{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:22Z","timestamp":1762102402819,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2019.00197","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T09:07:52Z","timestamp":1558516072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Plasma Zonulin Levels in Childhood Nephrotic Syndrome"],"prefix":"10.3389","volume":"7","author":[{"given":"Howard","family":"Trachtman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie S.","family":"Gipson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin V.","family":"Lemley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Troost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Faul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Vento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-hyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith D.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(03)14184-0","article-title":"Nephrotic syndrome in childhood","volume":"362","author":"Eddy","year":"2003","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1542\/peds.2008-1559","article-title":"Management of childhood onset nephrotic syndrome","volume":"124","author":"Gipson","year":"2009","journal-title":"Pediatrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1681\/ASN.2017111185","article-title":"Transethnic, genome-wide analysis reveals immune-related risk alleles and phenotypic correlates in pediatric steroid-sensitive nephrotic syndrome","volume":"29","author":"Debiec","year":"2018","journal-title":"J Am Soc Nephrol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1681\/ASN.2017080859","article-title":"Strong association of the HLA-DR\/DQ locus with childhood steroid-sensitive nephrotic syndrome in the Japanese population","volume":"29","author":"Jia","year":"2018","journal-title":"J Am Soc Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/archdischild-2015-308924","article-title":"Steroid-sensitive nephrotic syndrome: an evidence-based update of immunosuppressive treatment in children","volume":"101","author":"Larkins","year":"2016","journal-title":"Arch Dis Child."},{"key":"B6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00467-015-3082-x","article-title":"The glomerular permeability factors in idiopathic nephrotic syndrome","volume":"31","author":"Davin","year":"2016","journal-title":"Pediatr Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fmed.2018.00055","article-title":"Monogenic causes of proteinuria in children","volume":"5","author":"Cil","year":"2018","journal-title":"Front Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S0140-6736(77)92603-4","article-title":"Severe steroid-responsive nephrosis associated with hypersensitivity","volume":"1","author":"Sandberg","year":"1977","journal-title":"Lancet."},{"key":"B9","first-page":"S147","article-title":"Food allergy and idiopathic nephrotic syndrome","volume":"27","author":"Lagrue","year":"1989","journal-title":"Kidney Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000184448","article-title":"Is adult idiopathic nephrotic syndrome food allergy? Value of oligoantigenic diets","volume":"47","author":"Laurent","year":"1987","journal-title":"Nephron."},{"key":"B11","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/pr.2014.159","article-title":"Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome","volume":"77","author":"Uy","year":"2015","journal-title":"Pediatr Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e20154528","DOI":"10.1542\/peds.2015-4528","article-title":"The effect of a gluten-free diet in children with difficult-to-manage nephrotic syndrome","volume":"138","author":"Lemley","year":"2016","journal-title":"Pediatrics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1001\/jamapediatrics.2013.3858","article-title":"Celiac disease","volume":"168","author":"Guandalini","year":"2014","journal-title":"A Review. JAMA Pediatrics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1586\/1744666X.2013.850029","article-title":"Celiac disease and endocrine autoimmune disorders in children: an update","volume":"9","author":"Diamanti","year":"2013","journal-title":"Expert Rev Clin Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/10611860600613316","article-title":"Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin","volume":"14","author":"Motlekar","year":"2006"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16799","DOI":"10.1073\/pnas.0906773106","article-title":"Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2","volume":"106","author":"Tripathi","year":"2009","journal-title":"Proc Natl Acad Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1182\/blood-2011-07-365973","article-title":"Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes","volume":"119","author":"Madhusudhan","year":"2012","journal-title":"Blood."},{"key":"B19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ijpharm.2008.08.047","article-title":"Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer","volume":"365","author":"Gopalakrishnan","year":"2009","journal-title":"Int J Pharm"},{"key":"B20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.peptides.2012.02.015","article-title":"Larazotide acetate regulates epithelial tight junctions in vitro and in vivo","volume":"35","author":"Gopalakrishnan","year":"2012","journal-title":"Peptides"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1681\/ASN.2017020143","article-title":"The evolving complexity of the podocyte cytoskeleton","volume":"28","author":"Schell","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/ki.2012.428","article-title":"Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach","volume":"83","author":"Gadegbeku","year":"2013","journal-title":"Kidney Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.ekir.2018.06.002","article-title":"Consent for Genetic Biobanking in a Diverse Multisite CKD Cohort","volume":"3","author":"Jonathan","year":"2018","journal-title":"Kidney Int Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/annrheumdis-2016-210000","article-title":"Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis","volume":"76","author":"Ciccia","year":"2017","journal-title":"Ann Rheum Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1089\/jmf.2017.0069","article-title":"The occurrence of antibodies against gluten in children with autism spectrum disorders does not correlate with serological markers of impaired intestinal permeability","volume":"21","author":"J\u00f3zefczuk","year":"2017","journal-title":"J Med Food."},{"key":"B26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11255-017-1741-5","article-title":"Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease","volume":"50","author":"Lukaszyk","year":"2018","journal-title":"Int Urol Nephrol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5669","DOI":"10.3748\/wjg.v23.i31.5669","article-title":"Fluctuation of zonulin levels in blood vs stability of antibodies. Fluctuation of zonulin levels in blood vs stability of antibodies","volume":"23","author":"Vojdani","year":"2017","journal-title":"World J Gastroenterol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.11613\/BM.2013.013","article-title":"Increased plasma zonulin in patients with sepsis","volume":"23","author":"Klaus","year":"2013","journal-title":"Biochem Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1530\/EJE-14-0589","article-title":"Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation","volume":"172","author":"Zhang","year":"2015","journal-title":"Eur J Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"E582","DOI":"10.3390\/ijms18030582","article-title":"Higher levels of serum zonulin may rather be associated with increased risk of obesity and hyperlipidemia, than with gastrointestinal symptoms or disease manifestations","volume":"18","author":"Ohlsson","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.aah5298","article-title":"Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease","volume":"356","author":"Bouziat","year":"2017","journal-title":"Science."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00197\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T09:07:54Z","timestamp":1558516074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00197\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":31,"alternative-id":["10.3389\/fped.2019.00197"],"URL":"https:\/\/doi.org\/10.3389\/fped.2019.00197","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2019,5,16]]},"article-number":"197"}}