{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:13Z","timestamp":1753892053165,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Parasitol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The INSPIRED project aims to develop inclusive Digital Optical Diagnostic Devices (DODDs) for schistosomiasis, to support disease management by enabling rapid diagnostic results, to improve efficient data management to guide decision-making and to provide healthcare workers with critical health information to facilitate follow-up action. Due to the non-availability of Target Product Profiles (TPPs) for guiding the development of digital diagnostics for schistosomiasis, we explored existing diagnostic TPPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a curated open access database (Notion database), we studied a selection of TPPs for diagnosing infectious diseases, focusing on specifications related to digital health products for Neglected Tropical Diseases (NTDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen TPPs originating from 12 documents, covering 13 specific diseases, were selected and their characteristics were labeled and entered into the database. Further exploration of the database revealed several gaps, including a lack of stakeholder input, sustainability, and TPP availability. Other significant gaps related to digital health platform interconnectivity and data stewardship specifically in relation to digital diagnostics, including DODDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings reflect two possible scenarios: (1) there is currently no need for digital diagnostic devices for schistosomiasis and, by extension for other NTDs; or (2) those needs are not yet covered by TPPs. Therefore, we recommend that digital health diagnostics are included in the use cases for schistosomiasis control and elimination, at least in the ideal\/desirable scenario, as this will guide research and incentivize investment in digital health diagnostics for schistosomiasis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpara.2023.1255848","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:40:11Z","timestamp":1695804011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Developing inclusive digital health diagnostic for schistosomiasis: a need for guidance via target product profiles"],"prefix":"10.3389","volume":"2","author":[{"given":"Adeola","family":"Onasanya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Bengtson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludo","family":"de Goeje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"van Engelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Carel","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/medsci6020039","article-title":"Tools for detection of schistosomiasis in resource limited settings","volume":"6","author":"Ajibola","year":"2018","journal-title":"Med. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.4269\/ajtmh.21-1071","article-title":"Point-of-care sample preparation and automated quantitative detection of schistosoma haematobium using mobile phone microscopy","volume":"106","author":"Armstrong","year":"2022","journal-title":"Am. J. Trop. Med. Hygiene"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26295","article-title":"An artificial intelligence-assisted diagnostic platform for rapid near-patient hematology","volume":"96","author":"Bachar","year":"2021","journal-title":"Am. J. Hematol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-006968","article-title":"How can we better integrate the prevention, treatment, control and elimination of neglected tropical diseases with other health interventions","volume":"6","author":"Banda","year":"2021","journal-title":"A systematic review. BMJ Global Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1017\/S0031182014000432","article-title":"Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection","volume":"141","author":"Bogoch","year":"2014","journal-title":"Parasitology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105150","article-title":"An innovative and user-friendly scoring system for standardised quantitative interpretation of the urine-based point-of-care strip test (POC-CCA) for the diagnosis of intestinal schistosomiasis: A proof-of-concept study","volume":"199","author":"Casacuberta-Partal","year":"2019","journal-title":"Acta Tropica"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00858","article-title":"The advances in molecular and new point-of-care (POC) diagnosis of schistosomiasis pre- and post-praziquantel use: in the pursuit of more reliable approaches for low endemic and non-endemic areas","volume":"10","author":"Cavalcanti","year":"2019","journal-title":"Front. Immunol."},{"volume-title":"What is digital health?","year":"2020","key":"B8"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0000064","DOI":"10.1371\/journal.pdig.0000064","article-title":"The potential of digital molecular diagnostics for infectious diseases in sub-Saharan Africa","volume":"1","author":"Cunnington","year":"2022","journal-title":"PloS Digit Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e248","DOI":"10.1016\/S2214-109X(17)30024-4","article-title":"Sustainable clinical laboratory capacity for health in Africa","volume":"5","author":"Davies","year":"2017","journal-title":"Lancet Global Health"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1188\/16.CJON.598-599","article-title":"The MarginProbe\u00ae system: an innovative approach to reduce the incidence of positive margins found after lumpectomy","volume":"20","author":"Gola","year":"2016","journal-title":"Clin. J. Oncol. Nursing"},{"key":"B12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/13558196221110416","article-title":"Towards sustainability for medical devices and consumables: The radical and incremental challenges in the technology ecosystem","volume":"27","author":"Hinrichs-Krapels","year":"2022","journal-title":"J. Health Serv. Res. Policy"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fitd.2021.722438","article-title":"Context-specific procedures for the diagnosis of human schistosomiasis \u2013 A mini review","volume":"2","author":"Hoekstra","year":"2021","journal-title":"Front. Trop. Dis."