{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:39:21Z","timestamp":1787243961383,"version":"build-2736575974"},"reference-count":37,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2014.00092","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T05:22:54Z","timestamp":1409548974000},"source":"Crossref","is-referenced-by-count":5,"title":["GH Dysfunction in Engrailed-2 Knockout Mice, a Model for Autism Spectrum Disorders"],"prefix":"10.3389","volume":"2","author":[{"given":"Giovanni","family":"Provenzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha","family":"Genovesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Scali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem Prakash","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sgad\u00c3\u00b2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Bozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1177\/1073858408331371","article-title":"Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis","volume":"15","author":"Llorens-Mart\u00c3\u00adn","year":"2009","journal-title":"Neuroscientist"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1160","DOI":"10.1371\/journal.pone.0001160","article-title":"Maternal enrichment during pregnancy accelerates retinal development of the fetus","volume":"2","author":"Sale","year":"2007","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.tins.2008.12.004","article-title":"Enrich the environment to empower the brain","volume":"32","author":"Sale","year":"2009","journal-title":"Trends Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6042","DOI":"10.1523\/JNEUROSCI.5548-08.2009","article-title":"Massage accelerates brain development and the maturation of visual function","volume":"29","author":"Guzzetta","year":"2009","journal-title":"J Neurosci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/dneu.20778","article-title":"Toward a comprehensive neurobiology of IGF-I","volume":"70","author":"Torres-Aleman","year":"2010","journal-title":"Dev Neurobiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.mcn.2007.10.016","article-title":"The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis","volume":"37","author":"Trejo","year":"2008","journal-title":"Mol Cell Neurosci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.mcn.2010.02.006","article-title":"Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour","volume":"44","author":"Llorens-Mart\u00c3\u00adn","year":"2010","journal-title":"Mol Cell Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/sj.mp.4002076","article-title":"Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects","volume":"12","author":"Trejo","year":"2007","journal-title":"Mol Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1365-2265.2007.02868.x","article-title":"Elevated levels of growth-related hormones in autism and autism spectrum disorder","volume":"67","author":"Mills","year":"2007","journal-title":"Clin Endocrinol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1017\/S0012162201001116","article-title":"Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism","volume":"43","author":"Vanhala","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1017\/S0012162206001605","article-title":"Cerebrospinal fluid insulin-like growth factors IGF-1 and IGF-2 in infantile autism","volume":"48","author":"Riikonen","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijdevneu.2014.03.006","article-title":"Dysregulation of the IGF-I\/PI3K\/AKT\/mTOR signaling pathway in autism spectrum disorders","volume":"35C","author":"Chen","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature12618","article-title":"SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients","volume":"503","author":"Shcheglovitov","year":"2013","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1073\/pnas.0812394106","article-title":"Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice","volume":"106","author":"Tropea","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2040-2392-4-9","article-title":"Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay","volume":"4","author":"Bozdagi","year":"2013","journal-title":"Mol Autism"},{"key":"B16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nrendo.2013.78","article-title":"Growth hormone and cognitive function","volume":"9","author":"Nyberg","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2040-2392-2-16","article-title":"Investigation of the serum levels of anterior pituitary hormones in male children with autism","volume":"2","author":"Iwata","year":"2011","journal-title":"Mol Autism"},{"key":"B18","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.biopsych.2009.05.027","article-title":"Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2","volume":"66","author":"Benayed","year":"2009","journal-title":"Biol Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1038\/tp.2013.8","article-title":"Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum","volume":"3","author":"James","year":"2013","journal-title":"Transl Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e87208","DOI":"10.1371\/journal.pone.0087208","article-title":"Autism associated gene, Engrailed 2, and flanking gene levels are altered in post-mortem cerebellum","volume":"9","author":"Choi","year":"2014","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.1672471","article-title":"Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox","volume":"251","author":"Joyner","year":"1991","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.brainres.2006.07.086","article-title":"En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder","volume":"1116","author":"Cheh","year":"2006","journal-title":"Brain Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e40914","DOI":"10.1371\/journal.pone.0040914","article-title":"Autism-relevant social abnormalities and cognitive deficits in Engrailed-2 knockout mice","volume":"7","author":"Brielmaier","year":"2012","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/gbb.12115","article-title":"Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice","volume":"13","author":"Brielmaier","year":"2014","journal-title":"Genes Brain Behav"},{"key":"B25","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.neuroscience.2009.01.007","article-title":"Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice","volume":"159","author":"Tripathi","year":"2009","journal-title":"Neuroscience"},{"key":"B26","doi-asserted-by":"crossref","first-page":"7881","DOI":"10.1523\/JNEUROSCI.17-20-07881.1997","article-title":"Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development","volume":"17","author":"Kuemerle","year":"1997","journal-title":"J Neurosci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.expneurol.2013.01.021","article-title":"Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders","volume":"247","author":"Sgad\u00c3\u00b2","year":"2013","journal-title":"Exp Neurol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/2040-2392-4-51","article-title":"Transcriptome profiling in Engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders","volume":"4","author":"Sgad\u00c3\u00b2","year":"2013","journal-title":"Mol Autism"},{"key":"B29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2040-2392-5-9","article-title":"Engrailed 2 modulates cerebellar granule neuron precursor proliferation, differentiation and insulin-like growth factor 1 signaling during postnatal development","volume":"5","author":"Rossman","year":"2014","journal-title":"Mol Autism"},{"key":"B30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0896-6273(00)80352-9","article-title":"Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia","volume":"19","author":"Saiardi","year":"1997","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1210\/endo-127-1-365","article-title":"Gonadotropin-releasing hormone gene expression during the rat estrous cycle: effects of pentobarbital and ovarian steroids","volume":"127","author":"Park","year":"1990","journal-title":"Endocrinology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1073\/pnas.83.1.77","article-title":"Two insulin-like growth factor I messenger RNAs are expressed in human liver","volume":"83","author":"Rotwein","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fendo.2013.00039","article-title":"The regulation of IGF-1 gene transcription and splicing during development and aging","volume":"4","author":"Oberbauer","year":"2013","journal-title":"Front Endocrinol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"9343","DOI":"10.1073\/pnas.83.24.9343","article-title":"Regulation of insulin-like growth factor I gene expression by growth hormone","volume":"83","author":"Mathews","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nature03441","article-title":"Systematic discovery of regulatory motifs in human promoters and 3\u00e2\u20ac\u2122 UTRs by comparison of several mammals","volume":"434","author":"Xie","year":"2005","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1507\/endocrj.K11E-006","article-title":"Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats","volume":"58","author":"Li","year":"2011","journal-title":"Endocr J"},{"key":"B37","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fnbeh.2013.00066","article-title":"Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment","volume":"7","author":"Vander Weele","year":"2013","journal-title":"Front Behav Neurosci"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:42:47Z","timestamp":1565779367000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fped.2014.00092\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3389\/fped.2014.00092","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,1]]}}}