{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:08:34Z","timestamp":1793848114734,"version":"4.6.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Chronic pain brings complexity to opioid use disorder (OUD). Psychosocial and neurobiological risks for Chronic Pelvic Pain (CPP) and OUD overlap. The primary objective of this exploratory study is to compare sex-specific prevalence of CPP and sexual dysfunction between individuals receiving buprenorphine for OUD and a comparison group receiving treatment for other chronic medical conditions (CMC).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Participants from an OUD treatment (<jats:italic>n<\/jats:italic> = 154) and primary care clinic (<jats:italic>n<\/jats:italic> = 109) completed a survey between July 2019 and February 2020 assessing reproductive and sexual health. Sex<jats:italic>-<\/jats:italic>stratified CPP and pain interference measures were adapted from the Brief Pain Inventory for females, and for males, the Brief Male Sexual Function Inventory and NIH Chronic Prostatitis Symptom Index. The Male and Female Sexual Function Index assessed sexual dysfunction. Prevalence of CPP and sexual dysfunction between groups were compared using Pearson \u03c72 and Fisher's Exact tests.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Participants were 54.4% female and 75.0% Black with almost half having a psychiatric diagnosis. Among OUD females, the highest pain severity reported was for menstrual-related pain, and for OUD males, testicular pain. CPP most interfered with mood in OUD females vs. sleep and enjoyment of life in OUD males. There were no differences in prevalence for global sexual dysfunction with 91.6% of females and 84.2% of males screening positive across groups.<\/jats:p><jats:p><jats:bold>Discussion\/Implications:<\/jats:bold> CPP and sexual dysfunction are important components of wellness and may play a role in OUD recovery trajectories. The value of addressing CPP and sexual dysfunction in tailored comprehensive, sex-informed OUD treatment approaches should be further investigated.<\/jats:p>","DOI":"10.3389\/fpain.2021.787559","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:58:00Z","timestamp":1641877080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Pelvic Pain and Sexual Dysfunction Among Females and Males Receiving Treatment for Opioid Use Disorder"],"prefix":"10.3389","volume":"2","author":[{"given":"Geetika","family":"Reichmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Beth","family":"Parlier-Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhushan","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl","family":"Alappattu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Boissoneault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jsat.2017.03.006","article-title":"Chronic pain among patients with opioid use disorder: results from electronic health records data","volume":"77","author":"Hser","year":"2017","journal-title":"J Subst Abuse Treat."},{"key":"B2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/09540261.2018.1514369","article-title":"Comorbid chronic pain and opioid use disorder: literature review and potential treatment innovations","volume":"30","author":"Speed","year":"2018","journal-title":"Int Rev Psychiatry."},{"key":"B3","doi-asserted-by":"publisher","first-page":"E141","DOI":"10.36076\/ppj.2014\/17\/E141","article-title":"Prevalence of chronic pelvic pain among women: an updated review","volume":"17","author":"Ahangari","year":"2014","journal-title":"Pain Physician."},{"key":"B4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4103\/0970-1591.173105","article-title":"Male chronic pelvic pain: an update","volume":"32","author":"Smith","year":"2016","journal-title":"Indian J Urol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1097\/AOG.0000000000003716","volume":"135","author":"Chronic pelvic pain: ACOG practice","year":"2020","journal-title":"Obstet Gynecol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s11934-008-0055-7","article-title":"Category III chronic prostatitis\/chronic pelvic pain syndrome: insights from the national institutes of health chronic prostatitis collaborative research network studies","volume":"9","author":"Nickel","year":"2008","journal-title":"Curr Urol Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1001\/jama.2021.2631","article-title":"Chronic pelvic pain in women: a review","volume":"325","author":"Lamvu","year":"2021","journal-title":"JAMA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.drugalcdep.2018.04.005","article-title":"Posttraumatic stress disorder and chronic pain are associated with opioid use disorder: results from a 2012-2013 American nationally representative survey","volume":"188","author":"Bilevicius","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"B9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/WNF.0b013e318261e193","article-title":"Co-occurring psychotic and addictive disorders: neurobiology and diagnosis","volume":"35","author":"Ross","year":"2012","journal-title":"Clin Neuropharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nrn2333","article-title":"A common neurobiology for pain and pleasure","volume":"9","author":"Leknes","year":"2008","journal-title":"Nat Rev Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1176\/ajp.145.1.75","article-title":"Relationship of chronic pelvic pain to psychiatric diagnoses and childhood sexual abuse","volume":"145","author":"Walker","year":"1988","journal-title":"Am J Psychiatry."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1097\/AOG.0000000000003267","article-title":"Patterns of prescription opioid use in women with endometriosis: evaluating prolonged use, daily dose, and concomitant use with benzodiazepines","volume":"133","author":"Lamvu","year":"2019","journal-title":"Obstet Gynecol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"107823","DOI":"10.1016\/j.drugalcdep.2019.107823","article-title":"The effect of methadone on the hypothalamic pituitary gonadal axis and sexual function: a systematic review","volume":"207","author":"Ortman","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0972-6748.160930","article-title":"Co-relationship between sexual dysfunction and high-risk sexual behavior in patients receiving buprenorphine and naltrexone maintenance therapy for opioid dependence","volume":"24","author":"Ramdurg","year":"2015","journal-title":"Ind Psychiatry J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fnbeh.2019.00097","article-title":"Sexual functioning and opioid maintenance treatment in women. results from a large multicentre study","volume":"13","author":"Zamboni","year":"2019","journal-title":"Front Behav Neurosci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1176\/appi.ajp.2019.19121284","article-title":"Personalizing the treatment of substance use disorders","volume":"177","author":"Volkow","year":"2020","journal-title":"Am J Psychiatry."