{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:27:26Z","timestamp":1788258446864,"version":"build-2803163510"},"reference-count":69,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2017.00131","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T03:44:58Z","timestamp":1496893498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Exercise-Induced Bronchospasm and Allergy"],"prefix":"10.3389","volume":"5","author":[{"given":"Serena","family":"Caggiano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Cutrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Turchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1399-3038.2011.01256.x","article-title":"Allergy and sports in children","volume":"23","author":"Del Giacco","year":"2012","journal-title":"Pediatr Allergy Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.anai.2010.09.021","article-title":"Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter","volume":"105","author":"Weiler","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1398-9995.2008.01662.x","article-title":"Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN","volume":"63","author":"Carlsen","year":"2008","journal-title":"Allergy"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.jaci.2016.05.029","article-title":"Exercise-induced bronchoconstriction update-2016","volume":"138","author":"Weiler","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1056\/NEJMra1407552","article-title":"Asthma and exercise-induced bronchoconstriction in athletes","volume":"372","author":"Boulet","year":"2015","journal-title":"N Engl J Med"},{"key":"B6","first-page":"45","article-title":"Asthma, exercise and the immune system","volume":"2","author":"Crimi","year":"1996","journal-title":"Exerc Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1183\/09031936.96.09081696","article-title":"Increased bronchial responsiveness to exercise as a risk factor for symptomatic asthma: findings from a longitudinal population study of children and adolescents","volume":"9","author":"Ulrik","year":"1996","journal-title":"Eur Respir J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1398-9995.2005.00938.x","article-title":"Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study","volume":"61","author":"Lodrup Carlsen","year":"2006","journal-title":"Allergy"},{"key":"B9","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.prrv.2013.11.009","article-title":"Beta-2 agonists for exercise-induced bronchoconstriction in children","volume":"15","author":"Bonini","year":"2014","journal-title":"Paediatr Respir Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S0140-6736(08)61447-6","article-title":"Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study","volume":"372","author":"Stern","year":"2008","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1034\/j.1398-9995.2001.056003215.x","article-title":"Allergy and sports","volume":"56","author":"Del Giacco","year":"2001","journal-title":"Allergy"},{"key":"B12","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1398-9995.2005.00938.x","article-title":"Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study","volume":"61","author":"L\u00f8drup Carlsen","year":"2006","journal-title":"Allergy"},{"key":"B13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.5539\/gjhs.v7n2p115","article-title":"Exercise-induced asthma in asthmatic children of southern Iran","volume":"7","author":"Fayezi","year":"2014","journal-title":"Glob J Health Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40733-015-0004-4","article-title":"Exercise-induced bronchoconstriction: new evidence in pathogenesis, diagnosis and treatment","volume":"1","author":"Bonini","year":"2015","journal-title":"Asthma Res Pract"},{"key":"B15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1586\/ers.12.33","article-title":"The prevention of exercise-induced bronchoconstriction: what are the options?","volume":"6","author":"Anderson","year":"2012","journal-title":"Expert Rev Respir Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.anai.2010.09.021","article-title":"Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter","volume":"105","author":"Weiler","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/pr.2012.202","article-title":"Exercise-induced bronchoconstriction in school-age children born extremely preterm","volume":"73","author":"Hamon","year":"2013","journal-title":"Pediatr Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1007\/s11882-013-0380-x","article-title":"Pediatric exercise-induced bronchoconstriction: contemporary developments in epidemiology, pathogenesis, presentation, diagnosis, and therapy","volume":"13","author":"Randolph","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/bjsports-2011-090810","article-title":"Assessment and prevention of exercise induced bronchoconstriction","volume":"46","author":"Anderson","year":"2012","journal-title":"Br J Sports Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1136\/thx.2005.045682","article-title":"Asthma prevalence in 1973, 1988 and 2003","volume":"61","author":"Burr","year":"2006","journal-title":"Thorax"},{"key":"B21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ppul.20185","article-title":"Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction","volume":"39","author":"De Baets","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1164\/rccm.201303-0437ST","article-title":"An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction","volume":"187","author":"Parsons","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3109\/02770903.2011.578315","article-title":"Prevalence