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Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries and venules impacts the health of surrounding tissue and produces pathology that can both initiate pain and influence pain sensitivity. This mini review will discuss evidence for a critical role of microvascular dysfunction or injury in pathologies that contribute to chronic pain conditions such as complex regional pain syndrome (CRPS) and fibromyalgia.<\/jats:p>","DOI":"10.3389\/fpain.2023.1111559","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:10:41Z","timestamp":1675303841000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Contribution of microvascular dysfunction to chronic pain"],"prefix":"10.3389","volume":"4","author":[{"given":"Terence J.","family":"Coderre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"113272","DOI":"10.1016\/j.expneurol.2020.113272","article-title":"Biology of the human blood-nerve barrier in health and disease","volume":"328","author":"Ubogu","year":"2020","journal-title":"Exp Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"a016345","DOI":"10.1101\/cshperspect.a016345","article-title":"Inflammation and the blood microvascular system","volume":"7","author":"Pober","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.4199\/C00013ED1V01Y201006ISP008","volume-title":"Inflammation and the microcirculation","author":"Granger","year":"2010"},{"key":"B4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pain.2006.09.008","article-title":"The incidence of complex regional pain syndrome: a population-based study","volume":"129","author":"de Mos","year":"2007","journal-title":"Pain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/archneur.1987.00520170081028","article-title":"Reflex sympathetic dystrophy. 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