{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:08:10Z","timestamp":1785247690580,"version":"3.55.0"},"reference-count":172,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and complex condition arising from chemotherapy cancer treatments. Currently, there are no treatment or prevention options in the clinic. CIPN accompanies pain-related sensory functions starting from the hands and feet. Studies focusing on neurons <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models significantly advanced our understanding of CIPN pathological mechanisms. However, given the direct toxicity shown in both neurons and non-neuronal cells, effective <jats:italic>in vivo<\/jats:italic> or <jats:italic>in vitro<\/jats:italic> models that allow the investigation of neurons in their local environment are required. No single model can provide a complete solution for the required investigation, therefore, utilizing a multi-model approach would allow complementary advantages of different models and robustly validate findings before further translation. This review aims first to summarize approaches and insights from CIPN <jats:italic>in vivo<\/jats:italic> models utilizing small model organisms. We will focus on <jats:italic>Drosophila melanogaster<\/jats:italic> CIPN models that are genetically amenable and accessible to study neuronal interactions with the local environment <jats:italic>in vivo<\/jats:italic>. Second, we will discuss how these findings could be tested in physiologically relevant vertebrate models. We will focus on <jats:italic>in vitro<\/jats:italic> approaches using human cells and summarize the current understanding of engineering approaches that may allow the investigation of pathological changes in neurons and the skin environment.<\/jats:p>","DOI":"10.3389\/fpain.2022.912977","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T04:54:28Z","timestamp":1657256068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cellular Pathogenesis of Chemotherapy-Induced Peripheral Neuropathy: Insights From Drosophila and Human-Engineered Skin Models"],"prefix":"10.3389","volume":"3","author":[{"given":"Grace Ji-eun","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Erbil","family":"Abaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison Christine","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s13304-016-0359-y","article-title":"Worldwide burden of colorectal cancer: a review","volume":"68","author":"Favoriti","year":"2016","journal-title":"Updates Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends Cancer","volume":"19","author":"Jemal","year":"2010","journal-title":"Epidemiol Biomarkers Prev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1758835918768232","DOI":"10.1177\/1758835918768232","article-title":"First-line treatment of ovarian cancer: questions and controversies to address","volume":"10","author":"Ledermann","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41416-021-01319-8","article-title":"Determining lines of therapy in patients with solid cancers: a proposed new systematic and comprehensive framework","volume":"125","author":"Saini","year":"2021","journal-title":"Br J Cancer."},{"key":"B5","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1183\/09031936.00132008","article-title":"First- and second-line therapy for advanced nonsmall cell lung cancer","volume":"33","author":"Sculier","year":"2009","journal-title":"Eur Respir J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1634\/theoncologist.12-7-785","article-title":"First-line treatment options for patients with HER-2 negative metastatic breast cancer: the impact of modern adjuvant chemotherapy","volume":"12","author":"Verma","year":"2007","journal-title":"Oncologist."},{"key":"B7","doi-asserted-by":"publisher","first-page":"913848","DOI":"10.1155\/2012\/913848","article-title":"Costs and workloss burden of patients with chemotherapy-associated peripheral neuropathy in breast ovarian head and neck and nonsmall cell lung cancer","volume":"2012","author":"Pike","year":"2012","journal-title":"Chemother Res Pract."},{"key":"B8","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nrneurol.2010.160","article-title":"Chemotherapy-induced peripheral neurotoxicity","volume":"6","author":"Cavaletti","year":"2010","journal-title":"Nat Rev Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/cpt.590","article-title":"Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy","volume":"101","author":"Chua","year":"2017","journal-title":"Clin Pharmacol Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"E2189","DOI":"10.1073\/pnas.1525096113","article-title":"Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish","volume":"113","author":"Lisse","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1002\/cncr.31248","article-title":"Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: targeting the source","volume":"124","author":"Ma","year":"2018","journal-title":"Cancer."},{"key":"B12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12885-019-5302-4","article-title":"Are we mis-estimating chemotherapy-induced peripheral neuropathy?","volume":"19","author":"Molassiotis","year":"2019"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain."