{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:28:08Z","timestamp":1776349688971,"version":"3.51.2"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1084254"],"award-info":[{"award-number":["1084254"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1105526"],"award-info":[{"award-number":["1105526"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1159120"],"award-info":[{"award-number":["1159120"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00268","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:14:59Z","timestamp":1590556499000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Cerebral Hemodynamic Response to Pain in Preterm Infants With Fetal Growth Restriction"],"prefix":"10.3389","volume":"8","author":[{"given":"Laura M. L.","family":"Dix","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsee","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme R.","family":"Polglase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1001\/jama.300.1.60","article-title":"Epidemiology and treatment of painful procedures in neonates in intensive care units","volume":"300","author":"Carbajal","year":"2008","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.5414\/CP202561","article-title":"Neonatal pain management: still in search for the Holy Grail","volume":"54","author":"Allegaert","year":"2016","journal-title":"Int J Clin Pharmacol Ther"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.1371\/journal.pmed.0050129","article-title":"How well do clinical pain assessment tools reflect pain in infants?","volume":"5","author":"Slater","year":"2008","journal-title":"PLoS Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"ENEURO","DOI":"10.1523\/ENEURO.0026-16.2016","article-title":"Mapping cortical responses to somatosensory stimuli in human infants with simultaneous near-infrared spectroscopy and event-related potential recording","volume":"3","author":"Verriotis","year":"2016","journal-title":"eNeuro"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1523\/JNEUROSCI.0348-06.2006","article-title":"Cortical pain responses in human infants","volume":"26","author":"Slater","year":"2006","journal-title":"J Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pain.2006.01.015","article-title":"Pain activates cortical areas in the preterm newborn brain","volume":"122","author":"Bartocci","year":"2006","journal-title":"Pain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1203\/00006450-199500000-00010","article-title":"Sucrose reduces pain reaction to heel lancing in preterm infants: a placebo-controlled, randomized and masked study","volume":"38","author":"Bucher","year":"1995","journal-title":"Pediatric Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/00004647-200003000-00005","article-title":"Noninvasive functional imaging of human brain using light","volume":"20","author":"Benaron","year":"2000","journal-title":"J Cerebral Blood Flow Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J Physiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1139\/y96-082","article-title":"Arterial remodeling: relation to hemodynamics","volume":"74","author":"Langille","year":"1996","journal-title":"Can J Physiol Pharmacol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ijdevneu.2015.01.004","article-title":"Cerebrovascular adaptations to chronic hypoxia in the growth restricted lamb","volume":"45","author":"Castillo-Melendez","year":"2015","journal-title":"Int J Dev Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1136\/bmj.298.6687.1561","article-title":"Fetal haemodynamic response to acute maternal hyperoxygenation as predictor of fetal distress in intrauterine growth retardation","volume":"298","author":"Arduini","year":"1989","journal-title":"BMJ"},{"key":"B13","doi-asserted-by":"publisher","first-page":"F156","DOI":"10.1136\/archdischild-2015-308843","article-title":"Growth restriction and gender influence cerebral oxygenation in preterm neonates","volume":"101","author":"Cohen","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000448873","article-title":"Reduction in cerebral oxygenation due to patent ductus arteriosus is pronounced in small-for-gestational-age neonates","volume":"111","author":"Cohen","year":"2017","journal-title":"Neonatology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000353631","article-title":"Neurodevelopment after fetal growth restriction","volume":"36","author":"Baschat","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"B16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000438451","article-title":"Brain-sparing in intrauterine growth restriction: considerations for the neonatologist","volume":"108","author":"Cohen","year":"2015","journal-title":"Neonatology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"F467","DOI":"10.1136\/archdischild-2017-313712e","article-title":"Cerebrovascular autoregulation in preterm fetal growth restricted neonates","volume":"104","author":"Cohen","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1159\/000101063","article-title":"Use of tissue oxygenation index and fractional tissue oxygen extraction as non-invasive parameters for cerebral oxygenation. A validation study