{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:58:32Z","timestamp":1793642312449,"version":"4.5.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Relieving phantom limb pain (PLP) after amputation in patients resistant to conventional therapy remains a challenge. While the causes for PLP are unclear, one model suggests that maladaptive plasticity related to cortical remapping following amputation leads to altered mental body representations (MBR) and contributes to PLP. Cognitive Multisensory Rehabilitation (CMR) has led to reduced pain in other neurologic conditions by restoring MBR. This is the first study using CMR to relieve PLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 26-year-old woman experienced excruciating PLP after amputation of the third proximal part of the leg, performed after several unsuccessful treatments (i.e., epidural stimulator, surgeries, analgesics) for debilitating neuropathic pain in the left foot for six years with foot deformities resulting from herniated discs. The PLP was resistant to pain medication and mirror therapy. PLP rendered donning a prosthesis impossible. The patient received 35 CMR sessions (2\u00d7\/day during weekdays, October\u2013December 2012). CMR provides multisensory discrimination exercises on the healthy side and multisensory motor imagery exercises of present and past actions in both limbs to restore MBR and reduce PLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After CMR, PLP reduced from 6.5\u20139.5\/10 to 0\/10 for neuropathic pain with only 4\u20135.5\/10 for muscular pain after exercising on the Numeric Pain Rating Scale. McGill Pain Questionnaire scores reduced from 39\/78 to 5\/78, and Identity (ID)-Pain scores reduced from 5\/5 to 0\/5. Her pain medication was reduced by at least 50% after discharge. At 10-month follow-up (9\/2013), she no longer took Methadone or Fentanyl. After discharge, receiving CMR as outpatient, she learned to walk with a prosthesis, and gradually did not need crutches anymore to walk independently indoors and outdoors (9\/2013). At present (3\/2024), she no longer takes pain medication and walks independently with the prosthesis without assistive devices. PLP is under control. She addresses flare-ups with CMR exercises on her own, using multisensory motor imagery, bringing the pain down within 10\u201315\u2005min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The case study seems to support the hypothesis that CMR restores MBR which may lead to long-term (12-year) PLP reduction. MBR restoration may be linked to restoring accurate multisensory motor imagery of the remaining and amputated limb regarding present and past actions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpain.2024.1374141","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T04:29:20Z","timestamp":1714019360000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Phantom limb pain relief after cognitive multisensory rehabilitation"],"prefix":"10.3389","volume":"5","author":[{"given":"Marina","family":"Zernitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Rizzello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rigoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van de Winckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"B1","first-page":"1","volume-title":"Essentials of Pain Medicine","author":"Benzon","year":"2005"},{"key":"B2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.14744\/agri.2020.83798","article-title":"The effect of postamputation pain and phantom sensations on prosthesis use, body image, and quality of life in patients with lower-extremity amputation","volume":"33","author":"Ayd\u0131n","year":"2021","journal-title":"Agri"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.12688\/f1000research.19355.1","article-title":"Recent advances in understanding and managing phantom limb pain","volume":"8","author":"Aternali","year":"2019","journal-title":"F1000Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e888","DOI":"10.1097\/PR9.0000000000000888","article-title":"Clinical updates on phantom limb pain","volume":"6","author":"Erlenwein","year":"2021","journal-title":"Pain Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S1474-4422(02)00074-1","article-title":"Phantom-limb pain: characteristics, causes, and treatment","volume":"1","author":"Flor","year":"2002","journal-title":"Lancet Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"537493","DOI":"10.3389\/fpsyg.2021.537493","article-title":"Psychological consequences in patients with amputation of a limb. 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