},{"key":"B14","doi-asserted-by":"publisher","first-page":"4109","DOI":"10.1007\/s10072-021-05576-6","article-title":"Chemotherapy and peripheral neuropathy","volume":"42","author":"Mizrahi","year":"2021","journal-title":"Neurol Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neuropharm.2013.08.016","article-title":"Paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions","volume":"2014","author":"Gornstein","year":"2013","journal-title":"Neuropharmacology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1200\/JCO.20.01399","article-title":"Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update","volume":"38","author":"Loprinzi","year":"2020","journal-title":"J Clin Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"102831","DOI":"10.1016\/j.critrevonc.2019.102831","article-title":"Ehrlich BE of chemotherapy-induced peripheral neuropathy: A review of recent findings","volume":"145","author":"Ibrahim","year":"2020","journal-title":"Crit Rev Oncol Hematol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fnmol.2017.00174","article-title":"Pathophysiology of chemotherapy-induced peripheral neuropathy","volume":"10","author":"Starobova","year":"2017","journal-title":"Front Mol Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1200\/JCO.2005.04.0543","article-title":"Peripheral neuropathy induced by microtubule-stabilizing agents","volume":"24","author":"Lee","year":"2006","journal-title":"J Clin Oncol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3389\/fphar.2013.00156","article-title":"Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)","volume":"4","author":"Han","year":"2013","journal-title":"Front Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.critrevonc.2015.04.011","article-title":"Neuropathy in patients affected by breast cancer: literature review","volume":"96","author":"Iuliis","year":"2015","journal-title":"Crit Rev Oncol Hematol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/j.pain.0000000000000404","article-title":"Chemotherapy-induced pain and neuropathy: a prospective study in patients treated with adjuvant oxaliplatin or docetaxel","volume":"157","author":"Ventzel","year":"2016","journal-title":"Pain."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00520-015-3063-4","article-title":"National cancer institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons","volume":"24","author":"Majithia","year":"2016","journal-title":"Support Care Cancer."},{"key":"B24","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1136\/jnnp-2017-317215","article-title":"Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort","volume":"89","author":"Shah","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1200\/JCO.2013.54.0914","article-title":"Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: american society of clinical oncology clinical practice guideline","volume":"32","author":"Hershman","year":"2014","journal-title":"J Clin Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1001\/jama.2013.2813","article-title":"Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial","volume":"309","author":"Smith","year":"2013","journal-title":"JAMA."},{"key":"B27","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1097\/j.pain.0000000000001798","article-title":"Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress","volume":"161","author":"Ferrari","year":"2020","journal-title":"Pain."},{"key":"B28","doi-asserted-by":"publisher","first-page":"66","DOI":"10.4097\/kjae.2012.62.1.66","article-title":"Gender differences in paclitaxel-induced neuropathic pain behavior and analgesic response in rats","volume":"62","author":"Hwang","year":"2012","journal-title":"Korean J Anesthesiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1158\/1078-0432.CCR-12-3786","article-title":"CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity","volume":"19","author":"Graan","year":"2013","journal-title":"Clin Cancer Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"907","DOI":"10.2217\/bmm-2017-0427","article-title":"Predictive biomarkers of chemotherapy-induced peripheral neuropathy: a review","volume":"12","author":"Diaz","year":"2018","journal-title":"Biomark Med."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12333","article-title":"Overview and critical revision of clinical assessment tools in chemotherapy-induced peripheral neurotoxicity","author":"Park","year":"2019","journal-title":"J Peripher Nerv Syst"},{"key":"B32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/0192623319855969","article-title":"Intraepidermal nerve fiber analysis in human patients and animal models of peripheral neuropathy: a comparative review","volume":"48","author":"Mangus","year":"2020","journal-title":"Toxicol Pathol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1529-8027.2010.00269.x","article-title":"European federation of neurological societies\/peripheral nerve society guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the european federation of neurological societies and the peripheral nerve society","volume":"15","year":"2010","journal-title":"J Peripher Nerv Syst"},{"key":"B34","first-page":"4413","article-title":"Intraepidermal nerve fibre density in cancer patients receiving adjuvant chemotherapy","volume":"31","author":"Koskinen","year":"2011","journal-title":"Anticancer Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/nan.12651","article-title":"The analysis of epidermal nerve fibre spatial distribution improves the diagnostic yield of skin biopsy","volume":"47","author":"Piscosquito","year":"2021","journal-title":"Neuropathol Appl Neurobiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/j.1532-2149.2012.00157.x","article-title":"Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients","volume":"16","author":"Schley","year":"2012","journal-title":"Eur J Pain."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e0145816","DOI":"10.1371\/journal.pone.0145816","article-title":"Identifying Predictors of Taxane-Induced Peripheral Neuropathy Using Mass Spectrometry-Based Proteomics Technology","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS ONE."