{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:07:00Z","timestamp":1791266820475,"version":"4.1.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fibromyalgia (FM) is associated with dysfunctional pain modulation mechanisms, including central sensitization. Experimental pain measurements, such as temporal summation (TS), could serve as markers of central sensitization and have been previously studied in these patients, with conflicting results. Our objective in this study was to explore the relationships between two different protocols of TS (phasic and tonic) and test the associations between these measures and other clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cross-sectional analysis of a randomized clinical trial, patients were instructed to determine their pain-60 test temperature, then received one train of 15 repetitive heat stimuli and rated their pain after the 1st and 15th stimuli: TSPS-phasic was calculated as the difference between those. We also administered a tonic heat test stimulus at the same temperature continuously for 30 s and asked them to rate their pain levels after 10 s and 30 s, calculating TSPS-tonic as the difference between them. We also collected baseline demographic data and behavioral questionnaires assessing pain, depression, fatigue, anxiety, sleepiness, and quality of life. We performed univariable analyses of the relationship between TSPS-phasic and TSPS-tonic, and between each of those measures and the demographic and clinical variables collected at baseline. We then built multivariable linear regression models to find predictors for TSPS-phasic and TSPS-tonic, while including potential confounders and avoiding collinearity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty-two FM patients were analyzed. 28.85% developed summation during the TSPS-phasic protocol while 21.15% developed summation during the TSPS-tonic protocol. There were no variables associated TSPS phasic or tonic in the univariable analyses and both measures were not correlated. On the multivariate model for the TSPS-phasic protocol, we found a weak association with pain variables. BPI-pain subscale was associated with more temporal summation in the phasic protocol (\u00df = 0.38, <jats:italic>p<\/jats:italic> = 0.029), while VAS for pain was associated with less summation in the TSPS-tonic protocol (\u00df = \u22120.5, <jats:italic>p<\/jats:italic> = 0.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that, using heat stimuli with pain-60 temperatures, a TSPS-phasic protocol and a TSPS-tonic protocol are not correlated and could index different neural responses in FM subjects. Further studies with larger sample sizes would be needed to elucidate whether such responses could help differentiating subjects with FM into specific phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpain.2022.881543","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:23:06Z","timestamp":1655871786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms"],"prefix":"10.3389","volume":"3","author":[{"given":"Luis","family":"Castelo-Branco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Cardenas-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Rebello-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pacheco-Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S.","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gonzalez-Mego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marduy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vasquez-Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Costa Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo E. P.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleysson","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"McInnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolnei","family":"Caumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat Rev Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"Itc33","DOI":"10.7326\/AITC202003030","article-title":"Fibromyalgia","volume":"172","author":"Bair","year":"2020","journal-title":"Ann Intern Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jpain.2018.01.010","article-title":"Carrillo-de-la-Pe\u00f1a MT. Defective endogenous pain modulation in fibromyalgia: a meta-analysis of temporal summation and conditioned pain modulation paradigms","volume":"19","author":"O'Brien","year":"2018","journal-title":"J Pain."},{"key":"B4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.semarthrit.2014.01.001","article-title":"Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI","volume":"44","author":"Cagnie","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"B5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neuroimage.2015.08.060","article-title":"Pain inhibits pain; human brainstem mechanisms","volume":"124","author":"Youssef","year":"2016","journal-title":"NeuroImage"},{"key":"B6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/BF00376776","article-title":"Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system","volume":"68","author":"Arendt-Nielsen","year":"1994","journal-title":"Eur J Appl Physiol Occup Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain."},{"key":"B8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0304-3959(00)00432-2","article-title":"Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome","volume":"91","author":"Staud","year":"2001","journal-title":"Pain."},{"key":"B9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S1090-3801(98)90031-3","article-title":"The importance of stimulus configuration for temporal summation of first and second pain to repeated heat stimuli","volume":"2","author":"Nielsen","year":"1998","journal-title":"Eur J Pain."},{"key":"B10","doi-asserted-by":"publisher","first-page":"938595","DOI":"10.1155\/2012\/938595","article-title":"Temporal summation of pain is not amplified in a large proportion of fibromyalgia patients","volume":"2012","author":"Potvin","year":"2012","journal-title":"Pain Res Treat."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1097\/j.pain.0000000000000573","article-title":"Pain facilitation and pain inhibition during conditioned pain modulation in fibromyalgia and in healthy controls","volume":"157","author":"Potvin","year":"2016","journal-title":"Pain."