{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:59:51Z","timestamp":1781870391590,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2019.00534","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T08:53:00Z","timestamp":1579251180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Early Clinical Predictors of Neurological Outcome in Children With Asphyxial Out-of-Hospital Cardiac Arrest Treated With Therapeutic Hypothermia"],"prefix":"10.3389","volume":"7","author":[{"given":"Jainn-Jim","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hsuan","family":"Hsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Chang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei-Shyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hsin","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chou","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1161\/CIR.0000000000000313","article-title":"Temperature management after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation","volume":"132","author":"Donnino","year":"2015","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1056\/NEJMoa1411480","article-title":"THAPCA trial investigators. Therapeutic hypothermia after out-of-hospital cardiac arrest in children","volume":"372","author":"Moler","year":"2015","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.resuscitation.2018.08.019","article-title":"iCNS Group. 72-h therapeutic hypothermia improves neurological outcomes in paediatric asphyxial out-of-hospital cardiac arrest-An exploratory investigation","volume":"133","author":"Lin","year":"2018","journal-title":"Resuscitation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1016\/S0140-6736(98)04076-8","article-title":"Systematic review of early prediction of poor outcome in anoxic-ischaemic coma","volume":"352","author":"Zandbergen","year":"1998","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.7326\/ACPJC-2004-141-2-049","article-title":"Review: 4 clinical signs are precise and accurate for predicting poor outcome in post cardiac arrest coma","volume":"141","author":"Ballew","year":"2004","journal-title":"ACP J Club"},{"key":"B6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/01.PCC.0000288714.61037.56","article-title":"Predicting outcome in children with hypoxic ischemic encephalopathy","volume":"9","author":"Abend","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.resuscitation.2011.12.036","article-title":"Prediction protocol for neurological outcome for survivors of out-of-hospital cardiac arrest treated with targeted temperature management","volume":"83","author":"Okada","year":"2012","journal-title":"Resuscitation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.resuscitation.2012.03.003","article-title":"Therapeutic hypothermia after return of spontaneous circulation: should be offered to all?","volume":"83","author":"Szpilman","year":"2012","journal-title":"Resuscitation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"R147","DOI":"10.1186\/cc12826","article-title":"Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU","volume":"17","author":"Lindner","year":"2013","journal-title":"Crit Care"},{"key":"B10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13054-017-1677-2","article-title":"Early predictors of poor outcome after out-of-hospital cardiac arrest","volume":"21","author":"Martinell","year":"2017","journal-title":"Crit Care"},{"key":"B11","doi-asserted-by":"publisher","first-page":"R133","DOI":"10.1186\/cc13951","article-title":"Decision tree model for predicting long-term outcomes in children with out-of-hospital cardiacarrest: a nationwide, population-based observational study","volume":"18","author":"Goto","year":"2014","journal-title":"Crit Care"},{"key":"B12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.pediatrneurol.2012.12.021","article-title":"Therapeutic hypothermia associated with increased survival after resuscitation in children","volume":"48","author":"Lin","year":"2013","journal-title":"Pediatr Neurol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.resuscitation.2015.01.029","article-title":"Transcranial Doppler ultrasound in therapeutic hypothermia for children after resuscitation","volume":"89","author":"Lin","year":"2015","journal-title":"Resuscitation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/PCC.0b013e3182196a7b","article-title":"Outcome prediction by motor and pupillary responses in children treated with therapeutic hypothermia after cardiac arrest","volume":"13","author":"Abend","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.resuscitation.2015.12.012","article-title":"Effect of therapeutic hypothermia on the outcomes after out-of-hospital cardiac arrest according to initial ECG rhythm and witnessed status: A nationwide observational interaction analysis","volume":"100","author":"Choi","year":"2016","journal-title":"Resuscitation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.resuscitation.2010.10.026","article-title":"Blood ammonia and lactate levels on hospital arrival as a predictive biomarker in patients with out-of-hospital cardiac arrest","volume":"82","author":"Shinozaki","year":"2011","journal-title":"Resuscitation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.resuscitation.2014.11.005","article-title":"Correlation between initial serum levels of lactate after return of spontaneous circulation and survival and neurological outcomes in patients who undergo therapeutic hypothermia after cardiac arrest","volume":"88","author":"Lee","year":"2015","journal-title":"Resuscitation"},{"key":"B18","doi-asserted-by":"publisher","first-page":"8014213","DOI":"10.1155\/2018\/8014213","article-title":"Blood lactate or lactate clearance: which is robust to predict the neurological outcomes after cardiac arrest? a systematic review and meta-analysis","volume":"2018","author":"Zhou","year":"2018","journal-title":"Biomed Res Int"},{"key":"B19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.pedneo.2015.04.008","article-title":"serum lactate, brain magnetic resonance imaging and outcome of neonatal hypoxic ischemic encephalopathy after therapeutic hypothermia","volume":"57","author":"Chiang","year":"2016","journal-title":"Pediatr Neonatol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1212\/01.wnl.0000227183.21314.cd","article-title":"Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"67","author":"Wijdicks","year":"2006","journal-title":"Neurology."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00534\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T08:53:03Z","timestamp":1579251183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2019.00534\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":20,"alternative-id":["10.3389\/fped.2019.00534"],"URL":"https:\/\/doi.org\/10.3389\/fped.2019.00534","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]},"article-number":"534"}}