{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:46:34Z","timestamp":1782798394807,"version":"3.54.5"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Psychoemotional Factors Are Closely Associated With Health-Related Quality Of Life (Hrqol) In Individuals With Chronic Low Back Pain (Clbp). However, It Remains Unclear Whether These Associations Differ Between Women And Men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To Evaluate Sex-Stratified Associations Between Psychoemotional Factors And Hrqol Domains In Adults With Chronic Nonspecific Clbp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>This Cross-Sectional Study Included 223 Adults With Chronic Nonspecific Clbp (138 Women And 85 Men) Assessed Before Initiation Of Outpatient Rehabilitation. Pain Intensity, Anxiety, Depression, Perceived Stress, Kinesiophobia, And Hrqol Were Evaluated Using Standardized Questionnaires. Primary Analyses Examined Associations Between Psychoemotional Thresholds And Eight Sf-36 Domains Separately In Women And Men. Secondary Analyses Assessed Severe Pain (Vas \u22657). Exploratory Logistic Regression Models With Sex-By-Variableinteraction Terms Were Additionally Performed. Multiple Testing Was Controlled Using The Benjamini\u2013Hochberg False Discovery Rate Procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Prevalence Of Clinically Significant Anxiety, Depression, High Perceived Stress, And Kinesiophobia Did Not Differ Significantly Between Women And Men. In Sex-Stratified Analyses, Elevated Psychoemotional Burden In Women Was Primarily Associated With Lower Scores In Vitality, Mental Health, Social Functioning, And General Health. In Men, Associations Involved A Broader Range Of Hrqol Domains, Including Physical Functioning, Role Limitations, Bodily Pain, And General Health. In Secondary Analyses, High Kinesiophobia Was Associated With Severe Pain In Women (Or 9.00, 95% Ci 2.01\u201340.32;\n                      <jats:italic>Q<\/jats:italic>\n                      \u2009=\u20090.033), Whereas No Psychoemotional Indicator Remained Significantly Associated With Severe Pain In Men After Correction For Multiple Testing. However, Exploratory Sex-By-Variableinteraction Analyses Did Not Demonstrate Statistically Robust Interaction Effects After Adjustment For Potential Confounders And Correction For Multiple Testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychoemotional Factors Were Closely Associated With Hrqol In Adults With Chronic Nonspecific Clbp. Although Sex-Stratified Analyses Revealed Different Patterns Of Associations In Women And Men, Formal Interaction Analyses Did Not Provide Statistically Robust Evidence That These Associations Differed By Sex. The Findings Support The Importance Of Considering Psychoemotional Factors During Assessment And Rehabilitation Planning In Patients With Chronic Nonspecific Clbp And May Help Inform Future Individualized Rehabilitation Approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpain.2026.1872295","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:37:33Z","timestamp":1782797853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-related associations between psychoemotional factors and health-related quality of life in patients with chronic low back pain"],"prefix":"10.3389","volume":"7","author":[{"given":"Mariia","family":"Ovdii","sequence":"first","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola","family":"Kondratiuk","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Yaremenko","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Prokopiv","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Potapova","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Borysenko","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Lazarieva","sequence":"additional","affiliation":[{"name":"National University of Ukraine on Physical Education and Sport","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iurii","family":"Kuchyn","sequence":"additional","affiliation":[{"name":"Bogomolets National Medical University","place":["Kyiv, Ukraine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e305","DOI":"10.1016\/s2665-9913(23)00133-9","article-title":"The global epidemic of low back pain","volume":"5","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"B2","author":"Tan","year":"2025"},{"key":"B3","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3390\/bioengineering12080878","article-title":"Comprehensive analysis of chronic low back pain: morphological and functional impairments, physical activity patterns, and epidemiology in a German population-based cross-sectional study","volume":"12","author":"Hoehl","year":"2025","journal-title":"Bioengineering"},{"key":"B4","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.spinee.2021.02.006","article-title":"Corrigendum to \u201cguideline summary review: an evidence-based clinical guideline for the diagnosis and treatment of low back pain\u201d [the spine journal 20\/7 (2020) p 998\u20131024]","volume":"21","author":"Kreiner","year":"2021","journal-title":"Spine J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1001\/jama.2010.344","article-title":"Will