},{"key":"B12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0304-3959(02)00053-2","article-title":"Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients","volume":"99","author":"Price","year":"2002","journal-title":"Pain."},{"key":"B13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/JPR.S83352","article-title":"Individually based measurement of temporal summation evoked by a noxious tonic heat paradigm","volume":"8","author":"Suzan","year":"2015","journal-title":"J Pain Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1054\/jpai.2001.25525","article-title":"Effects of age on temporal summation and habituation of thermal pain: clinical relevance in healthy older and younger adults","volume":"2","author":"Edwards","year":"2001","journal-title":"J Pain."},{"key":"B15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.pain.2006.02.003","article-title":"Contact heat-evoked temporal summation: tonic versus repetitive-phasic stimulation","volume":"122","author":"Granot","year":"2006","journal-title":"Pain."},{"key":"B16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s00221-005-0196-6","article-title":"Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness","volume":"170","author":"Nie","year":"2006","journal-title":"Exp Brain Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0304-3959(02)00015-5","article-title":"Gender differences in temporal summation of mechanically evoked pain","volume":"97","author":"Sarlani","year":"2002","journal-title":"Pain."},{"key":"B18","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neucli.2020.06.002","article-title":"Decreased neural inhibitory state in fibromyalgia pain: a cross-sectional study","volume":"50","author":"Uygur-Kucukseymen","year":"2020","journal-title":"Neurophysiol Clin."},{"key":"B19","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1002\/acr.20531","article-title":"Measures of fibromyalgia: Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), Multidimensional Fatigue Inventory (MFI-20), Medical Outcomes Study (MOS) Sleep Scale, and Multiple Ability Self-Report Questionnaire (MASQ)","volume":"63","author":"Williams","year":"2011","journal-title":"Arthritis Care Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/1759720X11416863","article-title":"Simplifying fibromyalgia assessment: the VASFIQ brief symptom scale","volume":"3","author":"Boomershine","year":"2011","journal-title":"Ther Adv Musculoskelet Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1477-7525-8-57","article-title":"Psychometric evaluation of a visual analog scale for the assessment of anxiety","volume":"8","author":"Williams","year":"2010","journal-title":"Health Qual Life Outcomes."},{"key":"B22","first-page":"129","article-title":"Pain assessment: global use of the brief pain inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singap."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar2830","article-title":"The revised fibromyalgia impact questionnaire (FIQR): validation and psychometric properties","volume":"11","author":"Bennett","year":"2009","journal-title":"Arthritis Res Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7525-1-60","article-title":"The Quality of Life Scale (QOLS): reliability, validity, and utilization","volume":"1","author":"Burckhardt","year":"2003","journal-title":"Health Qual Life Outcomes."},{"key":"B25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0272-7358(88)90050-5","article-title":"Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation","volume":"8","author":"Beck","year":"1988","journal-title":"Clin Psychol Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1751-0473-3-17","article-title":"Purposeful selection of variables in logistic regression","volume":"3","author":"Bursac","year":"2008","journal-title":"Source Code Biol Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/diagnostics11020156","article-title":"The search for biomarkers in fibromyalgia","volume":"11","author":"Hackshaw","year":"2021","journal-title":"Diagnostics."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e032710","DOI":"10.1136\/bmjopen-2019-032710","article-title":"Optimised transcranial direct current stimulation (tDCS) for fibromyalgia-targeting the endogenous pain control system: a randomised, double-blind, factorial clinical trial protocol","volume":"9","author":"Castelo-Branco","year":"2019","journal-title":"BMJ Open."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.joca.2020.07.009","article-title":"Effect of exercise on pain processing and motor output in people with knee osteoarthritis: a systematic review and meta-analysis","volume":"28","author":"Hall","year":"2020","journal-title":"Osteoarthritis Cartilage."},{"key":"B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.21801\/ppcrj.2020.63.2","article-title":"Exercise-induced pain threshold modulation in healthy subjects: a systematic review and meta-analysis","volume":"6","author":"Pacheco-Barrios","year":"2020","journal-title":"Princ Pract Clin Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0033-3182(10)70741-6","article-title":"Relationships among pain and depressive and anxiety symptoms in clinical trials of pregabalin in fibromyalgia","volume":"51","author":"Arnold","year":"2010","journal-title":"Psychosomatics."},{"key":"B33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jad.2010.07.004","article-title":"Fibromyalgia syndrome and depressive symptoms: comorbidity and clinical correlates","volume":"128","author":"Aguglia","year":"2011","journal-title":"J Affect Disord."},{"key":"B34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/wvn.12358","article-title":"Becerro-de-Bengoa-Vallejo R, Elena-Losa-Iglesias M, L\u00f3pez-L\u00f3pez D, Rodr\u00edguez-Sanz D, C\u00e1ceres-Le\u00f3n M, et al. Relationship of depression scores and ranges in women who suffer from fibromyalgia by age distribution: a case-control study","volume":"16","author":"Palomo-L\u00f3pez","year":"2019","journal-title":"Worldviews Evid Based Nurs."