{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:03Z","timestamp":1753892043780,"version":"3.41.2"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00254","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T04:20:45Z","timestamp":1589948445000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Massive Hydrothorax and Ascites as the Primary Manifestation of Infection With Clostridium difficile: A Case Report and Literature Review"],"prefix":"10.3389","volume":"8","author":[{"given":"Yujian","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.tim.2014.04.003","article-title":"Clostridium difficile spore biology: sporulation, germination, and spore structural proteins","volume":"22","author":"Paredes-Sabja","year":"2014","journal-title":"Trends Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1056\/NEJMra1403772","article-title":"Clostridium difficile infection","volume":"372","author":"Leffler","year":"2015","journal-title":"New Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3760\/cma.j.issn.0253-2727.2013.12.008","article-title":"[Outcome of children and adolescents with Burkitt lymphoma and diffuse large B cell lymphoma treated with a modified NHL-BFM-90 protocol]","volume":"34","author":"Sun","year":"2013","journal-title":"Zhonghua xue ye xue za zhi"},{"key":"B4","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3343\/alm.2015.35.4.404","article-title":"Isolation and identification of Clostridium difficile using ChromID C. difficile medium combined with gram staining and PRO disc testing: a proposal for a simple culture process","volume":"35","author":"Park","year":"2015","journal-title":"Ann Lab Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1186\/s12864-016-2965-y","article-title":"Gastrointestinal microbial populations can distinguish pediatric and adolescent acute lymphoblastic leukemia (ALL) at the time of disease diagnosis","volume":"17","author":"Rajagopala","year":"2016","journal-title":"BMC Genomics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment Pharm Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.2174\/0929867323666161028162018","article-title":"Clostridium difficile infection: associations with chemotherapy, radiation therapy, and targeting therapy treatments","volume":"23","author":"Peretz","year":"2016","journal-title":"Curr Med Chem"},{"key":"B8","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1053\/gast.1997.v112.pm9041262","article-title":"Low albumin gradient ascites complicating severe pseudomembranous colitis","volume":"112","author":"Zuckerman","year":"1997","journal-title":"Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1099\/jmm.0.000028","article-title":"Risk factors, outcomes and epidemiology associated with Clostridium difficile infection in patients with haematological malignancies in a tertiary care hospital in China","volume":"64","author":"Gu","year":"2015","journal-title":"J Med Microbiol."},{"key":"B10","first-page":"244","article-title":"Cirrhotic gastrointestinal bleeding with Clostridium difficile infection: a case report","volume":"112","author":"Pang","year":"2015","journal-title":"Infectious Dis Inform."},{"key":"B11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1017\/ice.2015.234","article-title":"Rising incidence of Clostridium difficile-related discharges among hospitalized children in the United States","volume":"37","author":"Pant","year":"2016","journal-title":"Infect Control Hosp Epidemiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1097\/00006454-198912000-00010","article-title":"Severe pseudomembranous enterocolitis in a child: case report and literature review","volume":"8","author":"Zwiener","year":"1989","journal-title":"Pediatr Infect Dis J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ejim.2006.09.034","article-title":"A case of pseudomembranous colitis presenting with massive ascites","volume":"18","author":"Tsourous","year":"2007","journal-title":"Eur J Intern Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nrgastro.2009.105","article-title":"Fulminant Clostridium difficile-associated pouchitis with a fatal outcome","volume":"6","author":"Shen","year":"2009","journal-title":"Nat Rev Gastro Hepat."},{"key":"B15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/bf02236993","article-title":"Pseudomembranous colitis: report of a severe case with unusual clinical signs in a young nurse","volume":"43","author":"Boaz","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"B16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.yapd.2019.03.010","article-title":"Clostridium difficile infection in children","volume":"66","author":"Alvarez","year":"2019","journal-title":"Adv Pediatr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1093\/cid\/cir404","article-title":"Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections","volume":"53","author":"Mullane","year":"2011","journal-title":"Clin Infect Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/cix1085","article-title":"Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the INFECTIOUS DISEASES SOCIETY of America (IDSA) and society for healthcare epidemiology of America (SHEA)","volume":"66","author":"McDonald","year":"2018","journal-title":"Clin Infect Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"102098","DOI":"10.1016\/j.anaerobe.2019.102098","article-title":"Prevention of recurrent Clostridioides difficile infection: a systematic review of randomized controlled trials","volume":"61","author":"Madoff","year":"2019","journal-title":"Anaerobe"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.2146\/ajhp140359","article-title":"Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection","volume":"72","author":"Shah","year":"2015","journal-title":"Am J Health Syst Pharm"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00254\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T04:20:49Z","timestamp":1589948449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00254\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":20,"alternative-id":["10.3389\/fped.2020.00254"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00254","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"article-number":"254"}}