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1111\/j.1460-9568.2011.07652","article-title":"Terminal arbor degeneration - a novel lesion produced by the antineoplastic agent paclitaxel","volume":"33","author":"Bennett","year":"2011","journal-title":"Eur J Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"626687","DOI":"10.3389\/fimmu.2020.626687","article-title":"Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy","volume":"11","author":"Fumagalli","year":"2020","journal-title":"Front Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/ana.10300","article-title":"WldS mice are resistant to paclitaxel (taxol) neuropathy","volume":"52","author":"Wang","year":"2002","journal-title":"Ann Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.critrevonc.2008.01.008","article-title":"Peripheral nerve damage associated with administration of taxanes in patients with cancer","volume":"66","author":"Argyriou","year":"2008","journal-title":"Crit Rev Oncol Hematol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5054","DOI":"10.1523\/JNEUROSCI.4951-11.2012","article-title":"model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration","volume":"32","author":"Bhattacharya","year":"2012","journal-title":"J Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"dmm032938","DOI":"10.1242\/dmm.032938","article-title":"Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy","volume":"11","author":"Brazill","year":"2018","journal-title":"Dis Model Mech"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1093\/brain\/awab184","article-title":"Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy","volume":"144","author":"Bosanac","year":"2021","journal-title":"Brain."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202106080","article-title":"Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN","author":"Pazyra-Murphy","year":"","journal-title":"J Cell Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1093\/brain\/aww251","article-title":"Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice","volume":"139","author":"Geisler","year":"2016","journal-title":"Brain."},{"key":"B47","doi-asserted-by":"publisher","first-page":"113607","DOI":"10.1016\/j.expneurol.2021.113607","article-title":"Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1 (-\/-) mice","volume":"338","author":"Gould","year":"2021","journal-title":"Exp Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1744806918816462","DOI":"10.1177\/1744806918816462","article-title":"Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors","volume":"14","author":"Kober","year":"2018","journal-title":"Mol Pain"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1744806919878088","DOI":"10.1177\/1744806919878088","article-title":"Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy","volume":"15","author":"Kober","year":"2019","journal-title":"Mol Pain"},{"key":"B50","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12974-021-02098-y","article-title":"Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain","volume":"18","author":"Yin","year":"2021","journal-title":"J Neuroinflammation."},{"key":"B51","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jpain.2019.06.008","article-title":"Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin, and oxaliplatin in C57BL\/6J Mice","volume":"21","author":"Starobova","year":"2020","journal-title":"J Pain."},{"key":"B52","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1523\/JNEUROSCI.2661-18.2018","article-title":"Li Y. Nociceptor translational profiling reveals the ragulator-rag GTPase complex as a critical generator of neuropathic","volume":"39","author":"Megat","year":"2019","journal-title":"Pain J Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.bbi.2014.03.014","article-title":"CX3CL1-mediated macrophage activation contributed to paclitaxel-induced DRG neuronal apoptosis and painful peripheral neuropathy","volume":"40","author":"Huang","year":"2014","journal-title":"Brain Behav Immun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ejphar.2008.07.008","article-title":"The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice","volume":"592","author":"Kiguchi","year":"2008","journal-title":"Eur J Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbi.2015.11.004","article-title":"Upregulation of CCL2 via ATF3\/c-Jun interaction mediated the bortezomib-induced peripheral neuropathy","volume":"53","author":"Liu","year":"2016","journal-title":"Brain Behav Immun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1744-8069-6-76","article-title":"Prevention of paclitaxel-induced allodynia by minocycline: effect on loss of peripheral nerve fibers and infiltration of macrophages in rats","volume":"6","author":"Liu","year":"2010","journal-title":"Mol Pain."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e0170814","DOI":"10.1371\/journal.pone.0170814","article-title":"Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy","volume":"12","author":"Makker","year":"2017","journal-title":"PLoS ONE."},{"key":"B58","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12974-018-1270-x","article-title":"High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats","volume":"15","author":"Meregalli","year":"2018","journal-title":"J Neuroinflammation."