},{"key":"B35","first-page":"S70","article-title":"Relationship of severity of depression, anxiety and stress with severity of fibromyalgia","volume":"29","author":"Alok","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.neulet.2011.09.033","article-title":"Association between wind-up ratio and central serotonergic function in healthy subjects and depressed patients","volume":"504","author":"Uhl","year":"2011","journal-title":"Neurosci Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"486590","DOI":"10.1155\/2012\/486590","article-title":"Fibromyalgia and depression","volume":"2012","author":"Gracely","year":"2012","journal-title":"Pain Res Treat"},{"key":"B38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jpain.2004.05.007","article-title":"Body pain area and pain-related negative affect predict clinical pain intensity in patients with fibromyalgia","volume":"5","author":"Staud","year":"2004","journal-title":"J Pain."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.3390\/ijms20133130","article-title":"Chronic pain: structural and functional changes in brain structures and associated negative affective states","volume":"20","author":"Yang","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.neuron.2015.06.005","article-title":"Nociception, pain, negative moods, and behavior selection","volume":"87","author":"Baliki","year":"2015","journal-title":"Neuron."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e89086","DOI":"10.1371\/journal.pone.0089086","article-title":"Slow temporal summation of pain for assessment of central pain sensitivity and clinical pain of fibromyalgia patients","volume":"9","author":"Staud","year":"2014","journal-title":"PLoS ONE."},{"key":"B42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-3959(77)90035-5","article-title":"Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses","volume":"3","author":"Price","year":"1977","journal-title":"Pain."},{"key":"B43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/08990229509063142","article-title":"Tonic pain evoked by pulsating heat: temporal summation mechanisms and perceptual qualities","volume":"12","author":"Lautenbacher","year":"1995","journal-title":"Somatosens Mot Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1152\/jn.1997.78.2.992","article-title":"Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode","volume":"78","author":"Vierck CJ","year":"1997","journal-title":"J Neurophysiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0304-3959(03)00159-3","article-title":"Repeated noxious stimulation of the skin enhances cutaneous pain perception of migraine patients in-between attacks: clinical evidence for continuous sub-threshold increase in membrane excitability of central trigeminovascular neurons","volume":"104","author":"Weissman-Fogel","year":"2003","journal-title":"Pain."},{"key":"B46","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.pain.2004.05.009","article-title":"Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls","volume":"110","author":"Staud","year":"2004","journal-title":"Pain."},{"key":"B47","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S1090-3801(02)00087-3","article-title":"Psychophysics of phasic and tonic heat pain stimuli by quantitative sensory testing in healthy subjects","volume":"7","author":"Granot","year":"2003","journal-title":"Eur J Pain."},{"key":"B48","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1213\/00000539-200002000-00031","article-title":"The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans","volume":"90","author":"Guirimand","year":"2000","journal-title":"Anesth Analg."},{"key":"B49","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1213\/00000539-199507000-00013","article-title":"The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study","volume":"81","author":"Arendt-Nielsen","year":"1995","journal-title":"Anesth Analg."},{"key":"B50","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jpain.2005.01.357","article-title":"Effects of the N-methyl-D-aspartate receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal control subjects","volume":"6","author":"Staud","year":"2005","journal-title":"J Pain."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0231124","DOI":"10.1371\/journal.pone.0231124","article-title":"Onset hyperalgesia and offset analgesia: Transient increases or decreases of noxious thermal stimulus intensity robustly modulate subsequent perceived pain intensity","volume":"15","author":"Alter","year":"2020","journal-title":"PLoS ONE."},{"key":"B52","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.pain.2004.01.019","article-title":"Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation","volume":"109","author":"Sarlani","year":"2004","journal-title":"Pain."},{"key":"B53","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.pain.2005.03.025","article-title":"Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain","volume":"115","author":"Lautenbacher","year":"2005","journal-title":"Pain."},{"key":"B54","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/AJP.0000000000000865","article-title":"Pain catastrophizing, self-reported disability, and temporal summation of pain predict self-reported pain in low back pain patients 12 weeks after general practitioner consultation: a Prospective Cohort Study","volume":"36","author":"Petersen","year":"2020","journal-title":"Clin J Pain."},{"key":"B55","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/acr.23266","article-title":"Association between pain sensitization and disease activity in patients with rheumatoid arthritis: a cross-sectional study","volume":"70","author":"Lee","year":"2018","journal-title":"Arthritis Care Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/pm\/pnv074","article-title":"An examination of pain catastrophizing and endogenous pain modulatory processes in adults with chronic low back pain","volume":"17","author":"Owens","year":"2016","journal-title":"Pain Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","article-title":"Sensitization in patients with painful knee osteoarthritis","volume":"149","author":"Arendt-Nielsen","year":"2010","journal-title":"Pain."