{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:35:16Z","timestamp":1793093716915,"version":"4.5.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Parasitol."],"abstract":"<jats:p>\n                    A Ryukyu long-furred rat (\n                    <jats:italic>Diplothrix legata<\/jats:italic>\n                    ) rescued on Amami-Oshima Island, located in the southwestern Japan, exhibited neurological signs, including nystagmus and ataxia, and died six days after supportive treatment. Gross and histopathological examinations revealed nematodes in the brain, lungs, and heart. In the meninges, immature worm sections were associated with marked inflammatory thickening. Pulmonary lesions included adult worms, eggs, and larvae accompanied by hemorrhage, edema, thrombosis, and extensive necrosis with concurrent\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    infection. Mitochondrial cytochrome\n                    <jats:italic>c<\/jats:italic>\n                    oxidase 1 sequences obtained from the nematodes identified the ac1 lineage of\n                    <jats:italic>Angiostrongylus cantonensis<\/jats:italic>\n                    , a haplotype previously reported from mainland Japan and Amami-Oshima Island, but distinct from the lineage common on the neighboring islands of Okinawajima and Tokunoshima. This case supports the occurrence of angiostrongylosis in the Ryukyu long-furred rat and suggests that this species may manifest both neurological and respiratory disease manifestations. Further epidemiological investigations targeting invasive rodents of the genus\n                    <jats:italic>Rattus<\/jats:italic>\n                    , intermediate host, namely terrestrial gastropods (e.g., snails and slugs), and potential paratenic hosts (e.g., amphibians and reptiles), are warranted to clarify the transmission dynamics of\n                    <jats:italic>A. cantonensis<\/jats:italic>\n                    within the Amami Islands and to assess its potential impact on this endangered endemic rodent.\n                  <\/jats:p>","DOI":"10.3389\/fpara.2026.1797945","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:37:39Z","timestamp":1775828259000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Neurological and pulmonary angiostrongylosis in a Ryukyu long-furred rat (Diplothrix legata) on Amami-Oshima Island, Japan"],"prefix":"10.3389","volume":"5","author":[{"given":"So","family":"Shinya","sequence":"first","affiliation":[{"name":"Amami Wildlife Medical Center","place":["Amami, Kagoshima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Tokiwa","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Nippon Veterinary and Life Science University","place":["Musashino, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Nippon Veterinary and Life Science University","place":["Musashino, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University","place":["Musashino, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University","place":["Musashino, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryouta","family":"Torimoto","sequence":"additional","affiliation":[{"name":"Yuinoshima Animal Clinic","place":["Amami, Kagoshima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Muraoka","sequence":"additional","affiliation":[{"name":"Veterinarian Medical Development","place":["Adachi, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Physiological Pathology, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University","place":["Musashino, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1017\/S003118201600069X","article-title":"Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and Guinea pig models of human infection","volume":"143","author":"Aghazadeh","year":"2016","journal-title":"Parasitology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1017\/S0031182020001262","article-title":"Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations","volume":"148","author":"Ansdell","year":"2021","journal-title":"Parasitology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.4269\/ajtmh.2006.74.1122","article-title":"Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole","volume":"74","author":"Chotmongkol","year":"2006","journal-title":"Am. 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