{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:21Z","timestamp":1753891821787,"version":"3.41.2"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aims to investigate the interregional functional connectivity in chronic back pain patients with widespread hyperalgesia, patients with localized back pain, and pain-free controls using stimulus-evoked high-density EEG recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted high-density EEG recordings to compare the functional connectivity and betweenness centrality between these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, chronic pain patients showed altered functional connectivity between regions that process cognitive information and regions that process sensory or affective information. Widespread hyperalgesia, however, is further differentiated from localized pain by decreased inter-hemispheric connectivity of sensory and affective areas and increased intra-hemispheric connectivity between sensory and cognitive cortices. Graph-theoretic analysis showed that whereas chronic pain is associated with decreased centrality of prefrontal, orbitofrontal, and cingulate areas, widespread hyperalgesia is distinguished by increased centrality of prefrontal and insular areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Together, our results show that although widespread hyperalgesia shares certain features with localized pain, it is further characterized by distinct cortical mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpain.2025.1548500","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T14:19:08Z","timestamp":1750429148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain"],"prefix":"10.3389","volume":"6","author":[{"given":"George","family":"Kenefati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika M.","family":"Rockholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Eisert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Ok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Gharibo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Daiana","family":"Voiculescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa V.","family":"Doan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe Sage","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/acr.23994","article-title":"Association of pain centralization and patient-reported pain in active rheumatoid arthritis","volume":"72","author":"Heisler","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/acr.23266","article-title":"Association between pain sensitization and disease activity in patients with rheumatoid arthritis: a cross-sectional study","volume":"70","author":"Lee","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/AJP.0000000000000619","article-title":"Association between the 2011 fibromyalgia survey criteria and multisite pain sensitivity in knee osteoarthritis","volume":"34","author":"Neville","year":"2018","journal-title":"Clin J Pain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/acr.20373","article-title":"Pain sensitivity and pain reactivity in osteoarthritis","volume":"63","author":"Lee","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1016\/S2665-9913(21)00032-1","article-title":"Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine","volume":"3","author":"Nijs","year":"2021","journal-title":"Lancet Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1002\/acr.25104","article-title":"Identifying and managing nociplastic pain in individuals with rheumatic diseases: a narrative review","volume":"75","author":"Murphy","year":"2023","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"B9","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/papr.12302","article-title":"The comparative burden of chronic widespread pain and fibromyalgia in the United States","volume":"16","author":"Schaefer","year":"2016","journal-title":"Pain Pract"},{"key":"B10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/art.34646","article-title":"Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization","volume":"65","author":"Finan","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B11","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1186\/ar3353","article-title":"Pain persists in DAS28 rheumatoid arthritis remission but not in ACR\/EULAR remission: a longitudinal observational study","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e25302","DOI":"10.7554\/eLife.25302","article-title":"Chronic pain induces generalized enhancement of aversion","volume":"6","author":"Zhang","year":"2017","journal-title":"eLife"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.cub.2020.02.091","article-title":"Mapping cortical integration of sensory and affective pain pathways","volume":"30","author":"Singh","year":"2020","journal-title":"Curr Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.celrep.2018.03.139","article-title":"Scaling up cortical control inhibits pain","volume":"23","author":"Dale","year":"2018","journal-title":"Cell Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"109978","DOI":"10.1016\/j.celrep.2021.109978","article-title":"Disrupted population coding in the prefrontal cortex underlies pain aversion","volume":"37","author":"Li","year":"2021","journal-title":"Cell Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"016050","DOI":"10.1088\/1741-2552\/ab6cba","article-title":"Granger causality analysis of rat cortical functional connectivity in pain","volume":"17","author":"Guo","year":"2020","journal-title":"J Neural Eng"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1278183","DOI":"10.3389\/fnins.2023.1278183","article-title":"Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients","volume":"17","author":"Kenefati","year":"2023","journal-title":"Front Neurosci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"108964","DOI":"10.1016\/j.jneumeth.2020.108964","article-title":"Detecting acute pain signals from human EEG","volume":"347","author":"Sun","year":"2021","journal-title":"J Neurosci Methods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s41593-023-01291-x","article-title":"Prefrontal engrams of long-term fear memory perpetuate pain