2018light perception\u2019 and \u2018no light perception\u2019 and focused review of literature of low visual acuity reference values","volume":"99","author":"Moussa","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1379801","article-title":"Peripapillary hyperreflective ovoid mass-like structures: multimodal imaging and associated diseases","volume":"15","author":"Xiao","year":"2024","journal-title":"Front Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/aos.14180","article-title":"Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes","volume":"98","author":"Skougaard","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.preteyeres.2008.11.002","article-title":"Ischemic optic neuropathy","volume":"28","author":"Hayreh","year":"2009","journal-title":"Prog Retin Eye Res"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1771903\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:40Z","timestamp":1773379540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1771903\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":17,"alternative-id":["10.3389\/fopht.2026.1771903"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2026.1771903","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"article-number":"1771903"}}