{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:16:45Z","timestamp":1788419805337,"version":"build-2803163510"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Parasitol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hydatid disease caused by Echinococcus granulosus is a zoonosis endemic in many parts of the world. While hepatic and pulmonary involvements are common, isolated splenic hydatidosis remains extremely rare, representing less than 4% of all cases. Diagnosis can be further complicated by false-negative serological tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 31-year-old female presenting with isolated left upper quadrant pain. Physical examination and baseline laboratory tests were unremarkable. Abdominal ultrasound and computed tomography (CT) revealed a well-circumscribed, homogeneous, hypodense oval mass (50\u00d757\u00d756 mm) at the upper pole of the spleen with a thin wall displaying a focal calcification. Hydatid serology was negative. Given the high suspicion of a hydatid cyst, pre-splenectomy immunizations were administered, and the patient underwent an exploratory laparoscopy. Intraoperative findings confirmed a splenic hydatid cyst, and a total laparoscopic splenectomy was performed. The postoperative course was uneventful. Histopathological examination confirmed the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinicians should maintain a high index of suspicion for hydatid disease in patients presenting with cystic splenic masses in endemic areas, even in the presence of negative serology. Laparoscopic splenectomy is a safe and effective approach when strict hydatid safety measures are respected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpara.2026.1956525","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:45:03Z","timestamp":1788417903000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Isolated splenic hydatid cyst with negative serology managed by laparoscopic splenectomy"],"prefix":"10.3389","volume":"5","author":[{"given":"Amine Ben","family":"Safta","sequence":"first","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salsabil","family":"Nasri","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wejih","family":"Dougaz","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Alouani","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Ksentini","sequence":"additional","affiliation":[{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]},{"name":"Department of Pathology, Charles Nicolle Hospital","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hichem","family":"Jerraya","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi","family":"Nouira","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Charles Nicolle Hospital","place":["Tunis, Tunisia"]},{"name":"Universite de Tunis El Manar Faculte de Medecine de Tunis","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1007\/s11605-013-2303-5","article-title":"Hydatid disease of the spleen: single-center experience and a brief literature review","volume":"17","author":"Akbulut","year":"2013","journal-title":"J. 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