rate of exercise-induced bronchoconstriction in Annaba (Algeria) schoolchildren","volume":"48","author":"Benarab-Boucherit","year":"2011","journal-title":"J Asthma"},{"key":"B24","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1590\/S0100-879X2002000300006","article-title":"Effect of asthma severity on symptom perception in childhood asthma","volume":"35","author":"Cabral","year":"2002","journal-title":"Braz J Med Biol Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2500\/aap.2012.33.3507","article-title":"Exercise-induced bronchoconstriction: burden and prevalence","volume":"33","author":"Khan","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.jaci.2010.03.003","article-title":"Accumulation of intraepithelial mast cells with a unique protease phenotype in T(h)2-high asthma","volume":"125","author":"Dougherty","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.prrv.2013.04.006","article-title":"Interleukins for the paediatric pulmonologist","volume":"15","author":"Rozycki","year":"2014","journal-title":"Paediatr Respir Rev"},{"key":"B28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1183\/1025448x.00033-003","article-title":"Exercise and airway physiology: interactions with immune and allergic responses","volume-title":"Diagnosis, Prevention and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports","author":"Palange","year":"2005"},{"key":"B29","doi-asserted-by":"publisher","first-page":"27984","DOI":"10.3402\/ecrj.v2.27984","article-title":"Exercise and asthma: an overview","volume":"2","author":"Del Giacco","year":"2015","journal-title":"Eur Clin Respir J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1067\/mai.2000.109822","article-title":"The mechanism of exercise-induced asthma is\u2026","volume":"106","author":"Anderson","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s11882-009-0003-8","article-title":"Role of leukotrienes in exercise-induced bronchoconstriction","volume":"9","author":"Hallstrand","year":"2009","journal-title":"Curr Allergy Asthma Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.jpeds.2012.09.040","article-title":"Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy","volume":"162","author":"Joshi","year":"2013","journal-title":"J Pediatr"},{"key":"B33","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1164\/rccm.200412-1667OC","article-title":"Inflammatory basis of exercise-induced bronchoconstriction","volume":"172","author":"Hallstrand","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/ACI.0b013e32834ecc67","article-title":"New insights into pathogenesis of exercise induced bronchoconstriction","volume":"12","author":"Hallstrand","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B35","first-page":"476","article-title":"Hyperpnea and heat flux: initial reaction sequence in exerciseinduced asthma","volume":"46","author":"Deal","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1249\/00005768-198025000-00012","article-title":"Cold air inhalation and esophageal temperature in exercising humans","volume":"12","author":"Jaeger","year":"1980","journal-title":"Med Sci Sports Exerc"},{"key":"B37","first-page":"467","article-title":"Role of respiratory heat exchange in production of exercise-induced asthma","volume":"46","author":"Deal","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"25e30","DOI":"10.1016\/j.rmed.2016.01.010","article-title":"School environmental factors are predictive for exercise-induced","volume":"112","author":"Stelmach","year":"2016","journal-title":"Respir Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e87155","DOI":"10.1371\/journal.pone.0087155","article-title":"What makes a difference in exercise-induced bronchoconstriction: an 8 year retrospective analysis","volume":"9","author":"Park","year":"2014","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4172\/2155-9899.1000202","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"5","author":"Bantz","year":"2014","journal-title":"J Clin Cell Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S0140-6736(08)61446-4","article-title":"Rhinitis and onset of asthma: a longitudinal population-based study","volume":"372","author":"Shaaban","year":"2008","journal-title":"Lancet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"B43","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/j.1365-2222.2004.01970.x","article-title":"Airway function and nasal inflammation in seasonal allergic rhinitis and asthma","volume":"34","author":"Ciprandi","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"B44","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jaci.2003.10.010","article-title":"Association between asthma and rhinitis according to atopic sensitization in a population-based study","volume":"113","author":"Leynaert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00405-009-1113-6","article-title":"Exercise-induced laryngeal obstructions objectively assessed using EILOMEA","volume":"267","author":"Christensen","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1136\/adc.2010.209411","article-title":"Monitoring pulmonary function during exercise in children with asthma","volume":"96","author":"van Leeuwen","year":"2011","journal-title":"Arch Dis Child"},{"key":"B47","unstructured":"Asthma. Exercise-Induced Bronchoconstriction (EIB)"},{"key":"B48","unstructured":"America- Exercise-Induced Bronchoconstriction Asthma"},{"key":"B49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1249\/JSR.0b013e31819c7b28","article-title":"Exercise-induced bronchospasm","volume":"8","author":"Storms","year":"2009","journal-title":"Curr Sports Med Rep"},{"key":"B50","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1378\/chest.127.3.839","article-title":"Methacholine challenge: comparison of two methods","volume":"127","author":"Cockcroft","year":"2005","journal-title":"Chest"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1465-9921-10-4","article-title":"Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma","volume":"10","author":"Anderson","year":"2009","journal-title":"Respir Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1111\/resp.12334","article-title":"Diagnostic properties of the methacholine and mannitol bronchial challenge tests: a comparison study","volume":"19","author":"Kim","year":"2014","journal-title":"Respirology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jaci.2008.06.014","article-title":"Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes","volume":"122","author":"Rundell","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1513\/AnnalsATS.201409-427OT","article-title":"Exercise-induced bronchoconstriction","volume":"11","author":"Pasnick","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"B55","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ppul.20340","article-title":"Applicability of interrupter resistance measurements for evaluation of exercise-induced bronchoconstriction in children","volume":"41","author":"Song","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1385\/CRIAI:31:2:163","article-title":"\u03b22-agonists and exercise-induced asthma","volume":"31","author":"Anderson","year":"2006","journal-title":"Clin Rev Allergy Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1385\/CRIAI:31:2:181","article-title":"Recovery from bronchoconstriction and bronchodilator tolerance","volume":"31","author":"Haney","year":"2006","journal-title":"Clin Rev Allergy Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S1081-1206(10)61377-4","article-title":"Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast","volume":"97","author":"Pearlman","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"97","DOI":"10.7326\/0003-4819-132-2-200001180-00002","article-title":"Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group","volume":"132","author":"Edelman","year":"2000","journal-title":"Ann Intern Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"CD002307","DOI":"10.1002\/14651858.CD002307","article-title":"Mast-cell stabilising agents to prevent exercise-induced bronchoconstriction","volume":"4","author":"Spooner","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"B61","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2500\/aap.2015.36.3810","article-title":"Prevalence of exercise-induced cough in schoolchildren: a pilot study","volume":"36","author":"Cichalewski","year":"2015","journal-title":"Allergy Asthma Proc"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/ppul.20672","article-title":"No differences in physical activity in (un)diagnosed asthma and healthy controls","volume":"42","author":"van Gent","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/bjsm.34.3.162","article-title":"Effects of physical training in asthma: a systematic review","volume":"34","author":"Ram","year":"2000","journal-title":"Br J Sports Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1191\/026921501678310162","article-title":"Children with asthma and physical exercise: effects of an exercise programme","volume":"15","author":"van Veldhoven","year":"2001","journal-title":"Clin Rehabil"},{"key":"B65","doi-asserted-by":"publisher","first-page":"127","DOI":"10.2165\/00007256-200535020-00003","article-title":"Effects of physical conditioning on children and adolescents with asthma","volume":"35","author":"Welsh","year":"2005","journal-title":"Sports Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1183\/09031936.00171707","article-title":"Physical training does not increase allergic inflammation in asthmatic children","volume":"32","author":"Moreira","year":"2008","journal-title":"Eur Respir J"},{"key":"B67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1155\/2014\/429248","article-title":"Exercise training, lymphocyte subsets and their cytokines production: experience of an Italian professional football team and their impact on allergy","volume":"2014","author":"Del Giacco","year":"2014","journal-title":"Biomed Res Int"},{"key":"B68","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S0091-6749(98)70173-3","article-title":"Asthma and increased bronchial responsiveness in elite athletes: atopy and sport event as risk factors","volume":"101","author":"Helenius","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"B69","volume-title":"Exercise-Induced Asthma","year":"2017"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fped.2017.00131\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:13:10Z","timestamp":1750295590000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fped.2017.00131\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,8]]},"references-count":69,"alternative-id":["10.3389\/fped.2017.00131"],"URL":"https:\/\/doi.org\/10.3389\/fped.2017.00131","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,8]]},"article-number":"131"}}