},{"key":"B59","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3389\/fnmol.2017.00397","article-title":"The therapeutic potential of monocyte\/macrophage manipulation in the treatment of chemotherapy-induced painful neuropathy","volume":"10","author":"Montague","year":"2017","journal-title":"Front Mol Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.expneurol.2006.07.022","article-title":"Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells","volume":"203","author":"Peters","year":"2007","journal-title":"Exp Neurol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"7032","DOI":"10.1523\/JNEUROSCI.3542-17.2018","article-title":"Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain","volume":"38","author":"Shepherd","year":"2018","journal-title":"J Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1084\/jem.20201452","article-title":"Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-4 \u2264 release","volume":"218","author":"Starobova","year":"2021","journal-title":"J Exp Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3389\/fnins.2019.00653","article-title":"Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy","volume":"13","author":"Starobova","year":"2019","journal-title":"Front Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jpain.2016.02.011","article-title":"Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy","volume":"17","author":"Zhang","year":"2016","journal-title":"J Pain."},{"key":"B65","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1177\/0192623319861937","article-title":"A comparative review of chemotherapy-induced peripheral neuropathy in vivo and in vitro models","volume":"48","author":"Eldridge","year":"2020","journal-title":"Toxicol Pathol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1523\/JNEUROSCI.1479-20.2021","article-title":"Genetic reduction of mitochondria complex I subunits is protective against cisplatin-induced neurotoxicity in drosophila","volume":"42","author":"Groen","year":"2022","journal-title":"J Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/19336934.2019.1565257","article-title":"Drosophila strain specific response to cisplatin neurotoxicity","volume":"12","author":"Groen","year":"2019","journal-title":"Fly (Austin)."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e0239126","DOI":"10.1371\/journal.pone.0239126","article-title":"PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy","volume":"15","author":"Kim","year":"2020","journal-title":"PLoS ONE."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e2012685118","DOI":"10.1073\/pnas.2012685118","article-title":"Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy","volume":"118","author":"Pero","year":"2021","journal-title":"Proc Natl Acad Sci USA."},{"key":"B70","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.nbd.2016.10.003","article-title":"Cisplatin induces mitochondrial deficits in drosophila larval segmental nerve","volume":"97","author":"Podratz","year":"2017","journal-title":"Neurobiol Dis."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.4161\/fly.24789","article-title":"An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in Drosophila melanogaster","author":"Podratz","year":"2013","journal-title":"Fly (Austin)"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006050118","article-title":"Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy","author":"Shin","year":"","journal-title":"P Natl Acad Sci USA"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e0221787","DOI":"10.1371\/journal.pone.0221787","article-title":"Systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN)","volume":"14","author":"Gadgil","year":"2019","journal-title":"PLoS ONE."},{"key":"B74","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/BF00227662","article-title":"Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats","volume":"84","author":"Cavaletti","year":"1992","journal-title":"Acta Neuropathol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"113090","DOI":"10.1016\/j.expneurol.2019.113090","article-title":"Analyzing chemotherapy-induced peripheral neuropathy in vivo using non-mammalian animal models","volume":"23","author":"Cirrincione","year":"2020","journal-title":"Exp Neurol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/jns.12226","article-title":"Pain in chemotherapy-induced peripheral neurotoxicity","volume":"22","author":"Marmiroli","year":"2017","journal-title":"J Peripher Nerv Syst."},{"key":"B77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuroscience.2017.11.047","article-title":"Human vs. mouse nociceptors\u2014similarities and differences","volume":"387","author":"Rostock","year":"2018","journal-title":"Neuroscience."},{"key":"B78","doi-asserted-by":"publisher","first-page":"105391","DOI":"10.1016\/j.nbd.2021.105391","article-title":"Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons","volume":"155","author":"Schinke","year":"2021","journal-title":"Neurobiol Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"e0118020","DOI":"10.1371\/journal.pone.0118020","article-title":"Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells","volume":"10","author":"Wheeler","year":"2015","journal-title":"PLoS ONE."},{"key":"B80","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nn.3886","article-title":"Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts","volume":"18","author":"Wainger","year":"2015","journal-title":"Nat Neurosci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"21889","DOI":"10.1038\/s41598-020-78896-w","article-title":"Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation","volume":"10","author":"Cetinkaya-Fisgin","year":"2020","journal-title":"Sci Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ygyno.2015.11.011","article-title":"Chemotherapy-induced peripheral neuropathy: current status and progress","volume":"140","author":"Brewer","year":"2016","journal-title":"Gynecol Oncol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1124\/jpet.116.235283","article-title":"Identification and characterization of new chemical entities targeting apurinic\/apyrimidinic endonuclease 1 for the prevention of chemotherapy-induced peripheral neuropathy","volume":"359","author":"Kelley","year":"2016","journal-title":"J Pharmacol Exp Ther."