{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:07:06Z","timestamp":1787929626891,"version":"build-2784847793"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare health-related quality of life (HRQOL) and pelvic pain levels over time in patients with interstitial cystitis\/bladder pain syndrome (IC\/BPS) and those with other pelvic pain conditions (OPPC) including chronic prostatitis, dyspareunia, vaginismus, vulvodynia, and vulvar vestibulitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled male and female patients from any Veterans Health Administration (VHA) center in the US. They completed the Genitourinary Pain Index (GUPI) quantifying urologic HRQOL and the 12-Item Short Form Survey version 2 (SF-12) quantifying general HRQOL at enrollment and 1 year later. Participants were classified by ICD diagnosis codes and confirmed by chart review to be IC\/BPS or OPPC (308 and 85 patients respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline and follow-up, IC\/BPS patients, on average, had worse urologic and general HRQOL than OPPC patients. IC\/BPS patients demonstrated improvement in urologic HRQOL measures over the study but demonstrated no significant change in any general HRQOL measure suggesting a condition-specific impact. Patients with OPPC demonstrated similar improvements in urologic HRQOL but had deteriorating mental health and general HRQOL at follow-up suggesting a wider general HRQOL impact for these diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that patients with IC\/BPS had worse urologic HRQOL compared to other pelvic conditions. Despite this, IC\/BPS showed stable general HRQOL over time, suggesting a more condition-specific impact on HRQOL. OPPC patients showed deteriorating general HRQOL, suggesting more widespread pain symptoms in these conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpain.2023.1149783","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T04:22:54Z","timestamp":1684988574000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Quality-of-life impact of interstitial cystitis and other pelvic pain syndromes"],"prefix":"10.3389","volume":"4","author":[{"given":"Andrew R.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Dubinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"De Hoedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil E.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Freedland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Anger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/nau.20687","article-title":"Status of international consensus on interstitial cystitis\/bladder pain syndrome\/painful bladder syndrome: 2008 snapshot","volume":"28","author":"Hanno","year":"2009","journal-title":"Neurourol Urodyn"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.juro.2015.01.086","article-title":"Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome: AUA guideline amendment","volume":"193","author":"Hanno","year":"2015","journal-title":"J Urol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.juro.2006.11.084","article-title":"Prevalence of painful bladder symptoms and effect on quality of life in black, hispanic and white men and women","volume":"177","author":"Clemens","year":"2007","journal-title":"J Urol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1097\/JU.0000000000001080","article-title":"Correlates of 1-year change in quality of life in patients with urologic chronic pelvic pain syndrome: findings from the multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network","volume":"204","author":"Clemens","year":"2020","journal-title":"J Urol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0022-5347(05)65195-6","article-title":"Depressive symptoms and quality of life in patients with interstitial cystitis","volume":"167","author":"Rothrock","year":"2002","journal-title":"J Urol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.urology.2009.06.078","article-title":"Validation of a modified national institutes of health chronic prostatitis symptom index to assess genitourinary pain in both men and women","volume":"74","author":"Clemens","year":"2009","journal-title":"Urology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med Care"},{"key":"B8","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1742-1241.2009.02034.x","article-title":"High levels of anxiety and depression have a negative effect on quality of life of women with chronic pelvic pain","volume":"63","author":"Rom\u00e3o","year":"2009","journal-title":"Int J Clin Pract"},{"key":"B9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1590\/1414-431X20143710","article-title":"Prevalence and conditions associated with chronic pelvic pain in women from sao luis, Brazil","volume":"47","author":"Coelho","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"749-","DOI":"10.1136\/bmj.38748.697465.55","article-title":"Factors predisposing women to chronic pelvic pain: systematic review","volume":"332","author":"Latthe","year":"2006","journal-title":"BMJ. 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