{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:43:00Z","timestamp":1790815380037,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:p>Current analgesic treatments for Interstitial Cystitis<jats:italic>\/<\/jats:italic>Bladder Pain Syndrome (IC\/BPS) are limited. Here, we propose a novel antinociceptive strategy exploiting the opioid-mediated analgesic properties of T lymphocytes to relieve from bladder pain. In a chronic model of IC\/BPS in rats, we show that a secondary T cell response against intravesically administered ovalbumin prevents from visceral pain in OVA-primed animals. The analgesic effect is associated with the recruitment of T lymphocytes within the inflamed mucosa and is reversed by naloxone-methiodide, a peripheral opioid receptor antagonist. Similarly, intravesical instillation of BCG or tetanus toxoid antigens in vaccinated rats protects from pain in the same model. We show opioid-dependent analgesic properties of local vaccine antigen recall in a preclinical rat model of chronic cystitis. Since BCG bladder instillation is regularly used in humans (as anticancer therapy), our results open it as a new therapeutic positioning for a pain management indication for IC\/BPS patients.<\/jats:p>","DOI":"10.3389\/fpain.2021.642706","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T05:08:29Z","timestamp":1615180109000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pain Management in a Model of Interstitial Cystitis\/Bladder Pain Syndrome by a Vaccinal Strategy"],"prefix":"10.3389","volume":"2","author":[{"given":"C\u00e9line","family":"Aug\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Basso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Blanpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Vergnolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Chabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lluel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.juro.2015.01.086","article-title":"Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment","volume":"193","author":"Hanno","year":"2015","journal-title":"J Urol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.urology.2006.03.084","article-title":"The role of the urinary epithelium in the pathogenesis of interstitial cystitis\/prostatitis\/urethritis","volume":"69","author":"Parsons","year":"2007","journal-title":"Urology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0090-4295(97)00110-6","article-title":"Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis","volume":"50","author":"Hwang","year":"1997","journal-title":"Urology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3978\/j.issn.2223-4683.2015.09.01","article-title":"In what type of interstitial cystitis\/bladder pain syndrome is DMSO intravesical instillation therapy effective?","volume":"4","author":"Tomoe","year":"2015","journal-title":"Transl Androl Urol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5213\/inj.2013.17.2.78","article-title":"Effect of low-dose triple therapy using gabapentin, amitriptyline, and a nonsteroidal anti-inflammatory drug for overactive bladder symptoms in patients with bladder pain syndrome","volume":"17","author":"Kwon","year":"2013","journal-title":"Int Neurourol J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0304-3959(97)00076-6","article-title":"The urogenital and rectal pain syndromes","volume":"73","author":"Wesselmann","year":"1997","journal-title":"Pain."},{"key":"B7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0090-4295(97)00179-9","article-title":"Analysis of long-term Elmiron therapy for interstitial cystitis","volume":"49","author":"Hanno","year":"1997","journal-title":"Urology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12974-017-0804-y","article-title":"Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis","volume":"14","author":"Baddack-Werncke","year":"2017","journal-title":"J Neuroinflammation."},{"key":"B9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12974-016-0591-x","article-title":"Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice","volume":"13","author":"Basso","year":"2016","journal-title":"J. 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