},{"key":"B84","doi-asserted-by":"publisher","first-page":"5947","DOI":"10.1038\/s41598-017-05784-1","article-title":"Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms","volume":"7","author":"Imai","year":"2017","journal-title":"Sci Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"e154194","DOI":"10.1172\/jci.insight.154194","article-title":"CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain","volume":"7","author":"Singh","year":"2022","journal-title":"JCI Insight."},{"key":"B86","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jphs.2021.11.003","article-title":"Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy","volume":"148","author":"Domoto","year":"2022","journal-title":"J Pharmacol Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.expneurol.2009.04.017","article-title":"Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration","volume":"218","author":"Yang","year":"2009","journal-title":"Exp Neurol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.expneurol.2016.11.015","article-title":"Mechanisms of paclitaxel are local to the distal axon and independent of transport defects","volume":"288","author":"Gornstein","year":"2017","journal-title":"Exp Neurol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fgene.2019.00051","article-title":"Drosophila melanogaster: a model organism to study","volume":"10","author":"Mirzoyan","year":"2019","journal-title":"Cancer Front Genet."},{"key":"B90","doi-asserted-by":"publisher","first-page":"dmm039032","DOI":"10.1242\/dmm.039032","article-title":"One hundred years of drosophila cancer research: no longer in solitude","volume":"12","author":"Villegas","year":"2019","journal-title":"Dis Model Mech"},{"key":"B91","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0168-9525(99)01878-8","article-title":"Drosophila in cancer research. An expanding role Trends","volume":"16","author":"Potter","year":"2000","journal-title":"Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"dev187534","DOI":"10.1242\/dev.187534","article-title":"Mechanosensory neuron regeneration in adult drosophila","volume":"148","author":"Fernandez-Hernandez","year":"2021","journal-title":"Development"},{"key":"B93","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.nbd.2011.03.022","article-title":"Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity","volume":"43","author":"Podratz","year":"2011","journal-title":"Neurobiol Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"99","DOI":"10.12688\/f1000research.13581.2","article-title":"A fruit fly model for studying paclitaxel-induced peripheral neuropathy and hyperalgesia","volume":"7","author":"Hamoudi","year":"2018","journal-title":"F1000Res"},{"key":"B95","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/wdev.135","article-title":"Development of the embryonic and larval peripheral nervous system of drosophila","volume":"3","author":"Singhania","year":"2014","journal-title":"Wiley Interdiscip Rev Dev Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF00402027","article-title":"Morphological differentiation of the embryonic peripheral neurons in drosophila","volume":"196","author":"Bodmer","year":"1987","journal-title":"Rouxs Arch Dev Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1242\/dev.129.12.2867","article-title":"Tiling of the drosophila epidermis by multidendritic sensory neurons","volume":"129","author":"Grueber","year":"2002","journal-title":"Development."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.cub.2007.11.029","article-title":"Nociceptive neurons protect Drosophila larvae from parasitoid wasps","volume":"17","author":"Hwang","year":"2007","journal-title":"Curr Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.cub.2012.09.019","article-title":"Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae","volume":"22","author":"Tsubouchi","year":"2012","journal-title":"Curr Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1016\/j.cub.2016.09.038","article-title":"The TRP channels Pkd2, nompc, and trpm act in cold-sensing neurons to mediate unique aversive behaviors to noxious cold in drosophila","volume":"26","author":"Turner","year":"2016","journal-title":"Curr Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature11685","article-title":"Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation","volume":"493","author":"Yan","year":"2013","journal-title":"Nature."},{"key":"B102","doi-asserted-by":"publisher","first-page":"4122","DOI":"10.1091\/mbc.e07-10-1079","article-title":"Microtubules have opposite orientation in axons and dendrites of drosophila neurons","volume":"19","author":"Stone","year":"2008","journal-title":"Mol Biol Cell."},{"key":"B103","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.tins.2011.07.004","article-title":"How does morphology relate to function in sensory arbors?","volume":"34","author":"Hall","year":"2011","journal-title":"Trends. Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"E8062","DOI":"10.1073\/pnas.1707467114","article-title":"Space-filling requires a neuronal type-specific extracellular permissive signal in drosophila","volume":"114","author":"Poe","year":"2017","journal-title":"P Natl Acad Sci USA"},{"key":"B105","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jns.2005.11.010","article-title":"Morphological features of nerves in skin biopsies","volume":"242","author":"Wendelschafer-Crabb","year":"2006","journal-title":"J Neurol Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuron.2011.10.033","article-title":"Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in drosophila sensory neurons","volume":"73","author":"Kim","year":"2012","journal-title":"Neuron."