{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:37:03Z","timestamp":1781008623926,"version":"3.54.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2019.00185","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:52:47Z","timestamp":1557795167000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Healthcare Utilization in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS): Analysis of US Ambulatory Healthcare Data, 2000\u20132009"],"prefix":"10.3389","volume":"7","author":[{"given":"Jaeyong","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Mann S.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study","volume":"121","author":"Fukuda","year":"1994","journal-title":"Ann Intern Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.286.11.1360","article-title":"Interventions for the treatment and management of chronic fatigue syndrome","volume":"286","author":"Whiting","year":"2001","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1176\/appi.ajp.160.2.221","article-title":"Chronic fatigue syndrome: a review","volume":"160","author":"Afari","year":"2003","journal-title":"Am J Psychiatry."},{"key":"B4","unstructured":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness2015"},{"key":"B5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fped.2017.00121","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome diagnosis and management in young people: a primer","volume":"5","author":"Rowe","year":"2017","journal-title":"Front Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"871","DOI":"10.7326\/M15-0647","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome: a real illness","volume":"162","author":"Komaroff","year":"2015","journal-title":"Ann Intern Med."},{"key":"B7","first-page":"514","article-title":"Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community","volume":"107","author":"Price","year":"1992","journal-title":"Public Health Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1192\/bjp.166.6.793","article-title":"Chronic fatigue syndrome in the community","volume":"166","author":"Lawrie","year":"1995","journal-title":"Br J Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/135910539900400103","article-title":"A community-based study of prolonged fatigue and chronic fatigue","volume":"4","author":"Jason","year":"1999","journal-title":"J Health Psychol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1001\/archinte.153.24.2759","article-title":"Prevalence of fatigue and chronic fatigue syndrome in a primary care practice","volume":"153","author":"Bates","year":"1993","journal-title":"Arch Intern Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2105\/AJPH.87.9.1449","article-title":"The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study","volume":"87","author":"Wessely","year":"1997","journal-title":"Am J Public Health."},{"key":"B12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/occmed\/kqi012","article-title":"Epidemiology of chronic fatigue syndrome","volume":"55","author":"Ranjith","year":"2005","journal-title":"Occup Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1478-7954-5-5","article-title":"Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia","volume":"5","author":"Reeves","year":"2007","journal-title":"Popul Health Metr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1093\/ije\/dyp147","article-title":"A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping","volume":"38","author":"Dinos","year":"2009","journal-title":"Int J Epidemiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/1471-2458-11-402","article-title":"The functional status and well being of people with myalgic encephalomyelitis\/chronic fatigue syndrome and their carers","volume":"11","author":"Nacul","year":"2011","journal-title":"BMC Public Health."},{"key":"B16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/CLEP.S39876","article-title":"The prevalence of chronic fatigue syndrome\/myalgic encephalomyelitis: a meta-analysis","volume":"5","author":"Johnston","year":"2013","journal-title":"Clin Epidemiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"83S","DOI":"10.1016\/S0002-9343(98)00158-2","article-title":"The epidemiology of chronic fatigue in San Francisco","volume":"105","author":"Steele","year":"1998","journal-title":"Am J Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.mayocp.2012.08.015","article-title":"Prevalence, incidence, and classification of chronic fatigue syndrome in olmsted county, minnesota, as estimated using the rochester epidemiology project","volume":"87","author":"Vincent","year":"2012","journal-title":"Mayo Clin Proc."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1478-7547-2-4","article-title":"The economic impact of chronic fatigue syndrome","volume":"2","author":"Reynolds","year":"2004","journal-title":"Cost Effect Resource Allocation."},{"key":"B20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-5918-7-6","article-title":"The economic impact of ME\/CFS: individual and societal costs","volume":"7","author":"Jason","year":"2008","journal-title":"Dynamic Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1478-7547-9-1","article-title":"The economic impact of chronic fatigue syndrome in Georgia: direct and indirect costs","volume":"9","author":"Lin","year":"2011","journal-title":"Cost Effect Resource Allocation."