{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:13:27Z","timestamp":1778130807777,"version":"3.51.4"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Poroid hidradenoma (PH) is a rare, benign tumor arising from eccrine sweat glands. It typically presents as a painless and slow-growing subcutaneous lesion in individuals in their sixth to seventh decades of life. Histologically, PH demonstrates neoplastic poroid cells with solid and cystic structures confined to the dermal layer, distinguishing it from other types of eccrine tumors such as eccrine poroma, hidroacanthoma simplex, and dermal duct tumor. It predominantly involves regions abundant in eccrine glands, yet reports involving the eyelids are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a case of an 88-year-old woman with a 2-year history of a non-painful, enlarging mass on her left upper eyelid, associated with irritation and itchiness. Examination revealed a skin-colored, cystic lesion with associated madarosis and minimal telangiectasia. The patient underwent excisional biopsy of the lesion. Histopathological analysis confirmed the diagnosis of PH, characterized by well-circumscribed solid and cystic components with a pseudocapsule. There was no evidence of recurrence at the 3-month follow-up visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the rare occurrence of PH in the eyelids, emphasizing the diagnostic challenges associated with adnexal tumors in atypical locations. Surgical excision remains the standard treatment, and awareness of ocular manifestations of PH is essential for accurate diagnosis and management by ophthalmologists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2026.1806872","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:48:28Z","timestamp":1778129308000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Poroid hidradenoma of the eyelid: a case report"],"prefix":"10.3389","volume":"6","author":[{"given":"Christian","family":"Nieves-Rios","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Puerto Rico","place":["San Juan, Puerto Rico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 J.","family":"L\u00f3pez-Fontanet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Puerto Rico","place":["San Juan, Puerto Rico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Serrano-Olmo","sequence":"additional","affiliation":[{"name":"Department of Pathology, San Pablo Pathology Group","place":["Bayamon, Puerto Rico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, University of Puerto Rico","place":["San Juan, Puerto Rico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000531052","article-title":"Poroid hidradenoma: Case report and comprehensive review of the literature","volume":"15","author":"Brooks","year":"2023","journal-title":"Case Rep Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4103\/0019-5154.198041","article-title":"Poroid hidradenoma: An uncommon cutaneous adnexal neoplasm","volume":"62","author":"Kumar","year":"2017","journal-title":"Indian J Dermatol"},{"key":"B3","article-title":"Neoplasms with eccrine differentiation: Ackermans histologic diagnosis of neoplastic skin diseases: A method by pattern analysis","volume-title":"Neoplasms with Eccrine Differentiation: Ackerman\u2019s Histologic Diagnosis of Neoplastic Skin Diseases: A Method by Pattern Analysis","author":"Abenoza","year":"1990"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31816102c8","article-title":"Poroma of the eyelid","volume":"24","author":"Rabady","year":"2008","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1067\/mjd.2001.110048","article-title":"Poromas of the head and neck","volume":"44","author":"Moore","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/00000372-199604000-00001","article-title":"A call for logic in the classification of adnexal neoplasms","volume":"18","author":"McCalmont","year":"1996","journal-title":"Am J Dermatopathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2021.00101","article-title":"Poroid hidradenoma of the scalp","volume":"22","author":"Min","year":"2021","journal-title":"Arch Craniofac Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1080\/01676830.2021.1939732","article-title":"Eccrine poroma of the eyelid","volume":"43","author":"McCoskey","year":"2024","journal-title":"Orbit"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.4103\/ijo.IJO_666_20","article-title":"Eccrine poroma of the eyelid","volume":"68","author":"Sharma","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.00417.x","article-title":"Eccrine poroma of the eyelid","volume":"29","author":"Vu","year":"2001","journal-title":"Clin Exp Ophthalmol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4103\/ijo.IJO_547_18","article-title":"Eccrine intraepidermal poroma\u00a0of the eyelid","volume":"67","author":"Ahuja","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.60316","article-title":"Eyelid eccrine poroma: A case report and literature review","volume":"16","author":"P\u00e9rez-Trigo","year":"2024","journal-title":"Cureus"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1806872\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:48:44Z","timestamp":1778129324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1806872\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":12,"alternative-id":["10.3389\/fopht.2026.1806872"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2026.1806872","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"article-number":"1806872"}}