this patient develop persistent disabling low back pain?","volume":"303","author":"Chou","year":"2010","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"20040","DOI":"10.1038\/s41598-022-24703-7","article-title":"Chronic low back pain and its impact on physical function, mental health, and health-related quality of life: a cross-sectional study in Singapore","volume":"12","author":"Ge","year":"2022","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1590\/s0034-8910.2015049005874","article-title":"Prevalence of chronic low back pain: systematic review","author":"Meucci","year":"2015","journal-title":"Revista de Sa\u00fade P\u00fablica"},{"key":"B8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11482-012-9172-z","article-title":"Quality of life in the decayed historic areas of isfahan (DHI) using the world health organization quality of life instrument (WHOQOL-BREF)","volume":"7","author":"Nooraie","year":"2012","journal-title":"Appl Res Qual Life"},{"key":"B9","doi-asserted-by":"publisher","first-page":"100413","DOI":"10.1016\/j.bjpt.2022.100413","article-title":"Which psychosocial factors are related to severe pain and functional limitation in patients with low back pain?","volume":"26","author":"Corr\u00eaa","year":"2022","journal-title":"Braz J Phys Ther"},{"key":"B10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.physio.2015.01.006","article-title":"Identifying potential moderators for response to treatment in low back pain: a systematic review","volume":"101","author":"Gurung","year":"2015","journal-title":"Physiotherapy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1097\/j.pain.0000000000000146","article-title":"How does pain lead to disability? A systematic review and meta-analysis of mediation studies in people with back and neck pain","volume":"156","author":"Lee","year":"2015","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"E133","DOI":"10.1097\/00007632-200203010-00020","article-title":"Cognitive-Behavioral therapy and psychosocial factors in low back pain","volume":"27","author":"Pincus","year":"2002","journal-title":"Spine"},{"key":"B13","author":"Keogh","year":"2024"},{"key":"B14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.32689\/2663-0672-2025-2-11","article-title":"Justification of a diagnostic algorithm for patients with chronic lower back pain","volume":"2","author":"Ovdii","year":"2025","journal-title":"Mod Med Pharmacy Psychol Health"},{"key":"B15","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/papr.12216","article-title":"Measuring the intensity of chronic pain: are the visual analogue scale and the verbal rating scale interchangeable?","volume":"15","author":"Kliger","year":"2014","journal-title":"Pain Pract"},{"key":"B16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000527041","article-title":"Chronic pain and psychiatric conditions","volume":"9","author":"Johnston","year":"2022","journal-title":"Complex Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/abm\/kaad015","article-title":"The perceived stress scale as a measure of stress: decomposing score variance in longitudinal behavioral medicine studies","volume":"57","author":"Harris","year":"2023","journal-title":"Ann Behav Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1515\/sjpain-2021-0200","article-title":"Less is more: reliability and measurement error for three versions of the Tampa scale of kinesiophobia (TSK-11, TSK-13, and TSK-17) in patients with high-impact chronic pain","volume":"23","author":"Eiger","year":"2022","journal-title":"Scand J Pain"},{"key":"B19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-ltem short-form health survey (SF-36)","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"B20","year":""},{"key":"B21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.26661\/2310-4368\/2022-2-2","article-title":"Perceived stress scale (PSS-10): adaptation and approbation in the war circumstances","volume":"2","author":"Veldbrekht","year":"2022","journal-title":"Psychology J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.32471\/rheumatology.2707-6970.95.1871","article-title":"Adaptation and validation of the Tampa scale of kinesiophobia in patients with rheumatoid arthritis","volume":"95","author":"Bombela","year":"2024","journal-title":"Ukr J Rheumatol"},{"key":"B23","first-page":"9","article-title":"The procedure of adaptation of international quality of life questionnaire MOS SF-36 in Ukraine: the experience of administration in asthma patients","volume":"3","author":"Feshchenko","year":"2002","journal-title":"Ukr Pulm J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e0216858","DOI":"10.1371\/journal.pone.0216858","article-title":"Efficacy of virtual reality to reduce chronic low back pain: proof-of-concept of a non-pharmacological approach on pain, quality of life, neuropsychological and functional outcome","volume":"14","author":"Alemanno","year":"2019","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"6149","DOI":"10.3390\/jcm13206149","article-title":"A systematic review on the neuropsychological assessment of patients with LBP: the impact of chronic pain on quality of