{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:14:39Z","timestamp":1775978079885,"version":"3.50.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004810","name":"Samfundet Folkh\u00e4lsan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010119","name":"Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkl\u00e9ns Minne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010119","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00145","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T14:21:16Z","timestamp":1586269276000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children"],"prefix":"10.3389","volume":"8","author":[{"given":"Petra","family":"Loid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Pekkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Mustila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Viljakainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"J\u00fcppner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1002\/jbmr.3450","article-title":"Genetic and epigenetic defects at the GNAS locus lead to distinct patterns of skeletal growth but similar early-onset obesity","volume":"33","author":"Hanna","year":"2018","journal-title":"J Bone Miner Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1210\/jc.2017-00395","article-title":"Early-onset obesity: unrecognized first evidence for GNAS mutations and methylation changes","volume":"102","author":"Gruters-Kieslich","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.ecl.2018.07.011","article-title":"Pseudohypoparathyroidism","volume":"47","author":"Linglart","year":"2018","journal-title":"Endocrinol Metab Clin North"},{"key":"B4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.beem.2018.01.002","article-title":"Multiple hormone resistance and alterations of G-protein-coupled receptors signaling","volume":"32","author":"Mantovani","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.4274\/jcrpe.2743","article-title":"Pseudohypoparathyroidism type 1A-subclinical hypothyroidism and rapid weight gain as early clinical signs: a clinical review of 10 cases","volume":"8","author":"Kayemba-Kay's","year":"2016","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1210\/jc.2015-3895","article-title":"Resting energy expenditure is decreased in pseudohypoparathyroidism type 1A","volume":"101","author":"Roizen","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1172\/JCI88622","article-title":"Gsalpha deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsalpha mutations","volume":"127","author":"Chen","year":"2017","journal-title":"J Clin Invest"},{"key":"B8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/MED.0000000000000306","article-title":"Nonclassic features of pseudohypoparathyroidism type 1A","volume":"24","author":"Shoemaker","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1002\/ajmg.a.37818","article-title":"Macrosomia, obesity, and macrocephaly as first clinical presentation of PHP1b caused by STX16 deletion","volume":"170","author":"de Lange","year":"2016","journal-title":"Am J Med Genet A"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1038\/s41598-017-03054-8","article-title":"Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity","volume":"7","author":"Hendricks","year":"2017","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3109\/07853890.2010.515603","article-title":"New Finnish growth references for children and adolescents aged 0 to 20 years: length\/height-for-age, weight-for-length\/height, and body mass index-for-age","volume":"43","author":"Saari","year":"2011","journal-title":"Ann Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/ejhg.2014.127","article-title":"European guidance for the molecular diagnosis of pseudohypoparathyroidism not caused by point genetic variants at GNAS: an EQA study","volume":"23","author":"Garin","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41574-018-0042-0","article-title":"Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement","volume":"14","author":"Mantovani","year":"2018","journal-title":"Nat Rev Endocrinol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00145\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T14:21:19Z","timestamp":1586269279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00145\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":13,"alternative-id":["10.3389\/fped.2020.00145"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00145","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]},"article-number":"145"}}