{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:38:37Z","timestamp":1788377917861,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After REB approval, trial registration and informed consent, 92 participants were randomized to receive CH (<jats:italic>n<\/jats:italic>\u2009=\u200945) or TAU (<jats:italic>n<\/jats:italic>\u2009=\u200947). CH participants received a CH session before surgery and during post-surgical in-hospital stay HRV was assessed during rest (5\u2005min) and relaxation (10\u2005min) before and 1-month after surgery. Pain intensity was obtained using a 0\u201310 numeric rating scale pre and post 1-week and 1-month post surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One month after surgery, HRV was significantly higher in CH group (<jats:italic>n<\/jats:italic>\u2009=\u200929) during rest and relaxation (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05, <jats:italic>d<\/jats:italic>\u2009=\u20090.73) than TAU group (<jats:italic>n<\/jats:italic>\u2009=\u200928). By contrast, rest and relaxation HRV decreased from pre- to 1-month post-surgery for the TAU (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009&amp;gt;\u20090.48) but not the CH group. Pain intensity increased from pre-surgery to 1-week post-surgery (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001, <jats:italic>d<\/jats:italic>\u2009=\u20090.50), and decreased from 1-week to 1-month post-surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.005, <jats:italic>d<\/jats:italic>\u2009=\u20090.21) for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results suggest that hypnosis prevents the deleterious effects of surgery on HRV by preserving pre-operative vagal activity. These findings underscore the potential of clinical hypnosis in mitigating the adverse effects of surgery on autonomic function and may have significant implications for enhancing post-surgical recovery and pain management strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>, identifier (NCT03730350).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpain.2024.1354015","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T04:33:16Z","timestamp":1709872396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of perioperative clinical hypnosis on heart rate variability in patients undergoing oncologic surgery: secondary outcomes of a randomized controlled trial"],"prefix":"10.3389","volume":"5","author":[{"given":"Muhammad Abid","family":"Azam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliza Z.","family":"Weinrib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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