perception","volume":"26","author":"Stegemann","year":"2023","journal-title":"Nat Neurosci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/s41467-019-08873-z","article-title":"Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception","volume":"10","author":"Tan","year":"2019","journal-title":"Nat Commun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1038\/nn.4645","article-title":"A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity","volume":"20","author":"Tan","year":"2017","journal-title":"Nat Neurosci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13041-023-01052-8","article-title":"Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain","volume":"16","author":"Alonso-Matielo","year":"2023","journal-title":"Mol Brain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.celrep.2015.07.001","article-title":"Role of prelimbic GABAergic circuits in sensory and emotional aspects of neuropathic pain","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Rep"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1097\/j.pain.0000000000001666","article-title":"Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography","volume":"160","author":"Ta Dinh","year":"2019","journal-title":"Pain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/hbm.24373","article-title":"Prefrontal gamma oscillations reflect ongoing pain intensity in chronic back pain patients","volume":"40","author":"May","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"B26","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.277.5328.968","article-title":"Pain affect encoded in human anterior cingulate but not somatosensory cortex","volume":"277","author":"Rainville","year":"1997","journal-title":"Science"},{"key":"B27","first-page":"353","article-title":"The role of rostral cingulumotomy in \u201cpain\u201d relief","volume":"6","author":"Foltz","year":"1968","journal-title":"Int J Neurol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3109\/08990229509101503","article-title":"Evaluation of pain perception after anterior capsulotomy: a case report","volume":"12","author":"Talbot","year":"1995","journal-title":"Somatosens Mot Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0304-3940(00)00894-6","article-title":"During pain-avoidance neurons activated in the macaque anterior cingulate and caudate","volume":"283","author":"Koyama","year":"2000","journal-title":"Neurosci Lett"},{"key":"B30","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0168-0102(01)00197-3","article-title":"Anterior cingulate activity during pain-avoidance and reward tasks in monkeys","volume":"39","author":"Koyama","year":"2001","journal-title":"Neurosci Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.pain.2011.03.002","article-title":"Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy","volume":"152","author":"Qu","year":"2011","journal-title":"Pain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.1073\/pnas.141218998","article-title":"The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex","volume":"98","author":"Johansen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B33","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.expneurol.2005.05.008","article-title":"Selective regulation of pain affect following activation of the opioid anterior cingulate cortex system","volume":"197","author":"LaGraize","year":"2006","journal-title":"Exp Neurol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1037\/h0041014","article-title":"Effect of medial cortical lesions on the avoidance behavior of the cat","volume":"58","author":"Lubar","year":"1964","journal-title":"J Comp Physiol Psychol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nn.3969","article-title":"The dorsal posterior insula subserves a fundamental role in human pain","volume":"18","author":"Segerdahl","year":"2015","journal-title":"Nat Neurosci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.2003220","article-title":"Multiple representations of pain in human cerebral cortex","volume":"251","author":"Talbot","year":"1991","journal-title":"Science"},{"key":"B37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fncel.2017.00146","article-title":"Corticostriatal regulation of acute pain","volume":"11","author":"Martinez","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1523\/JNEUROSCI.3494-14.2015","article-title":"Activation of corticostriatal circuitry relieves chronic neuropathic pain","volume":"35","author":"Lee","year":"2015","journal-title":"J Neurosci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms8660","article-title":"Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety","volume":"6","author":"Wang","year":"2015","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1523\/JNEUROSCI.2731-17.2018","article-title":"Altered excitability and local connectivity of mPFC-PAG neurons in a mouse model of neuropathic pain","volume":"38","author":"Cheriyan","year":"2018","journal-title":"J Neurosci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"107729","DOI":"10.1016\/j.celrep.2020.107729","article-title":"Sex-specific disruption of distinct mPFC inhibitory neurons in spared-nerve injury model of neuropathic pain","volume":"31","author":"Jones","year":"2020","journal-title":"Cell Rep"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/s41551-021-00736-7","article-title":"A prototype closed-loop brain-machine interface for the study and treatment of pain","volume":"10","author":"Zhang","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"B43","doi-asserted-by":"publisher","first-page":"eabm5868","DOI":"10.1126\/scitranslmed.abm5868","article-title":"Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents","volume":"14","author":"Sun","year":"2022","journal-title":"Sci Transl Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0006-8993(85)90093-9","article-title":"Analgesia elicited by prefrontal stimulation","volume":"339","author":"Hardy","year":"1985","journal-title":"Brain Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41593-023-01338-z","article-title":"First-in-human prediction of chronic pain state using intracranial neural biomarkers","volume":"26","author":"Shirvalkar","year":"2023","journal-title":"Nat