},{"key":"B58","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s13365-018-0686-5","article-title":"Enhanced facilitation and diminished inhibition characterizes the pronociceptive endogenous pain modulatory balance of persons living with HIV and chronic pain","volume":"25","author":"Owens","year":"2019","journal-title":"J Neurovirol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s12891-021-04306-5","article-title":"Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain","volume":"22","author":"Overstreet","year":"2021","journal-title":"BMC Musculoskelet Disord."},{"key":"B60","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1471-2202-15-42","article-title":"Dall'agnol L, Deitos A, et al. Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome","volume":"15","author":"Vidor","year":"2014","journal-title":"BMC Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1515\/sjpain-2020-0016","article-title":"Pain perception in chronic knee osteoarthritis with varying levels of pain inhibitory control: an exploratory study","volume":"20","author":"Teixeira","year":"2020","journal-title":"Scand J Pain."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e05723","DOI":"10.1016\/j.heliyon.2020.e05723","article-title":"Risk factors of pain, physical function, and health-related quality of life in elderly people with knee osteoarthritis: a cross-sectional study","volume":"6","author":"Tavares","year":"2020","journal-title":"Heliyon."},{"key":"B63","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/pm\/pnab293","article-title":"Electroencephalography signatures for conditioned pain modulation and pain perception in nonspecific chronic low back pain\u2014an exploratory study","volume":"23","author":"Teixeira","year":"2022","journal-title":"Pain Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1038\/s41598-022-04957-x","article-title":"EEG theta and beta bands as brain oscillations for different knee osteoarthritis phenotypes according to disease severity","volume":"12","author":"Simis","year":"2022","journal-title":"Sci Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1093\/brain\/awh098","article-title":"Pain catastrophizing and neural responses to pain among persons with fibromyalgia","volume":"127","author":"Gracely","year":"2004","journal-title":"Brain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1002\/art.39043","article-title":"The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical\/autonomic dysfunction","volume":"67","author":"Kim","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.pain.2010.12.041","article-title":"Pain catastrophizing is related to temporal summation of pain but not temporal summation of the nociceptive flexion reflex","volume":"152","author":"Rhudy","year":"2011","journal-title":"Pain."},{"key":"B68","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/01.ajp.0000210914.72794.bc","article-title":"Pain-related catastrophizing in healthy women is associated with greater temporal summation of and reduced habituation to thermal pain","volume":"22","author":"Edwards","year":"2006","journal-title":"Clin J Pain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1002\/ejp.1348","article-title":"What do you expect? C atastrophizing mediates associations between expectancies and pain-facilitatory processes.","volume":"23","author":"Carriere","year":"2019","journal-title":"Eur J Pain."},{"key":"B70","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jpain.2012.10.007","article-title":"The association of greater dispositional optimism with less endogenous pain facilitation is indirectly transmitted through lower levels of pain catastrophizing","volume":"14","author":"Goodin","year":"2013","journal-title":"J Pain."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jpain.2006.05.009","article-title":"Sex and pain-related psychological variables are associated with thermal pain sensitivity for patients with chronic low back pain","volume":"8","author":"George","year":"2007","journal-title":"J Pain."},{"key":"B72","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/1529-0131(200011)43:11<2493::AID-ANR17>3.0.CO;2-W","article-title":"The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome","volume":"43","author":"Hassett","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B73","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1136\/ard.61.7.644","article-title":"A six year prospective study of a cohort of patients with fibromyalgia","volume":"61","author":"Baumgartner","year":"2002","journal-title":"Ann Rheum Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1177\/1073858409359200","article-title":"Supraspinal pain processing: distinct roles of emotion and attention","volume":"16","author":"Villemure","year":"2010","journal-title":"Neuroscientist."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e934","DOI":"10.1097\/PR9.0000000000000934","article-title":"Intrinsic attention to pain is associated with a pronociceptive phenotype","volume":"6","author":"Adams","year":"2021","journal-title":"Pain Rep."},{"key":"B76","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cophys.2020.01.002","article-title":"Sleep and autonomic nervous system","volume":"15","author":"Zoccoli","year":"2020","journal-title":"Curr Opin Physiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1155\/2014\/536859","article-title":"Autonomic arousal and experimentally induced pain: a critical review of the literature","volume":"19","author":"Kyle","year":"2014","journal-title":"Pain Res Manag."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.2147\/JPR.S267972","article-title":"Multisensory sensitivity is related to deep-tissue but not cutaneous pain sensitivity in healthy individuals","volume":"13","author":"Wang","year":"2020","journal-title":"J Pain Res."}],"container-title":["Frontiers in Pain Research"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2022.881543\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T14:58:52Z","timestamp":1655996332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2022.881543\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":78,"alternative-id":["10.3389\/fpain.2022.881543"],"URL":"https:\/\/doi.org\/10.3389\/fpain.2022.881543","relation":{},"ISSN":["2673-561X"],"issn-type":[{"value":"2673-561X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,22]]},"article-number":"881543"}}