},{"key":"B107","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neuron.2011.10.036","article-title":"Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space","volume":"73","author":"HanC Wang","year":"2012","journal-title":"Neuron"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e1005746","DOI":"10.1371\/journal.ppat.1005746","article-title":"Transdifferentiation and proliferation in two distinct hemocyte lineages in drosophila melanogaster larvae after wasp infection","volume":"12","author":"Anderl","year":"2016","journal-title":"PLoS PATHOG."},{"key":"B109","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fimmu.2020.00063","article-title":"Subpopulation of macrophage-like plasmatocytes attenuates systemic growth via JAK\/STAT in the drosophila fat body","volume":"11","author":"Shin","year":"2020","journal-title":"Front Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e54818","DOI":"10.7554\/eLife.54818","article-title":"A single-cell survey of drosophila blood","volume":"9","author":"Tattikota","year":"2020","journal-title":"Elife"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.cell.2016.04.049","article-title":"Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response","volume":"165","author":"Weavers","year":"2016","journal-title":"Cell."},{"key":"B112","doi-asserted-by":"publisher","first-page":"15990","DOI":"10.1038\/ncomms15990","article-title":"Regulation of drosophila hematopoietic sites by activin-beta from active sensory neurons","volume":"8","author":"Makhijani","year":"2017","journal-title":"Nat Commun."},{"key":"B113","doi-asserted-by":"publisher","first-page":"5379","DOI":"10.1242\/dev.067322","article-title":"The peripheral nervous system supports blood cell homing and survival in the drosophila iarva","volume":"138","author":"Makhijani","year":"2011","journal-title":"Development."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.immuni.2019.05.009","article-title":"A subset of skin macrophages contributes to the surveillance and regeneration of local nerves","volume":"50","author":"Kolter","year":"2019","journal-title":"Immunity"},{"key":"B115","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.lfs.2012.07.029","article-title":"Channels and animal behavior","volume":"92","author":"Fowler","year":"2013","journal-title":"Life Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"854124","DOI":"10.3389\/fphys.2022.854124","article-title":"Drosophila as a model to study the mechanism of nociception","volume":"13","author":"He","year":"2022","journal-title":"Front Physiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/224285a0","article-title":"Abnormal electroretinogram from a Drosophila mutant","volume":"224","author":"Cosens","year":"1969","journal-title":"Nature."},{"key":"B118","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.1223899","article-title":"dSarm\/Sarm1 is required for activation of an injury-induced axon death pathway","volume":"337","author":"Osterloh","year":"2012","journal-title":"Science."},{"key":"B119","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.gde.2017.01.011","article-title":"Molecular pathogenesis of peripheral neuropathies: insights from drosophila models","volume":"44","author":"Bussmann","year":"2017","journal-title":"Curr Opin Genet Dev."},{"key":"B120","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/dvdy.22737","article-title":"Pokes, sunburn, and hot sauce: drosophila as an emerging model for the biology of nociception","volume":"241","author":"Im","year":"2012","journal-title":"Dev Dyn."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/S0960-9822(03)00596-7","article-title":"Enhanced locomotion caused by loss of the drosophila DEG\/ENaC protein pickpocket1","volume":"13","author":"Ainsley","year":"2003","journal-title":"Curr Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S0960-9822(03)00207-0","article-title":"Dendrites of distinct classes of drosophila sensory neurons show different capacities for homotypic repulsion","volume":"13","author":"Grueber","year":"2003","journal-title":"Curr Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nmeth.1800","article-title":"Power tools for gene expression and clonal analysis in drosophila","volume":"9","author":"del Valle Rodriguez","year":"2011","journal-title":"Nat Methods"},{"key":"B124","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1126\/science.287.5461.2204","article-title":"Comparative genomics of the eukaryotes","volume":"287","author":"Rubin","year":"2000","journal-title":"Science."},{"key":"B125","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrg1503","article-title":"Drosophila, the golden bug, emerges as a tool for human genetics","volume":"6","author":"Bier","year":"2005","journal-title":"Nat Rev Genet."},{"key":"B126","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0092-8674(03)00272-1","article-title":"Painless, a drosophila gene essential for nociception","volume":"113","author":"Tracey","year":"2003","journal-title":"Cell."},{"key":"B127","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ydbio.2010.07.004","article-title":"Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size","volume":"345","author":"Wegman","year":"2010","journal-title":"Dev Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1056\/NEJM199504133321507","article-title":"Paclitaxel (taxol)","volume":"332","author":"Rowinsky","year":"1995","journal-title":"N Engl J Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/annonc\/mdp260","article-title":"Phase II study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis","volume":"21","author":"Ishigami","year":"2010","journal-title":"Ann Oncol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"10435","DOI":"10.1016\/S0021-9258(19)68639-4","article-title":"Taxol-induced polymerization of purified tubulin. Mechanism of action","volume":"256","author":"Kumar","year":"1981","journal-title":"J Biol Chem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/375424a0","article-title":"Structure of tubulin at 65 A and location of the taxol-binding site","volume":"375","author":"Nogales","year":"1995","journal-title":"Nature."