{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:46:09Z","timestamp":1782794769705,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:p>\n                    Sturge-Weber Syndrome (SWS) is a rare neurocutaneous disorder characterized by the presence of port-wine stains (PWS) and ophthalmologic complications, including glaucoma and choroidal hemangiomas. These manifestations result from somatic mutations in the\n                    <jats:italic>GNAQ<\/jats:italic>\n                    gene, leading to vascular malformations that affect both the skin and ocular tissues. This review aims to evaluate the impact of laser treatment for PWS on ocular manifestations in SWS, considering both clinical outcomes and underlying biological mechanisms. PWS are common in SWS patients and significantly impair quality of life (QoL) and necessitate effective treatment strategies. Pulsed dye laser (PDL) therapy, which targets the abnormal blood vessels within PWS, has been established as an effective method for reducing the size and appearance of these stains. Clinical studies suggest that PDL therapy not only improves dermatologic outcomes but may also have possible association with ocular vascular dynamics such as reducing intraocular pressure and ameliorating choroidal hemangiomas. The review evaluates data from various studies and highlights changes in intraocular pressure, the incidence of glaucoma, and modifications in choroidal hemangiomas following laser treatment. Mechanistic insights suggest that laser therapy may improve dermatologic and ocular symptoms by modulating sebaceous gland activity and enhancing the skin\u2019s barrier function, thereby indirectly affecting ocular health. Additionally, the review discusses the safety profiles of different laser systems, the importance of multidisciplinary care, and the need for standardized treatment protocols to minimize risks and optimize patient outcomes. Integrated dermatologic and ophthalmologic care remains crucial in improving the overall health and QoL for patients with SWS.\n                  <\/jats:p>","DOI":"10.3389\/fopht.2026.1843605","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:24:40Z","timestamp":1782793480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous laser treatment of port-wine stains and its impact on ocular manifestations in Sturge\u2013Weber syndrome"],"prefix":"10.3389","volume":"6","author":[{"given":"Susan Darby","family":"Keith","sequence":"first","affiliation":[{"name":"Alabama College of Osteopathic Medicine","place":["Dothan, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Herrick","sequence":"additional","affiliation":[{"name":"Alabama College of Osteopathic Medicine","place":["Dothan, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton","family":"Arlen","sequence":"additional","affiliation":[{"name":"The University of Texas at Tyler","place":["Tyler, TX, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halrleen K.","family":"Multani","sequence":"additional","affiliation":[{"name":"Meharry Medical College School of Medicine","place":["Nashville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Frasier","sequence":"additional","affiliation":[{"name":"Northwell Health","place":["New Hyde Park, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Coastal Dermatology & Skin Care Center","place":["Mobile, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Southern Eye Group","place":["Mobile, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5791","article-title":"GNAQ mutation R183Q as a potential cause of familial Sturge-Weber syndrome: a case report","volume":"13","author":"Huang","year":"2017","journal-title":"Oncol Lett"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62702-5.00011-1","article-title":"Sturge-weber syndrome","volume":"132","author":"Comi","year":"2015","journal-title":"Handb Clin Neurol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.05.013","article-title":"Neurological complications of Sturge-Weber syndrome: current status and unmet 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