{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:12:12Z","timestamp":1785334332294,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016624","name":"Applied Science Private University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare the clinical and electrophysiological effects of neurodynamic techniques vs. desensitization maneuvers in women with moderate carpal tunnel syndrome (CTS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized clinical trial. The study included 380 female participants with moderate carpal tunnel syndrome, aged between 45 and 55 years, who were randomly assigned to a neurodynamic technique group or a desensitization maneuvers group. Neurodynamic techniques in one group and desensitization in the other group were conducted for 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>Measures were nerve conduction, pain, symptom severity, and functional status using the Boston Carpal Tunnel Questionnaire, and cylindrical and pincer grip strength before treatment and after 3 months of treatment. One-year follow-up for pain, symptom severity, and functional status using the Boston Carpal Tunnel Questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups demonstrated significant within-group improvements in nerve conduction, pain, symptom severity, and functional status (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Between-group analysis showed greater improvements in sensory and motor nerve conduction, pain, symptom severity, and functional status in the desensitization group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Improvements in cylindrical and pincer grip strength were significant only in the desensitization group. Clinical gains in pain and function were maintained at 1-year follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both interventions were effective in women with moderate CTS; however, desensitization maneuvers demonstrated superior improvements in neurophysiological outcomes, pain, and function over 12 weeks, with sustained benefits at 1-year follow-up.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                      <jats:ext-link>http:\/\/www.clinicaltrials.gov\/<\/jats:ext-link>\n                      , NCT05150912.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpain.2026.1792933","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:37:54Z","timestamp":1784785074000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurodynamic techniques vs. desensitization maneuvers in the manual therapy management of moderate carpal tunnel syndrome among women: randomized clinical trial with 1-year follow-up"],"prefix":"10.3389","volume":"7","author":[{"given":"Mohamed I.","family":"Mabrouk","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Abdalbary","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Physical Therapy, Faculty of Physical Therapy, Nahda University","place":["Beni Suef, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab A. A.","family":"El-Shaarawy","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Cairo University","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Elmahgoub","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Aburub","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Z.","family":"Darabseh","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, School of Rehabilitation Sciences, The University of Jordan","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Makai","sequence":"additional","affiliation":[{"name":"Institute of Physiotherapy and Sports Science, Faculty of Health Sciences, Pecsi Tudomanyegyetem Egeszsegtudomanyi Kar","place":["P\u00e9cs, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongr\u00e1c","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Institute of Physiotherapy and Sports Science, Faculty of Health Sciences, Pecsi Tudomanyegyetem Egeszsegtudomanyi Kar","place":["P\u00e9cs, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.2106\/JBJS.20.02126","article-title":"Optimizing costs and outcomes for carpal tunnel release surgery, a cost-effectiveness analysis from societal and health-care system perspectives","volume":"103","author":"Rogers","year":"2021","journal-title":"J Bone Joint Surg Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: clinical features, diagnosis, and management","volume":"15","author":"Pauda","year":"2016","journal-title":"Lancet Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"Atroshi","year":"1999","journal-title":"J Am Med Assoc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1097\/PHM.0000000000001609","article-title":"A systematic review of the efficacy of corticosteroid injections of tendon sheaths, excluding stenosing tenosynovitis of the wrist and hand","volume":"100","author":"Cushman","year":"2021","journal-title":"Am J Phys Med Rehabil"},{"key":"B5","doi-asserted-by":"publisher","first-page":"566","DOI":"10.2519\/jospt.2021.10533","article-title":"Short-term effects of neurodynamic techniques for treating carpal tunnel syndrome: a systematic review with meta-analysis","volume":"51","author":"N\u00fa\u00f1ez de Arenas-Arroyo","year":"2021","journal-title":"J Orthop Sports Phys Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jht.2016.09.002","article-title":"Is there a relationship between impaired median nerve excursion and carpal tunnel syndrome? 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