Neurosci"},{"key":"B46","first-page":"958","article-title":"Bilateral cingulumotomy combined with thalamotomy or mesencephalic tractotomy for pain","volume":"134","author":"Turnbull","year":"1972","journal-title":"Surg Gynecol Obstet"},{"key":"B47","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/384258a0","article-title":"Functional imaging of an illusion of pain","volume":"384","author":"Craig","year":"1996","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1038\/s41467-018-06295-x","article-title":"Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex","volume":"9","author":"Zhou","year":"2018","journal-title":"Nat Commun"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1002\/art.40451","article-title":"Neurobiologic features of fibromyalgia are also present among rheumatoid arthritis patients","volume":"70","author":"Basu","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1002\/art.27497","article-title":"Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity","volume":"62","author":"Napadow","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1002\/art.34412","article-title":"Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia","volume":"64","author":"Napadow","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J Neurosci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1007\/s00429-015-1161-1","article-title":"Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms","volume":"221","author":"Hemington","year":"2016","journal-title":"Brain Struct Funct"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1126\/science.1067176","article-title":"Placebo and opioid analgesia- imaging a shared neuronal network","volume":"295","author":"Petrovic","year":"2002","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrn1747","article-title":"The human orbitofrontal cortex: linking reward to hedonic experience","volume":"6","author":"Kringelbach","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1186418","DOI":"10.3389\/fnins.2023.1186418","article-title":"In search of a composite biomarker for chronic pain by way of EEG and machine learning: where do we currently stand?","volume":"17","author":"Rockholt","year":"2023","journal-title":"Front Neurosci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jmpt.2014.07.006","article-title":"National institutes of health task force on research standards for chronic low back p, report of the national institutes of health task force on research standards for chronic low back pain","volume":"37","author":"Deyo","year":"2014","journal-title":"J Manipulative Physiol Ther"},{"key":"B58","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fnins.2013.00267","article-title":"MEG and EEG data analysis with MNE-python","volume":"7","author":"Gramfort","year":"2013","journal-title":"Front Neurosci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fninf.2015.00016","article-title":"The PREP pipeline: standardized preprocessing for large-scale EEG analysis","volume":"9","author":"Bigdely-Shamlo","year":"2015","journal-title":"Front Neuroinform"},{"key":"B60","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1109\/72.761722","article-title":"Fast and robust fixed-point algorithms for independent component analysis","volume":"10","author":"Hyvarinen","year":"1999","journal-title":"IEEE Trans Neural Netw"},{"key":"B61","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuroimage.2017.06.030","article-title":"Autoreject: automated artifact rejection for MEG and EEG data","volume":"159","author":"Jas","year":"2017","journal-title":"Neuroimage"},{"key":"B62","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0896-6273(00)81138-1","article-title":"Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity","volume":"26","author":"Dale","year":"2000","journal-title":"Neuron"},{"key":"B63","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/(SICI)1097-0193(1999)8:4%3C272::AID-HBM10%3E3.0.CO;2-4","article-title":"High-resolution intersubject averaging and a coordinate system for the cortical surface","volume":"8","author":"Fischl","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"B64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb Cortex"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2010.06.010","article-title":"Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature","volume":"53","author":"Destrieux","year":"2010","journal-title":"Neuroimage"},{"key":"B66","doi-asserted-by":"publisher","first-page":"117051","DOI":"10.1016\/j.neuroimage.2020.117051","article-title":"Phase- and amplitude-coupling are tied by an intrinsic spatial organization but show divergent stimulus-related changes","volume":"219","author":"Mostame","year":"2020","journal-title":"Neuroimage"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.neuroimage.2011.01.055","article-title":"An improved index of phase-synchronization for electrophysiological data in the presence of volume-conduction, noise and sample-size bias","volume":"55","author":"Vinck","year":"2011","journal-title":"Neuroimage"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/hbm.20346","article-title":"Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources","volume":"28","author":"Stam","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1126\/science.1099745","article-title":"Neuronal oscillations in cortical networks","volume":"304","author":"Buzsaki","year":"2004","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1002\/hbm.20705","article-title":"Two systems of resting state connectivity between the insula and cingulate cortex","volume":"30","author":"Taylor","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"B72","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pain.2012.07.029","article-title":"Default mode network connectivity encodes clinical pain: an arterial spin labeling study","volume":"154","author":"Loggia","year":"2013","journal-title":"Pain"},{"key":"B73","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.tins.2014.11.006","article-title":"The dynamic pain connectome","volume":"38","author":"Kucyi","year":"2015","journal-title":"Trends