{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:13:38Z","timestamp":1773389618231,"version":"3.50.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:p>In this case report, we describe a 65-year-old woman who presented to the ophthalmology clinic with vertical binocular diplopia for approximately 2 years. Visual exam was notable for bilateral proptosis and ophthalmoplegia. A computed tomography (CT) of the head revealed bilateral enhancing orbital masses. A biopsy was performed, and the result was positive for epithelial membrane antigen (EMA) and CD34, confirming a diagnosis of perineuroma. To our knowledge, this is the first reported case of bilateral perineuroma of the orbit, a rare location for an already uncommon benign tumor.<\/jats:p>","DOI":"10.3389\/fopht.2026.1777572","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:57Z","timestamp":1773379557000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Bilateral perineuroma of the orbit presenting as vertical binocular diplopia"],"prefix":"10.3389","volume":"6","author":[{"given":"Amanda K.","family":"Hertel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Kansas School of Medicine","place":["Kansas City, KS, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Kansas School of Medicine","place":["Kansas City, KS, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Sokol","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Kansas School of Medicine","place":["Kansas City, KS, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-625-PADAUP","article-title":"Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm","volume":"131","author":"Macarenco","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002730","article-title":"Sclerosing perineurioma of the orbit","volume":"40","author":"Siktberg","year":"2024","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31827a7673","article-title":"Soft tissue perineurioma of the lacrimal gland: a case report","volume":"29","author":"Salter","year":"2013","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31822113c6","article-title":"Orbital perineurioma in the setting of dacryocystitis","volume":"28","author":"Chen","year":"2012","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"6655134","DOI":"10.1155\/2021\/6655134","article-title":"Localized bilateral superior and inferior orbital neurofibroma in the absence of neurofibromatosis","volume":"2021","author":"Rojas-Correa","year":"2021","journal-title":"Case Rep Ophthalmol Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002484","article-title":"Hybrid schwannoma-perineurioma of the orbit","volume":"40","author":"Zhou","year":"2024","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.patol.2022.03.002","article-title":"Hybrid neurofibroma\/schwannoma of the orbit","volume":"56","author":"Salazar-Huayna","year":"2023","journal-title":"Rev Esp Patol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155166.86409.d2","article-title":"Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features","volume":"29","author":"Hornick","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001169","article-title":"Recurrent genomic alterations in soft tissue perineuriomas","volume":"42","author":"Carter","year":"2018","journal-title":"Am J Surg Pathol"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1777572\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:58Z","timestamp":1773379558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1777572\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":9,"alternative-id":["10.3389\/fopht.2026.1777572"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2026.1777572","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"article-number":"1777572"}}