},{"key":"B22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0002-9343(96)90012-1","article-title":"An examination of the working case definition of chronic fatigue syndrome","volume":"100","author":"Komaroff","year":"1996","journal-title":"Am J Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/art.1780330311","article-title":"High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice","volume":"33","author":"Goldenberg","year":"1990","journal-title":"Arthritis Rheum."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1001\/archinte.1994.00420180053007","article-title":"Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities","volume":"154","author":"Buchwald","year":"1994","journal-title":"Arch Intern Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/00006842-200009000-00009","article-title":"Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms","volume":"62","author":"Jason","year":"2000","journal-title":"Psychosom Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jpsychores.2012.09.002","article-title":"The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs","volume":"74","author":"Warren","year":"2013","journal-title":"J Psychosom Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.24095\/hpcdp.35.1.02","article-title":"Chronic fatigue syndrome and fibromyalgia in Canada: prevalence and associations with six health status indicators","volume":"35","author":"Rusu","year":"2015","journal-title":"Health Promot Chronic Dis Prev Can"},{"key":"B28","first-page":"1","article-title":"Patient experiences of depression and anxiety with chronic disease: a systematic review and qualitative meta-synthesis","volume":"13","author":"DeJean","year":"2013","journal-title":"Ont Health Technol Assess Ser."},{"key":"B29","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/PSY.0b013e31819ea179","article-title":"Psychiatric comorbidity in persons with chronic fatigue syndrome identified from the Georgia population","volume":"71","author":"Nater","year":"2009","journal-title":"Psychosom Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1046\/j.1525-1497.2001.03419.x","article-title":"Comorbid clinical conditions in chronic fatigue: a co-twin control study","volume":"16","author":"Aaron","year":"2001","journal-title":"J Gen Intern Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1472-6963-9-13","article-title":"Barriers to healthcare utilization in fatiguing illness: a population-based study in Georgia","volume":"9","author":"Lin","year":"2009","journal-title":"BMC Health Serv Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2296-11-28","article-title":"US healthcare providers' knowledge, attitudes, beliefs, and perceptions concerning Chronic Fatigue Syndrome","volume":"11","author":"Brimmer","year":"2010","journal-title":"BMC Family Pract."},{"key":"B33","unstructured":"Centers for Disease Control and Prevention, U.S. Department of Health and Human Services."},{"key":"B34","unstructured":"Centers for Disease Control and Prevention, U.S. Department of Health and Human Services."},{"key":"B35","first-page":"1","article-title":"Ambulatory medical care utilization estimates for 2007","volume":"169","author":"Schappert","year":"2011","journal-title":"Vital and Health Stat."},{"key":"B36","first-page":"1","article-title":"National hospital ambulatory medical care survey: 2007 outpatient department summary","volume":"28","author":"Hing","year":"2010","journal-title":"National Health Stat Rep."},{"key":"B37","first-page":"1","article-title":"National ambulatory medical care survey: 2007 summary","volume":"27","author":"Hsiao","year":"2010","journal-title":"National Health Stat Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/e587172010-001","article-title":"National hospital ambulatory medical care survey: 2007 emergency department summary","volume":"386","author":"Niska","year":"2010","journal-title":"Natl Health Stat Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1001\/archinte.165.12.1354","article-title":"Quality of US outpatient care: temporal changes and racial\/ethnic disparities","volume":"165","author":"Ma","year":"2005","journal-title":"Arch Intern Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s11606-014-2808-y","article-title":"Trends and quality of care in outpatient visits to generalist and specialist physicians delivering primary care in the United States, 1997-2010","volume":"29","author":"Edwards","year":"2014","journal-title":"J Gen Intern Med"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00185\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:52:53Z","timestamp":1557795173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00185\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":40,"alternative-id":["10.3389\/fped.2019.00185"],"URL":"https:\/\/doi.org\/10.3389\/fped.2019.00185","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"article-number":"185"}}