Neurosci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/j.pain.0000000000001087","article-title":"Electroencephalography and magnetoencephalography in pain research-current state and future perspectives","volume":"159","author":"Ploner","year":"2018","journal-title":"Pain"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e997","DOI":"10.1097\/j.pain.0000000000002565","article-title":"Longitudinal resting-state electroencephalography in patients with chronic pain undergoing interdisciplinary multimodal pain therapy","volume":"163","author":"Heitmann","year":"2022","journal-title":"Pain"},{"key":"B76","doi-asserted-by":"publisher","first-page":"102241","DOI":"10.1016\/j.nicl.2020.102241","article-title":"Abnormal alpha band power in the dynamic pain connectome is a marker of chronic pain with a neuropathic component","volume":"26","author":"Kisler","year":"2020","journal-title":"Neuroimage Clin"},{"key":"B77","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1523\/JNEUROSCI.5877-11.2012","article-title":"Gamma-band oscillations in the primary somatosensory cortex\u2013a direct and obligatory correlate of subjective pain intensity","volume":"32","author":"Zhang","year":"2012","journal-title":"J Neurosci"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1371\/journal.pbio.0050133","article-title":"Gamma oscillations in human primary somatosensory cortex reflect pain perception","volume":"5","author":"Gross","year":"2007","journal-title":"PLoS Biol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"552650","DOI":"10.3389\/fnins.2020.552650","article-title":"Hyperalgesia and central sensitization in subjects with chronic orofacial pain: analysis of pain thresholds and EEG biomarkers","volume":"14","author":"Baroni","year":"2020","journal-title":"Front Neurosci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3389\/fnins.2018.00750","article-title":"Elevated resting state gamma oscillatory activities in electroencephalogram of patients with post-herpetic neuralgia","volume":"12","author":"Zhou","year":"2018","journal-title":"Front Neurosci"},{"key":"B81","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s11682-011-9135-2","article-title":"Correlations between EEG and clinical outcome in chronic neuropathic pain: surgical effects and treatment resistance","volume":"5","author":"Michels","year":"2011","journal-title":"Brain Imaging Behav"},{"key":"B82","doi-asserted-by":"publisher","first-page":"fcab014","DOI":"10.1093\/braincomms\/fcab014","article-title":"Chronic pain as a brain imbalance between pain input and pain suppression","volume":"3","author":"Vanneste","year":"2021","journal-title":"Brain Commun"},{"key":"B83","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1093\/cercor\/bhv043","article-title":"Prefrontal gamma oscillations encode tonic pain in humans","volume":"25","author":"Schulz","year":"2015","journal-title":"Cereb Cortex"},{"key":"B84","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1093\/brain\/awy281","article-title":"The search for pain biomarkers in the human brain","volume":"141","author":"Mouraux","year":"2018","journal-title":"Brain"},{"key":"B85","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.neuroimage.2010.05.073","article-title":"Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres","volume":"54","author":"Gee","year":"2011","journal-title":"Neuroimage"},{"key":"B86","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pnpbp.2012.11.003","article-title":"Decreased interhemispheric resting-state functional connectivity in first-episode, drug-naive major depressive disorder","volume":"41","author":"Guo","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1002\/hbm.23097","article-title":"Major depressive disorder: findings of reduced homotopic connectivity and investigation of underlying structural mechanisms","volume":"37","author":"Hermesdorf","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"B88","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41398-019-0467-9","article-title":"Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder","volume":"9","author":"Jiang","year":"2019","journal-title":"Transl Psychiatry"},{"key":"B89","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1089\/brain.2015.0405","article-title":"Interhemispheric dorsolateral prefrontal Cortex connectivity is associated with individual differences in pain sensitivity in healthy controls","volume":"6","author":"Sevel","year":"2016","journal-title":"Brain Connect"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1002\/art.41440","article-title":"Association of dysregulated central pain processing and response to disease-modifying antirheumatic drug therapy in rheumatoid arthritis","volume":"72","author":"Heisler","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.3171\/2020.10.JNS203323","article-title":"Anterior insula stimulation increases pain threshold in humans: a pilot study","volume":"135","author":"Liu","year":"2021","journal-title":"J Neurosurg"},{"key":"B92","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuroimage.2018.11.059","article-title":"Tonic thermonociceptive stimulation selectively modulates ongoing neural oscillations in the human posterior insula: evidence from intracerebral EEG","volume":"188","author":"Liberati","year":"2019","journal-title":"Neuroimage"},{"key":"B93","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"105749","DOI":"10.1016\/j.neubiorev.2024.105749","article-title":"Sex differences in mechanisms of pain hypersensitivity","volume":"163","author":"Mogil","year":"2024","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Frontiers in Pain Research"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2025.1548500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T14:19:09Z","timestamp":1750429149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2025.1548500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":94,"alternative-id":["10.3389\/fpain.2025.1548500"],"URL":"https:\/\/doi.org\/10.3389\/fpain.2025.1548500","relation":{},"ISSN":["2673-561X"],"issn-type":[{"type":"electronic","value":"2673-561X"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"article-number":"1548500"}}