},{"key":"B17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-60327-960-4_16","article-title":"Recovery management and the future of addiction treatment and recovery in the USA","volume-title":"Addiction Recovery Management: Current Clinical Psychiatry","author":"Kelly","year":"2010"},{"key":"B18","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ajog.2006.03.081","article-title":"Long-term outcomes after surgical and nonsurgical management of chronic pelvic pain: one year after evaluation in a pelvic pain specialty clinic","volume":"195","author":"Lamvu","year":"2006","journal-title":"Am J Obstet Gynecol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1089\/jwh.2007.1032","article-title":"Self-reported vulvar pain characteristics and their association with clinically confirmed vestibulodynia","volume":"18","author":"Harlow","year":"2009","journal-title":"J Womens Health."},{"key":"B20","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0090-4295(99)80304-5","article-title":"A brief male sexual function inventory for urology","volume":"46","author":"O'Leary","year":"1995","journal-title":"Urology."},{"key":"B21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005392-199908000-00022","article-title":"The national institutes of health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic prostatitis collaborative research network","volume":"162","author":"Litwin","year":"1999","journal-title":"J Urol."},{"key":"B22","first-page":"129","article-title":"Pain assessment: global use of the Brief pain inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singap."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/j.1743-6109.2009.01635.x","article-title":"Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction","volume":"7","author":"Isidori","year":"2010","journal-title":"J Sex Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.eururo.2007.02.046","article-title":"Is the sexual function compromised in long-term testicular cancer survivors?","volume":"52","author":"Dahl","year":"2007","journal-title":"Eur Urol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jsat.2012.12.007","article-title":"Gender differences in a clinical trial for prescription opioid dependence","volume":"45","author":"McHugh","year":"2013","journal-title":"J Subst Abuse Treat."},{"key":"B26","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.addbeh.2011.03.013","article-title":"Characteristics and correlates of men and women with prescription opioid dependence","volume":"36","author":"Back","year":"2011","journal-title":"Addict Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/AOG.0000000000003666","article-title":"Sexual and reproductive health characteristics of women in substance use treatment in michigan","volume":"135","author":"MacAfee","year":"2020","journal-title":"Obstet Gynecol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1001\/jamapsychiatry.2018.2745","article-title":"Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: a randomized clinical trial","volume":"76","author":"Espie","year":"2019","journal-title":"JAMA Psychiatry."},{"key":"B29","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.mehy.2009.10.020","article-title":"Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances","volume":"74","author":"Brower","year":"2010","journal-title":"Med Hypotheses."},{"key":"B30","doi-asserted-by":"publisher","first-page":"140","DOI":"10.22122\/ahj.v12i2.249","article-title":"Crosstalk between sleep disturbance and opioid use disorder: a narrative review","volume":"12","author":"Fathi","year":"2020","journal-title":"Addict Health."},{"key":"B31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.trsl.2021.03.006","article-title":"At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities","volume":"234","author":"Greenwald","year":"2021","journal-title":"Transl Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1055\/s-0036-1597123","article-title":"Relating chronic pelvic pain and endometriosis to signs of sensitization and myofascial pain and dysfunction","volume":"35","author":"Aredo","year":"2017","journal-title":"Semin Reprod Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.drugalcdep.2016.06.024","article-title":"Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy","volume":"166","author":"Tsui","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"B34","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.drugalcdep.2016.04.023","article-title":"Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain","volume":"163","author":"Griffin","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"B35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ejogrb.2010.06.010","article-title":"Female sexual dysfunction","volume":"153","author":"Jha","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B36","first-page":"18","article-title":"Gender and sexual health: sexual dysfunction","volume":"449","author":"Stringer","year":"2016","journal-title":"FP Essent."},{"key":"B37","doi-asserted-by":"publisher","first-page":"108585","DOI":"10.1016\/j.biopha.2019.01.046","article-title":"Male sexual dysfunction: a review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention","volume":"112","author":"Chen","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jsxm.2015.12.015","article-title":"Risk factors for sexual dysfunction among women and men: a consensus statement from the fourth international consultation on sexual medicine 2015","volume":"13","author":"McCabe","year":"2016","journal-title":"J Sex Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12905-018-0602-4","article-title":"Predictors of female sexual dysfunction: a systematic review and qualitative analysis through gender inequality paradigms","volume":"18","author":"McCool-Myers","year":"2018","journal-title":"BMC Womens Health."},{"key":"B40","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/bju.13101","article-title":"Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis\/chronic pelvic pain syndrome: a consensus guideline","volume":"116","author":"Rees","year":"2015","journal-title":"BJU Int"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1007\/s00192-019-03984-z","article-title":"The negative effect of urologic chronic pelvic pain syndrome on female sexual function: a systematic review and meta-analysis","volume":"30","author":"Guan","year":"2019","journal-title":"Int Urogynecol J."}],"container-title":["Frontiers in Pain Research"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2021.787559\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:58:05Z","timestamp":1641877085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2021.787559\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,11]]},"references-count":41,"alternative-id":["10.3389\/fpain.2021.787559"],"URL":"https:\/\/doi.org\/10.3389\/fpain.2021.787559","relation":{},"ISSN":["2673-561X"],"issn-type":[{"value":"2673-561X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,11]]},"article-number":"787559"}}