{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:07Z","timestamp":1783318507287,"version":"3.54.6"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pain is among the most prevalent and distressing symptoms in advanced cancer, impairing physical, emotional, and social well-being. Management often requires support from family caregivers, whose own health and psychological well-being may also be adversely affected. This study examined the potential utility of digital phenotyping-moment-to-moment quantification of individual-level human behavior-to assess pain and physical quality of life (QOL) in patients with advanced cancer and their family caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with advanced cancer (\n                      <jats:italic>n<\/jats:italic>\n                      = 14) and their caregivers (\n                      <jats:italic>n<\/jats:italic>\n                      = 32) installed the Beiwe smartphone application, which enabled passive GPS data collection over 24 weeks. Raw GPS data were processed into daily mobility features and aggregated using biweekly moving averages and variability measures. Participants completed PROMIS measures of pain (intensity and interference) and physical QOL every 6 weeks. Within-person regression models were used to examine associations between changes in passive mobility features and changes in outcomes, with adjusted R\u00b2 interpreted as effect size (small = 0.02, medium = 0.13, large = 0.26).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Caregiver GPS-derived mobility features predicted a large proportion of variance in patient pain intensity (R\u00b2 = 0.31) and pain interference (R\u00b2 = 0.32). Combined caregiver and patient mobility data predicted large variance in caregiver physical QOL (R\u00b2 = 0.43) and medium-to-large variance in patient pain intensity (R\u00b2 = 0.16) and pain interference (R\u00b2 = 0.33). Patient mobility features alone predicted small variance in caregiver physical QOL (R\u00b2 = 0.02). When examining patient data predicting patient outcomes, mobility features were associated with small variance in physical QOL (R\u00b2 = 0.03), pain intensity (R\u00b2 = 0.05), and pain interference (R\u00b2 = 0.08).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that digital phenotyping may be a useful approach for predicting pain and physical QOL in advanced cancer, particularly when incorporating both patient and caregiver data. Further research is warranted to evaluate digital phenotyping as a novel method for monitoring symptoms and functional outcomes in advanced cancer care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpain.2026.1767157","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:36:49Z","timestamp":1783316209000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the predictive capacity of smartphone-based digital phenotyping to monitor pain and physical quality of life in advanced cancer patients, family caregivers, and dyads"],"prefix":"10.3389","volume":"7","author":[{"given":"Kristen","family":"Allen-Watts","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine and Population Science, School of Medicine, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Azuero","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmi","family":"Lee","sequence":"additional","affiliation":[{"name":"Frances Payne Bolton School of Nursing, Case Western Reserve University","place":["Cleveland, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin R.","family":"Harrell","sequence":"additional","affiliation":[{"name":"Division of Behavioral and Social Research, National Institute on Aging, National Institutes of Health","place":["Bethesda, MD, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Currie","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery C.","family":"Bechthold","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Tennessee at Knoxville","place":["Knoxville, TN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Engler","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleigh","family":"Curry","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Puga","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natashia","family":"Bibriescas","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Alabama at Birmingham","place":["Birmingham, AL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif H.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University School of Medicine","place":["Durham, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Center for Optimal Aging and Serious Illness Research, Division of Palliative Care and Geriatric Medicine, Mass General Brigham and Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Demiris","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences, School of Nursing & Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexi A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute; 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