in piglets","volume":"92","author":"Naulaers","year":"2007","journal-title":"Neonatology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"Hadlock","year":"1991","journal-title":"Radiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1089\/neu.2010.1388","article-title":"Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients","volume":"27","author":"Zweifel","year":"2010","journal-title":"J Neurotrauma"},{"key":"B21","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.braindev.2013.06.006","article-title":"Comparison of changes in cerebral and systemic perfusion between appropriate- and small-for-gestational-age infants during the first three days after birth","volume":"36","author":"Ishii","year":"2014","journal-title":"Brain Dev"},{"key":"B22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0887-8994(94)90009-4","article-title":"Cerebral blood flow in preterm infants affected by sex, mechanical ventilation, and intrauterine growth","volume":"11","author":"Baenziger","year":"1994","journal-title":"Pediatr Neurol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0028-2243(86)90141-3","article-title":"Decreased cerebrovascular resistance in small for gestational age infants","volume":"23","author":"van Bel","year":"1986","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/BF02014966","article-title":"Blood flow velocities in the cerebral arteries and descending aorta in small-for-dates infants","volume":"23","author":"Nishimaki","year":"1993","journal-title":"Pediatr Radiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/uog.14930","article-title":"Fetal cardiac function in late-onset intrauterine growth restriction vs small-for-gestational age, as defined by estimated fetal weight, cerebroplacental ratio and uterine artery doppler","volume":"46","author":"Perez-Cruz","year":"2015","journal-title":"Ultrasound Obstet Gynecol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/pr.2016.24","article-title":"Intrauterine growth restriction: impact on cardiovascular development and function throughout infancy","volume":"79","author":"Cohen","year":"2016","journal-title":"Pediatr Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jpeds.2017.05.076","article-title":"Cardiac morphology and function in preterm growth restricted infants: relevance for clinical sequelae","volume":"188","author":"Sehgal","year":"2017","journal-title":"J Pediatr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1203\/00006450-199404000-00022","article-title":"Heart rate and heart rate variability during sleep in small-for-gestational age newborns","volume":"35","author":"Spassov","year":"1994","journal-title":"Pediatr Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4380","DOI":"10.1073\/pnas.1212785110","article-title":"Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain","volume":"110","author":"Kozberg","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.neuroimage.2012.06.054","article-title":"Development of BOLD signal hemodynamic responses in the human brain","volume":"63","author":"Arichi","year":"2012","journal-title":"NeuroImage"},{"key":"B31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuroimage.2005.07.024","article-title":"Somatosensory lateralization in the newborn brain","volume":"29","author":"Erberich","year":"2006","journal-title":"NeuroImage"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.neuroimage.2009.10.038","article-title":"Somatosensory cortical activation identified by functional MRI in preterm and term infants","volume":"49","author":"Arichi","year":"2010","journal-title":"NeuroImage"},{"key":"B33","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1152\/jn.1997.78.2.651","article-title":"Local and propagated vascular responses evoked by focal synaptic activity in cerebellar cortex","volume":"78","author":"Iadecola","year":"1997","journal-title":"J Neurophysiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/glia.440060207","article-title":"Postnatal development of dye-coupling among astrocytes in rat visual cortex","volume":"6","author":"Binmoller","year":"1992","journal-title":"Glia"},{"key":"B35","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1203\/01.PDR.0000128983.54614.7E","article-title":"Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction","volume":"56","author":"Tolsa","year":"2004","journal-title":"Pediatr Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1093\/brain\/awn137","article-title":"Primary cortical folding in the human newborn: an early marker of later functional development","volume":"131","author":"Dubois","year":"2008","journal-title":"Brain."},{"key":"B37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jpeds.2018.08.076","article-title":"Effects of prone sleeping on cerebral oxygenation in preterm infants","volume":"204","author":"Shepherd","year":"2019","journal-title":"J Pediatr"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:15:01Z","timestamp":1590556501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":37,"alternative-id":["10.3389\/fped.2020.00268"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00268","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"article-number":"268"}}