{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:41:51Z","timestamp":1777354911779,"version":"3.51.4"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the efficacy of Leptospermum spp (Manuka) honey eye drops in improving dry eye symptoms and reducing ocular inflammation after cataract surgery, compared to sodium hyaluronate eye drops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective controlled study including 53 eyes undergoing cataract surgery was conducted. Patients were consecutively allocated to Manuka eye drops (n = 25) or sodium hyaluronate (n = 28). Subjective symptoms were assessed using the Ocular Surface Disease Index (OSDI) and CATQUEST-SF9 questionnaires. Objective parameters included non-invasive tear break-up time (NIBUT) and conjunctival redness measured with the Keratograph\n                      <jats:sup>\u00ae<\/jats:sup>\n                      5M. Assessments were performed preoperatively and at 1 day, 1 week, and 1 month.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 53 eyes from 53 patients (18 males and 35 females) were analyzed, with a mean age of 72.1 \u00b1 7.6 years. At 1 month, the Manuka group showed a greater reduction in OSDI score compared to the control group (-27.3 \u00b1 20.3 vs -4.3 \u00b1 17.4). After adjustment for baseline OSDI and sex, OSDI remained significantly lower in the Manuka group (adjusted mean difference: -18.7; 95% CI: -28.8 to -8.7; p = 0.007). Conjunctival redness was also lower in the Manuka group at 1 month (adjusted mean difference: -0.56; 95% CI: -0.91 to -0.21; p = 0.014). No significant differences were observed in NIBUT between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Manuka eye drops were associated with greater improvement in postoperative dry eye symptoms and reducing ocular surface inflammation compared to sodium hyaluronate. These findings should be interpreted with caution and considered hypothesis-generating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2026.1812914","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:57:03Z","timestamp":1777352223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Manuka honey eye drops in managing dry eye disease after cataract surgery: a prospective controlled study"],"prefix":"10.3389","volume":"6","author":[{"given":"Javier","family":"Garc\u00eda-Bardera","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garc\u00eda-Bella","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella K.","family":"Cuba-Sulluchuco","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Burgos-Blasco","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Arriola-Villalobos","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"Ben\u00edtez-Del-Castillo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital Clinico San Carlos","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120929958","article-title":"Cataract surgery and dry eye disease: a review","volume":"30","author":"Naderi","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-022-00513-y","article-title":"Prevalence and characteristics of dry eye disease after cataract surgery: a systematic review and meta-analysis","volume":"11","author":"Miura","year":"2022","journal-title":"Ophthalmol Ther"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000569","article-title":"Advances in dry eye disease treatment","volume":"30","author":"O\u2019Neil","year":"2019","journal-title":"Curr Opin Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/foods3030420","article-title":"The composition and biological activity of honey: a focus on Manuka honey","volume":"3","author":"Alvarez-Suarez","year":"2014","journal-title":"Foods"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.138060","article-title":"An updated review of functional ingredients of Manuka honey and their value-added innovations","volume":"440","author":"Wang","year":"2024","journal-title":"Food Chem"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/08164622.2022.2106779","article-title":"Efficacy and safety of manuka honey for dry eye","volume":"106","author":"Hu","year":"2023","journal-title":"Clin Exp Optom"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7066","article-title":"The effects of honey on pro- and anti-inflammatory cytokines: a narrative review","volume":"35","author":"Navaei-Alipour","year":"2021","journal-title":"Phytother Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12524","article-title":"Randomised controlled trial of topical antibacterial Manuka (Leptospermum species) honey for evaporative dry eye due to meibomian gland dysfunction","volume":"100","author":"Albietz","year":"2017","journal-title":"Clin Exp Optom"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12295","article-title":"Standardised antibacterial Manuka honey in the management of persistent post-operative corneal oedema: a case series","volume":"98","author":"Albietz","year":"2015","journal-title":"Clin Exp Optom"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2022.2070505","article-title":"Leptospermum medical grade Manuka honey ointment in the treatment of persistent corneal epithelial defect","volume":"31","author":"Alsarhani","year":"2023","journal-title":"Ocul Immunol Inflammation"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.649030","article-title":"Dry eye and phacoemulsification cataract surgery: a systematic review and meta-analysis","volume":"8","author":"Lu","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/11206721231174060","article-title":"Dry eye and cataract surgery: narrative review and recommendations for management","author":"Villani","year":"2023","journal-title":"Eur J Ophthalmol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31812f67ca","article-title":"Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery","volume":"26","author":"Li","year":"2007","journal-title":"Cornea"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315160","article-title":"Effect of a formulated eye drop with Leptospermum spp honey on tear film properties","volume":"104","author":"Tan","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2019.11.009","article-title":"Randomized masked trial of the clinical efficacy of MGO Manuka honey microemulsion eye cream for the treatment of blepharitis","volume":"18","author":"Craig","year":"2020","journal-title":"Ocular Surface"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.10.001","article-title":"Treatment of contact lens related dry eye with antibacterial honey","volume":"40","author":"Wong","year":"2017","journal-title":"Contact Lens Anterior Eye"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/j.jcrs.0000000000000210","article-title":"Visual function and subjective perception of vision after bilateral implantation of monofocal and multifocal IOLs: a randomized controlled trial","volume":"46","author":"Law","year":"2020","journal-title":"J Cataract Refract Surg"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.ijo_2981_22","article-title":"Tear biomarkers in dry eye disease: progress in the last decade","volume":"71","author":"Kumar","year":"2023","journal-title":"Indian J Ophthalmol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0000000000001638","article-title":"Bulbar redness and dry eye disease: comparison of a validated subjective grading scale and an objective automated method","volume":"98","author":"Schulze","year":"2021","journal-title":"Optom Vis Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-02281-2","article-title":"Repeatability, reproducibility and agreement between three different diagnostic imaging platforms for tear film evaluation of normal and dry eye disease","volume":"37","author":"Singh","year":"2023","journal-title":"Eye"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.766393","article-title":"Meibomian gland morphology changes after cataract surgery: a contra-lateral eye study","volume":"8","author":"Chang","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20140723-01","article-title":"Analysis of surgically induced astigmatism on the posterior surface of the cornea","volume":"30","author":"Nemeth","year":"2014","journal-title":"J Refract Surg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/icu.0000000000000223","article-title":"The location of incision in cataract surgery and its impact on induced astigmatism","volume":"27","author":"Hashemi","year":"2016","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1812914\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:57:04Z","timestamp":1777352224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2026.1812914\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":25,"alternative-id":["10.3389\/fopht.2026.1812914"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2026.1812914","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"article-number":"1812914"}}