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1073\/pnas.77.3.1561","article-title":"Taxol stabilizes microtubules in mouse fibroblast cells","volume":"77","author":"Schiff","year":"1980","journal-title":"Proc Natl Acad Sci USA."},{"key":"B133","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s10549-010-1278-0","article-title":"Association between patient reported outcomes and quantitative sensory tests for measuring long-term neurotoxicity in breast cancer survivors treated with adjuvant paclitaxel chemotherapy","volume":"125","author":"Hershman","year":"2011","journal-title":"Breast Cancer Res Treat."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1523\/JNEUROSCI.4464-09.2010","article-title":"Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in drosophila","volume":"30","author":"Mecklenburg","year":"2010","journal-title":"J Neurosci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"11337","DOI":"10.1523\/JNEUROSCI.2709-10.2010","article-title":"Dependence on a retinophilin\/myosin complex for stability of PKC and INAD and termination of phototransduction","volume":"30","author":"Venkatachalam","year":"2010","journal-title":"J Neurosci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.cell.2008.08.033","article-title":"Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis","volume":"135","author":"Cuttell","year":"2008","journal-title":"Cell."},{"key":"B137","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1007\/s00018-019-03203-4","article-title":"Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond","volume":"76","author":"Bayne","year":"2019","journal-title":"Cell Mol Life Sci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.tins.2014.03.004","article-title":"Parkin and PINK1: much more than mitophagy","volume":"37","author":"Scarffe","year":"2014","journal-title":"Trends Neurosci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3389\/fncel.2017.00338","article-title":"Mechanisms of cisplatin-induced ototoxicity and otoprotection","volume":"11","author":"Sheth","year":"2017","journal-title":"Front Cell Neurosci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.nbd.2010.11.017","article-title":"Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons","volume":"41","author":"Podratz","year":"2011","journal-title":"Neurobiol Dis."},{"key":"B141","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jns.2015.12.038","article-title":"Neurotoxicity to DRG neurons varies between rodent strains treated with cisplatin and bortezomib","volume":"362","author":"Podratz","year":"2016","journal-title":"J Neurol Sci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e0186250","DOI":"10.1371\/journal.pone.0186250","article-title":"Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: phenotypic and genotypic insights","volume":"12","author":"Marmiroli","year":"2017","journal-title":"PLoS ONE."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S1470-2045(10)70206-0","article-title":"Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65\/GMMG-HD4 trial","volume":"11","author":"Broyl","year":"2010","journal-title":"Lancet Oncol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1182\/blood-2010-02-268862","article-title":"Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma","volume":"116","author":"Richardson","year":"2010","journal-title":"Blood."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1177\/1535370217712690","article-title":"Next generation human skin constructs as advanced tools for drug development","volume":"242","author":"Abaci","year":"2017","journal-title":"Exp Biol Med (Maywood)."},{"key":"B146","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.neuron.2018.10.019","article-title":"Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings","volume":"100","author":"Moehring","year":"2018","journal-title":"Neuron."},{"key":"B147","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/exd.13411","article-title":"What about physical contacts between epidermal keratinocytes and sensory neurons?","volume":"27","author":"Talagas","year":"2018","journal-title":"Exp Dermatol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"e42633","DOI":"10.7554\/eLife.42633","article-title":"Cellular basis of mechanosensory Merkel-cell innervation during development","volume":"8","author":"Jenkins","year":"2019","journal-title":"Elife."},{"key":"B149","doi-asserted-by":"publisher","first-page":"180257","DOI":"10.1098.\/rsob.180257","article-title":"Beyond being innervated: the epidermis actively shapes sensory dendritic patterning","volume":"9","author":"Yang","year":"2019","journal-title":"Open Biol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38883","article-title":"Hair follicle epidermal stem cells define a niche for tactile sensation","author":"Cheng","year":"2018","journal-title":"eLife"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1126\/science.7008197","article-title":"Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness","volume":"211","author":"Bell","year":"1981","journal-title":"Science (New York, NY)."},{"key":"B152","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1089\/wound.2020.1163","article-title":"Quantitative evaluation of human umbilical vein and induced pluripotent stem cell-derived endothelial cells as an alternative cell source to skin-specific endothelial cells in engineered skin grafts","volume":"10","author":"Pappalardo","year":"2021","journal-title":"Adv Wound Care."