{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:15:15Z","timestamp":1784949315755,"version":"3.55.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2019.00075","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T08:32:36Z","timestamp":1553243556000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Attenuation of Acute Renal Injury After the Post-resuscitation Administration of Doxycycline in Surviving Newborn Piglets With Severe Hypoxia-Reoxygenation"],"prefix":"10.3389","volume":"7","author":[{"given":"Tze-Fun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo P.","family":"Pasquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/ije\/dyl043","article-title":"Estimating the causes of 4 million neonatal deaths in the year 2000","volume":"35","author":"Lawn","year":"2006","journal-title":"Int J Epidemiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"F152","DOI":"10.1136\/adc.2002.023093","article-title":"Multiorgan dysfunction in infants with post-asphyxial hypoxicischaemic encephalopathy","volume":"89","author":"Shah","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40200-015-0133-6","article-title":"Urinary biomarker N-acetyl-\u03b2-D-glucosaminidase can predict severity of renal damage in diabetic nephropathy","volume":"14","author":"Sheira","year":"2015","journal-title":"J Diabetes Metab Disord"},{"key":"B5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/tropej\/fmi017","article-title":"Evaluation of renal functions in asphyxiated newborns","volume":"51","author":"Aggarwal","year":"2005","journal-title":"J Trop Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1016\/j.jpeds.2010.11.010","article-title":"Acute kidney injury post neonatal asphyxia","volume":"158","author":"Durkan","year":"2011","journal-title":"J Pediatr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1053\/j.semperi.2008.01.003","article-title":"The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis","volume":"32","author":"Nankervis","year":"2008","journal-title":"Semin Perinatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0022-3476(88)80023-4","article-title":"Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome","volume":"113","author":"Perlman","year":"1988","journal-title":"J Pediatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/cvr\/cvp268","article-title":"Matrix metalloproteinase\u22122 and myocardial oxidative stress injury: beyond the matrix","volume":"85","author":"Kandasamy","year":"2010","journal-title":"Cardiovasc Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/sj.ki.5002715","article-title":"Urinary biomarkers in the early diagnosis of acute kidney injury","volume":"73","author":"Han","year":"2008","journal-title":"Kidney Int"},{"key":"B11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5527\/wjn.v2.i3.84","article-title":"Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases","volume":"2","author":"Zhao","year":"2013","journal-title":"World J Nephrol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/labinvest.2010.174","article-title":"Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury","volume":"91","author":"Kunugi","year":"2011","journal-title":"Lab Invest"},{"key":"B13","article-title":"Chapter 325: Rocky Mountain spotted fever","volume-title":"Textbook of Pediatric Care","author":"Seese","year":"2012"},{"key":"B14","doi-asserted-by":"publisher","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties","volume":"299","author":"Griffin","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jss.2009.09.048","article-title":"Effects of doxycycline on renal ischemia reperfusion injury induced by abdominal compartment syndrome","volume":"167","author":"Ihtiyar","year":"2011","journal-title":"J Surg Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF03179069","article-title":"Protective effects of doxycycline in ischemia\/reperfusion injury on kidney","volume":"65","author":"Kucuk","year":"2009","journal-title":"J Physiol Biochem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/SHK.0000000000000257","article-title":"Doxycycline attenuates renal injury in a swine model of neonatal hypoxia-reoxygenation","volume":"43","author":"LaBossiere","year":"2015","journal-title":"Shock."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/jn\/123.7.1248","article-title":"Development and validation of a total parenteral nutrition model in the neonatal piglet","volume":"123","author":"Wykes","year":"1993","journal-title":"J Nutr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/01.shk.0000158962.83529.ce","article-title":"Cardiac function, myocardial glutathione, and matrix metalloproteinase\u22122 levels in hypoxic newborn pigs reoxygenated by 21%, 50%, or 100% oxygen","volume":"23","author":"Haase","year":"2005","journal-title":"Shock."},{"key":"B22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1152\/jappl.1993.74.1.211","article-title":"Changes in regional blood flow distribution and oxygen supply during hypoxia in conscious rats","volume":"74","author":"Kuwahira","year":"1993","journal-title":"J Appl Physiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"B24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00075197-200203000-00009","article-title":"Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution","volume":"5","author":"Fink","year":"2002","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1007\/s00467-012-2185-x","article-title":"Are we ready for the clinical use of novel acute kidney injury biomarkers?","volume":"27","author":"Askenazi","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.18203\/2349-3291.ijcp20161052","article-title":"A study of multiorgan dysfunction in asphyxiated neonates","volume":"3","author":"Singh","year":"2016","journal-title":"Int J Contemp Pediatr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.17221\/8527-VETMED","article-title":"Urinary biomarkers of renal function in dogs and cats: a review","volume":"60","author":"Kovarikova","year":"2015","journal-title":"Vet Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1164\/rccm.200412-1740OC","article-title":"Room-air resuscitation causes less damage to heart and kidney than 100% oxygen","volume":"172","author":"Vento","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"F905","DOI":"10.1152\/ajprenal.00421.2006","article-title":"Role of matrix metalloproteinases in renal pathophysiologies","volume":"292","author":"Catania","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbadis.2017.10.005","article-title":"Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia\/reperfusion injury","volume":"1864","author":"Cortes","year":"2018","journal-title":"Biochim Biophys Acta."},{"key":"B31","doi-asserted-by":"publisher","first-page":"F280","DOI":"10.1152\/ajprenal.00351.2004","article-title":"Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases","volume":"289","author":"Covington","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1097\/CCM.0000000000000135","article-title":"Postresuscitation administration of doxycycline preserves cardiac function in hypoxia-reoxygenation injury of newborn piglets","volume":"42","author":"LaBossiere","year":"2014","journal-title":"Crit Care Med"},{"key":"B33","first-page":"11","article-title":"Comparative anatomy and physiology of the pig","volume":"25","author":"Swindle","year":"1998","journal-title":"Scand J Lab Anim Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anireprosci.2005.01.007","article-title":"Perinatal asphyxia pathophysiology in pig and human: a review","volume":"90","author":"Alonsospilsbury","year":"2005","journal-title":"Anim Reprod Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000151650","article-title":"Not all models are created equal: animal models to study hypoxic-ischemic encephalopathy of the newborn","volume":"94","author":"Chapados","year":"2008","journal-title":"Neonatology."},{"key":"B36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1365-2710.2007.00853.x","article-title":"Association between tetracycline or doxycycline and hepatotoxicity: a population based case-control study","volume":"32","author":"Heaton","year":"2007","journal-title":"J Clin Pharm Ther"},{"key":"B37","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1517\/14740338.7.5.571","article-title":"The use and safety of doxycycline hyclate and other second-generation tetracyclines","volume":"7","author":"Sloan","year":"2008","journal-title":"Expert Opin Drug Saf"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0157508","DOI":"10.1371\/journal.pone.0157508","article-title":"Protection of the transplant kidney from preservation injury by inhibition of matrix metalloproteinases","volume":"11","author":"Moser","year":"2016","journal-title":"PLoS One."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00075\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T08:32:38Z","timestamp":1553243558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00075\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":38,"alternative-id":["10.3389\/fped.2019.00075"],"URL":"https:\/\/doi.org\/10.3389\/fped.2019.00075","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]},"article-number":"75"}}