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2017.1337325","article-title":"Point-of-care mobile digital microscopy and deep learning for the detection of soil-transmitted helminths and Schistosoma haematobium","volume":"10","author":"Holmstr\u00f6m","year":"2017","journal-title":"Global Health Action"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182022001664","article-title":"A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis: from research and development to commercialisation","volume":"150","author":"Meulah","year":"2022","journal-title":"Parasitology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.4269\/ajtmh.22-0276","article-title":"Performance evaluation of the schistoscope 5.0 for (Semi-)automated digital detection and quantification of schistosoma haematobium eggs in urine: A field-based study in Nigeria","volume":"107","author":"Meulah","year":"2022","journal-title":"Am. J. Trop. Med. Hygiene"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e0009569","DOI":"10.1371\/journal.pntd.0009569","article-title":"Field assessment in Cameroon of a reader of POC-CCA lateral flow strips for the quantification of Schistosoma mansoni circulating cathodic antigen in urine","volume":"15","author":"Mewamba","year":"2021","journal-title":"PloS Negl. Trop. Dis."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed8030176","article-title":"Towards inclusive diagnostics for neglected tropical diseases: user experience of a new digital diagnostic device in low-income settings","volume":"8","author":"Onasanya","year":"2023","journal-title":"Trop. Med. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.564381","article-title":"A stakeholder analysis of schistosomiasis diagnostic landscape in South-West Nigeria: insights for diagnostics co-creation","volume":"8","author":"Onasanya","year":"2020","journal-title":"Front. Public Health"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/mi13050643","article-title":"Schistoscope: an automated microscope with artificial intelligence for detection of schistosoma haematobium eggs in resource-limited settings","volume":"13","author":"Oyibo","year":"2022","journal-title":"Micromachines"},{"key":"B21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1086\/499363","article-title":"Laboratory medicine in africa: A barrier to effective health care","volume":"42","author":"Petti","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.apergo.2016.08.034","article-title":"Human factors in the design of medical devices\u2014Approaches to meeting international standards in the European Union and USA","volume":"59","author":"Privitera","year":"2017","journal-title":"Appl. Ergonomics"},{"key":"B23","article-title":"Digital health","volume-title":"StatPearls","author":"Ronquillo","year":"2022"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004347","article-title":"Low-cost transcriptional diagnostic to accurately categorize lymphomas in low- and middle-income countries","volume":"5","author":"Valvert","year":"2021","journal-title":"Blood Advances"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0216277","DOI":"10.1371\/journal.pone.0216277","article-title":"Performance of non-laboratory staff for diagnostic testing and specimen collection in HIV programs: A systematic review and meta-analysis","volume":"14","author":"Vojnov","year":"2019","journal-title":"PloS One"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010500","article-title":"Affordable artificial intelligence-based digital pathology for neglected tropical diseases: A proof-of-concept for the detection of soil-transmitted helminths and Schistosoma mansoni eggs in Kato-Katz stool thick smears","volume":"16","author":"Ward","year":"2022","journal-title":"PloS Negl. Trop. Dis."},{"key":"B27","unstructured":"Diagnostic target product profiles for monitoring, evaluation and surveillance of schistosomiasis control programmes2021"},{"volume-title":"Ending the neglect to attain the Sustainable Development Goals \u2013 A road map for neglected tropical diseases 2021\u20132030","year":"2020","key":"B28"},{"volume-title":"Report of the first meeting of the WHO diagnostic technical advisory group for neglected tropical diseases: Geneva, Switzerland, 30\u201331 October 2019","year":"2020","key":"B29"},{"key":"B30","unstructured":"Target product profile directory2023"},{"key":"B31","unstructured":"Schistosomiasis2023"}],"container-title":["Frontiers in Parasitology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpara.2023.1255848\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:40:15Z","timestamp":1695804015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpara.2023.1255848\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":31,"alternative-id":["10.3389\/fpara.2023.1255848"],"URL":"https:\/\/doi.org\/10.3389\/fpara.2023.1255848","relation":{},"ISSN":["2813-2424"],"issn-type":[{"type":"electronic","value":"2813-2424"}],"subject":[],"published":{"date-parts":[[2023,9,26]]},"article-number":"1255848"}}