{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:02:55Z","timestamp":1791432175544,"version":"4.3.3"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00117","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:33:00Z","timestamp":1587529980000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Brain Abscess as Severe Presentation of Specific Granule Deficiency"],"prefix":"10.3389","volume":"8","author":[{"given":"Maria","family":"Leszcynska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhumika","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wil","family":"Chamizo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Tuite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Potthast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Leiding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,22]]},"reference":[{"key":"B1","first-page":"413","article-title":"Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection by immunoperoxidase staining for lactoferrin and cytochemical electron microscopy","volume":"99","author":"Breton-Gorius","year":"1980","journal-title":"Am J Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1182\/blood.V59.6.1317.1317","article-title":"Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response","volume":"59","author":"Gallin","year":"1982","journal-title":"Blood."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1084\/jem.189.11.1847","article-title":"Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT\/enhancer binding protein epsilon","volume":"189","author":"Lekstrom-Himes","year":"1999","journal-title":"J Exp Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/bjh.12207","article-title":"Neutrophil-specific granule deficiency","volume":"160","author":"McIlwaine","year":"2013","journal-title":"Br J Haematol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3389\/fimmu.2018.00588","article-title":"CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils","volume":"9","author":"Serwas","year":"2018","journal-title":"Front Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4049\/jimmunol.1402222","article-title":"A novel in-frame deletion in the leucine zipper domain of C\/EBPepsilon leads to neutrophil-specific granule deficiency","volume":"195","author":"Wada","year":"2015","journal-title":"J Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1136\/gut.2005.081927","article-title":"Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation","volume":"55","author":"Wynn","year":"2006","journal-title":"Gut."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1182\/blood.V97.9.2561","article-title":"Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT\/enhancer binding protein\u2013epsilon","volume":"97","author":"Gombart","year":"2001","journal-title":"Blood."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1182\/blood-2005-05-022004","article-title":"Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C\/EBPepsilon gene","volume":"109","author":"Khanna-Gupta","year":"2007","journal-title":"Blood."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1182\/blood.V94.9.3141.421k41_3141_3150","article-title":"Myeloid transcription factor C\/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils","volume":"94","author":"Verbeek","year":"1999","journal-title":"Blood."},{"key":"B11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00062752-200201000-00007","article-title":"Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C\/EBP(epsilon)","volume":"9","author":"Gombart","year":"2002","journal-title":"Curr Opin Hematol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF00915283","article-title":"Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections","volume":"4","author":"Ambruso","year":"1984","journal-title":"J Clin Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1056\/NEJM198208123070704","article-title":"Lactoferrin deficiency associated with altered granulocyte function","volume":"307","author":"Boxer","year":"1982","journal-title":"N Engl J Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3389\/fimmu.2017.01009","article-title":"Neutrophil evolution and their diseases in humans","volume":"8","author":"Leiding","year":"2017","journal-title":"Front Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1042\/bj20020508","article-title":"CCAAT\/enhancer-binding proteins: structure, function and regulation","volume":"365","author":"Ramji","year":"2002","journal-title":"Biochem J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1182\/blood.V82.1.268.bloodjournal821268","article-title":"Neutrophil-specific granule deficiency includes eosinophils","volume":"82","author":"Rosenberg","year":"1993","journal-title":"Blood."},{"key":"B17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1189\/jlb.0203063","article-title":"Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency","volume":"75","author":"Shiohara","year":"2004","journal-title":"J Leukoc Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1007\/s10875-014-0082-8","article-title":"Clinical course in a patient with neutrophil-specific granule deficiency and rapid detection of neutrophil granules as a screening test","volume":"34","author":"Shigemura","year":"2014","journal-title":"J Clin Immunol."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00117\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:33:01Z","timestamp":1587529981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00117\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":18,"alternative-id":["10.3389\/fped.2020.00117"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00117","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,22]]},"article-number":"117"}}