{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T10:36:21Z","timestamp":1767522981015,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313836"],"award-info":[{"award-number":["2016A030313836"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201510010287","201510010159","201607010011"],"award-info":[{"award-number":["201510010287","201510010159","201607010011"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00338","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T04:45:15Z","timestamp":1592887515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The rs1051931 G&gt;A Polymorphism in the PLA2G7 Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population"],"prefix":"10.3389","volume":"8","author":[{"given":"Xueping","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoliang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Pi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huazhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1161\/01.CIR.0000145143.19711.78","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association","volume":"110","author":"Newburger","year":"2004","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/j.jacc.2015.12.073","article-title":"Kawasaki disease","volume":"67","author":"Newburger","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0140-6736(04)16814-1","article-title":"Kawasaki syndrome","volume":"364","author":"Burns","year":"2004","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1136\/archdischild-2014-307536","article-title":"The epidemiology of Kawasaki disease: a global update","volume":"100","author":"Singh","year":"2015","journal-title":"Arch Dis Child"},{"key":"B5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/1756-185X.13224","article-title":"Diagnosis of Kawasaki disease","volume":"21","author":"Singh","year":"2018","journal-title":"Int J Rheum Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1097\/01.inf.0000183786.70519.fa","article-title":"Kawasaki disease: infection, immunity and genetics","volume":"24","author":"Wang","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1097\/00006454-199812000-00009","article-title":"Intravenous gamma-globulin treatment and retreatment in Kawasaki disease","volume":"17","author":"Burns","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.bbalip.2018.07.006","article-title":"Platelet-activating factor acetylhydrolases: an overview and update","volume":"1864","author":"Kono","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0021-9150(03)00086-8","article-title":"Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe","volume":"168","author":"Abuzeid","year":"2003","journal-title":"Atherosclerosis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1538-7836.2006.01895.x","article-title":"Platelet-activating factor-acetylhydrolase A379V (exon 11) gene polymorphism is an independent and functional risk factor for premature myocardial infarction","volume":"4","author":"Liu","year":"2006","journal-title":"J Thromb Haemost"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.2147\/IDR.S174140","article-title":"The rs1625579 T>G polymorphism in the gene confers a risk of early- onset Kawasaki disease in a southern Chinese population","volume":"11","author":"Che","year":"2018","journal-title":"Infect Drug Resist"},{"key":"B13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature10134","article-title":"Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway","volume":"475","author":"Anthony","year":"2011","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1182\/blood-2012-11-468264","article-title":"Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2-dependent prostaglandin E2 in human dendritic cells","volume":"122","author":"Trinath","year":"2013","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jaci.2010.12.1102","article-title":"Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin","volume":"127","author":"Maddur","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0022-3476(05)80900-X","article-title":"Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood","volume":"120","author":"Finberg","year":"1992","journal-title":"J Pediatr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1056\/NEJMra993360","article-title":"Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin","volume":"345","author":"Kazatchkine","year":"2001","journal-title":"N Engl J Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1128\/CMR.11.3.405","article-title":"Kawasaki syndrome","volume":"11","author":"Rowley","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/1753944710375820","article-title":"Darapladib: an emerging therapy for atherosclerosis","volume":"4","author":"Corson","year":"2010","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.atherosclerosis.2008.10.030","article-title":"Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study","volume":"204","author":"Schnabel","year":"2009","journal-title":"Atherosclerosis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1086\/302901","article-title":"The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma","volume":"66","author":"Kruse","year":"2000","journal-title":"Am J Hum Genet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/hmg\/ddn020","article-title":"Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets","volume":"17","author":"Sutton","year":"2008","journal-title":"Hum Mol Genet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1161\/CIRCULATIONAHA.109.923383","article-title":"PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry","volume":"121","author":"Casas","year":"2010","journal-title":"Circulation"},{"key":"B24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1538-7836.2008.03216.x","article-title":"Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study)","volume":"7","author":"Hoffmann","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B25","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/eurheartj\/ehr372","article-title":"Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies","volume":"33","author":"Grallert","year":"2012","journal-title":"Eur Heart J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2459\/JCM.0000000000000057","article-title":"Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease","volume":"16","author":"Maiolino","year":"2015","journal-title":"J Cardiovasc Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1469-1809.2011.00666.x","article-title":"Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population","volume":"75","author":"Li","year":"2011","journal-title":"Ann Hum Genet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jpeds.2005.03.037","article-title":"A polymorphism in plasma platelet-activating factor acetylhydrolase is involved in resistance to immunoglobulin treatment in Kawasaki disease","volume":"147","author":"Minami","year":"2005","journal-title":"J Pediatr"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00338\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T04:45:17Z","timestamp":1592887517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00338\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":28,"alternative-id":["10.3389\/fped.2020.00338"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00338","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2020,6,23]]},"article-number":"338"}}