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This review focuses on the following aspects of axial spine pain management in patients with vertebral metastatic disease: (1) pathophysiology and symptoms of cancer- and non-cancer-related spine pain; (2) safety and efficacy of non-interventional rehabilitation approaches to treat this pain; (3) considerations for interventional pain approaches to acute and chronic pain in patients with vertebral metastatic disease. This review also summarizes gaps in the literature and describes specific cases in which the described interventions have been applied.<\/jats:p>","DOI":"10.3389\/fpain.2021.675787","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T06:47:19Z","timestamp":1622789239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Interventional and Non-interventional Medical Rehabilitation Approaches to Axial Spine Pain in Vertebral Metastatic Disease"],"prefix":"10.3389","volume":"2","author":[{"given":"Krishna","family":"Sarma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Kohns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam A.","family":"Berri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"i5","DOI":"10.1093\/nop\/npaa046","article-title":"Epidemiology of spinal cord and column tumors","volume":"7","author":"Wewel","year":"2020","journal-title":"Neuro-Oncol Pract."},{"key":"B2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2147\/CLEP.S28339","article-title":"Estimated number of prevalent cases of metastatic bone disease in the US adult population","volume":"4","author":"Li","year":"2012","journal-title":"Clin Epidemiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ncl.2007.01.004","article-title":"Epidemiology and risk factors for spine pain","volume":"25","author":"Rubin","year":"2007","journal-title":"Neurol Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e720","DOI":"10.1016\/S1470-2045(17)30612-5","article-title":"An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report","volume":"18","author":"Spratt","year":"2017","journal-title":"Lancet Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11914-017-0354-3","article-title":"Bone pain and muscle weakness in cancer patients","volume":"15","author":"Milgrom","year":"2017","journal-title":"Curr Osteoporos Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/bcp.13801","article-title":"Mechanisms that drive bone pain across the lifespan","volume":"85","author":"Mantyh","year":"2019","journal-title":"Br J Clin Pharmacol."},{"key":"B7","first-page":"612","article-title":"Spine pain.","volume-title":"Principles of Rehabilitation Medicine","author":"Chiodo","year":"2019"},{"key":"B8","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.clon.2009.09.023","article-title":"A population-based study of spinal metastatic disease in South-East Norway","volume":"21","author":"Zaikova","year":"2009","journal-title":"Clin Oncol R Coll Radiol G B."},{"key":"B9","doi-asserted-by":"publisher","first-page":"i10","DOI":"10.1093\/nop\/npaa049","article-title":"An overview of the tumors affecting the spine\u2014inside to out","volume":"7","author":"Kumar","year":"2020","journal-title":"Neuro-Oncol Pract."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/os.12552","article-title":"Epidemiological Characteristics of (1196). 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