},{"key":"B153","doi-asserted-by":"publisher","first-page":"221ra","DOI":"10.1126\/scitranslmed.3006894","article-title":"Bioengineering dermo-epidermal skin grafts with blood and lymphatic capillaries","volume":"6","author":"Marino","year":"2014","journal-title":"Sci Transl Med"},{"key":"B154","doi-asserted-by":"publisher","first-page":"e0136713","DOI":"10.1371\/journal.pone.0136713","article-title":"Melanin transfer in human 3D skin equivalents generated exclusively from induced pluripotent stem cells","volume":"10","author":"Gledhill","year":"2015","journal-title":"PLoS ONE."},{"key":"B155","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.actbio.2021.07.033","article-title":"Bio-engineering a prevascularized human tri-layered skin substitute containing a hypodermis","volume":"134","author":"Zimoch","year":"2021","journal-title":"Acta Biomater."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.drudis.2016.05.008","article-title":"Immune-competent human skin disease models","volume":"21","author":"Bergers","year":"2016","journal-title":"Drug Discov Today."},{"key":"B157","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.1038\/s41467-018-07579-y","article-title":"Tissue engineering of human hair follicles using a biomimetic developmental approach","volume":"9","author":"Abaci","year":"2018","journal-title":"Nat Commun."},{"key":"B158","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1016\/j.biomaterials.2010.03.060","article-title":"In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials."},{"key":"B159","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41586-020-2352-3","article-title":"Hair-bearing human skin generated entirely from pluripotent stem cells","volume":"582","author":"Lee","year":"2020","journal-title":"Nature."},{"key":"B160","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1600-0625.2011.01421.x","article-title":"Effects of the re-innervation of organotypic skin explants on the epidermis","volume":"21","author":"Lebonvallet","year":"2012","journal-title":"Exp Dermatol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1089\/ten.tec.2020.0296","article-title":"Skin-nerve co-culture systems for disease modeling and drug discovery","volume":"27","author":"Schutte","year":"2021","journal-title":"Tissue Eng Part C Methods."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/jid.2012.464","article-title":"Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model","volume":"133","author":"Roggenkamp","year":"2013","journal-title":"J Invest Dermatol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/exd.13118","article-title":"Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells","volume":"26","author":"Reichert","year":"2017","journal-title":"Exp Dermatol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/jid.2012.44","article-title":"Atopic keratinocytes induce increased neurite outgrowth in a coculture model of porcine dorsal root ganglia neurons and human skin cells","volume":"132","author":"Roggenkamp","year":"2012","journal-title":"J Invest Dermatol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.biomaterials.2016.10.051","article-title":"In vitro activation of the neuro-transduction mechanism in sensitive organotypic human skin model","volume":"113","author":"Martorina","year":"2017","journal-title":"Biomaterials."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.02-1180fje","article-title":"In vitro development of a tissue-engineered model of peripheral nerve regeneration to study neurite growth","volume":"17","author":"Gingras","year":"2003","journal-title":"FASEB J."},{"key":"B167","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1038\/jid.2009.159","article-title":"Improvement of nerve regeneration in tissue-engineered skin enriched with schwann cells","volume":"129","author":"Blais","year":"2009","journal-title":"J Investig Dermatol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.biomaterials.2015.01.066","article-title":"In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules","volume":"51","author":"Cadau","year":"2015","journal-title":"Biomaterials."},{"key":"B169","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1089\/ten.tea.2013.0535","article-title":"Sensory neurons accelerate skin reepithelialization via substance P in an innervated tissue-engineered wound healing model","volume":"20","author":"Blais","year":"2014","journal-title":"Tissue Eng Part A."},{"key":"B170","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.actbio.2018.10.011","article-title":"Development of an innervated tissue-engineered skin with human sensory neurons and schwann cells differentiated from iPS cells","volume":"82","author":"Muller","year":"2018","journal-title":"Acta Biomater."},{"key":"B171","doi-asserted-by":"publisher","first-page":"e10247","DOI":"10.1002\/btm2.10247","article-title":"Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells","volume":"7","author":"Guo","year":"2022","journal-title":"Bioeng Transl Med."},{"key":"B172","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.biomaterials.2018.04.044","article-title":"3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components","volume":"198","author":"Vidal","year":"2019","journal-title":"Biomaterials."}],"container-title":["Frontiers in Pain Research"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2022.912977\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T04:54:34Z","timestamp":1657256074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2022.912977\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":172,"alternative-id":["10.3389\/fpain.2022.912977"],"URL":"https:\/\/doi.org\/10.3389\/fpain.2022.912977","relation":{},"ISSN":["2673-561X"],"issn-type":[{"value":"2673-561X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"article-number":"912977"}}