{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:19Z","timestamp":1787811499163,"version":"build-2784847793"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pain Res."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional \u201cself-limiting\u201d perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirteen participants with acute LBP (&amp;lt;4 weeks duration) underwent clinical, psychometric, and functional magnetic resonance imaging (fMRI) assessments. Brain activity and connectivity were mapped during lumbar mechanosensory stimulation, with a focused analysis on sensorimotor, salience, cerebellar, and limbic networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pain intensity demonstrated a negative correlation with posterior supramarginal-precuneus connectivity and a positive correlation with cerebellar activity. Fear-avoidance behavior was positively associated with connectivity across a cerebellar-limbic axis (cerebellum, brainstem, and hippocampus). Furthermore, mechanical pain summation (wind-up ratio) and movement control impairments were significantly linked to connectivity shifts within the salience and sensorimotor-lateral networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate that acute LBP is characterized by immediate widespread neuronal reorganization. The modulation of these networks by pain intensity and motor dysfunction suggests an early interplay between sensory, motor, and affective processing. Identifying these neural signatures provides a mechanistic framework for targeted biopsychosocial interventions designed to intercept the transition from acute pain to chronic disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpain.2026.1884788","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:34:39Z","timestamp":1787808879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain"],"prefix":"10.3389","volume":"7","author":[{"given":"Sabina","family":"Hotz-Boendermaker","sequence":"first","affiliation":[{"name":"School of Health Sciences, Institute of Physiotherapy, University of Applied Sciences ZHAW","place":["Winterthur, Switzerland"]},{"name":"Department of Human Physiology and Physiotherapy, Faculty of Physical Education & 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Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Michels","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital Zurich","place":["Zurich, Switzerland"]},{"name":"Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1136\/annrheumdis-2013-204428","article-title":"The global burden of low back pain: estimates from the global burden of disease 2010 study","volume":"73","author":"Hoy","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"s169","DOI":"10.1007\/s00586-006-1071-2","article-title":"chapter 3: european guidelines for the management ofacute nonspecific low back painin 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