life","volume":"13","author":"Anselmo","year":"2024","journal-title":"J Clin Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pmn.2020.11.012","article-title":"Behavioral symptom clusters, inflammation, and quality of life in chronic low back pain","volume":"22","author":"Saravanan","year":"2021","journal-title":"Pain Manag Nurs"},{"key":"B27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/21642850.2021.2022487","article-title":"Determinants of quality of life in individuals with chronic low back pain: a systematic review","volume":"10","author":"Agnus Tom","year":"2022","journal-title":"Health Psychol Behav Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1055\/s-0041-1734385","article-title":"Do patients of chronic low back pain have psychological comorbidities?","volume":"11","author":"Singhal","year":"2021","journal-title":"Avicenna J Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e40844","DOI":"10.2196\/40844","article-title":"Mhealth intervention for improving pain, quality of life, and functional disability in patients with chronic pain: systematic review","volume":"11","author":"Moreno-Ligero","year":"2023","journal-title":"JMIR Mhealth Uhealth"},{"key":"B30","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/pm\/pnaa368","article-title":"Female gender is associated with a higher prevalence of chronic neck pain, chronic low back pain, and migraine: results of the Spanish national health survey, 2017","volume":"22","author":"Palacios-Ce\u00f1a","year":"2020","journal-title":"Pain Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bjpt.2019.01.012","article-title":"Low back pain and some associated factors: is there any difference between genders?","volume":"24","author":"Bento","year":"2020","journal-title":"Braz J Phys Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1097\/j.pain.0000000000000775","article-title":"Individual differences in pain: understanding the mosaic that makes pain personal","volume":"158","author":"Fillingim","year":"2016","journal-title":"Pain"},{"key":"B33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.intimp.2015.05.020","article-title":"A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients","volume":"27","author":"White","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/jnr.23856","article-title":"Sex-based differences in brain alterations across chronic pain conditions","volume":"95","author":"Gupta","year":"2016","journal-title":"J Neurosci Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.pain.2010.08.012","article-title":"Corrigendum to \u201cgender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review (vol 150 (2010) 309\u2013318)","volume":"151","author":"Popescu","year":"2010","journal-title":"Pain"},{"key":"B36","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/jpm14050496","article-title":"Quality of life in patients with chronic low back pain and differences by sex: a longitudinal study","volume":"14","author":"Pericot-Mozo","year":"2024","journal-title":"J Pers Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00586-022-07109-x","article-title":"Validation of the work ability index\u2014single item and the pain disability index\u2014work item in patients with chronic low back pain","volume":"31","author":"Boekel","year":"2022","journal-title":"Eur Spine J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"10657","DOI":"10.3390\/ijerph191710657","article-title":"Quality of life and mental distress in patients with chronic low back pain: a cross-sectional study","volume":"19","author":"Hnate\u0161en","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.20471\/acc.2025.64.02.09","article-title":"Correlation of physical and mental components of health-related quality of life, function and pain in patients with chronic nonspecific low back pain","volume":"64","author":"Berkovi\u0107-\u0160ubi\u0107","year":"2025","journal-title":"Acta Clin Croat"},{"key":"B40","doi-asserted-by":"publisher","first-page":"32","DOI":"10.30841\/2786-7323.4.2024.322116","article-title":"Chronic low back pain and associated risk factors: are there any sex differences?","author":"Ovdii","year":"2024","journal-title":"Health of Man"},{"key":"B41","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/j.pain.0000000000003406","article-title":"Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features","volume":"166","author":"Rometsch","year":"2024","journal-title":"Pain"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/jci191931","article-title":"Sex differences in the transition to chronic pain","volume":"135","author":"Smith","year":"2025","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Pain Research"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2026.1872295\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:37:34Z","timestamp":1782797854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpain.2026.1872295\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":42,"alternative-id":["10.3389\/fpain.2026.1872295"],"URL":"https:\/\/doi.org\/10.3389\/fpain.2026.1872295","relation":{},"ISSN":["2673-561X"],"issn-type":[{"value":"2673-561X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"article-number":"1872295"}}