{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:51:21Z","timestamp":1792245081426,"version":"4.4.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00350","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T11:17:24Z","timestamp":1595589444000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Perioperative Corticosteroid Therapy in Children Undergoing Cardiac Surgery: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"8","author":[{"given":"Yinan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/cyto.b.10018","article-title":"Immune consequences of pediatric and adult cardiovascular surgery: report of the 7th Leipzig workshop","volume":"54","author":"Tarnok","year":"2003","journal-title":"Cytometry Part B Clin Cytom."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S715","DOI":"10.1016\/S0003-4975(02)04701-X","article-title":"Inflammatory response to cardiopulmonary bypass","volume":"75","author":"Levy","year":"2003","journal-title":"Ann Thorac Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"I86","DOI":"10.1161\/01.CIR.33.4S1.I-86","article-title":"Use of corticosteroids during cardiopulmonary bypass: possible lysosome stabilization","volume":"33","author":"Replogle","year":"1966","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1097\/00000539-199710000-00011","article-title":"The systemic inflammatory response to cardiopulmonary bypass: pathophysiological, therapeutic, and pharmacological considerations","volume":"85","author":"Hall","year":"1997","journal-title":"Anesth Analg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.jtcvs.2016.12.013","article-title":"First nights, the adrenal axis, and steroids","volume":"153","author":"Graham","year":"2017","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/PCC.0000000000000541","article-title":"Intraoperative steroid use and outcomes following the norwood procedure: an analysis of the pediatric heart network's public database","volume":"17","author":"Elhoff","year":"2016","journal-title":"Pediatr Crit Care med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N Engl J Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1056\/NEJMoa032089","article-title":"Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity","volume":"350","author":"Yeh","year":"2004","journal-title":"N Engl J Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/S0003-4975(00)01082-1","article-title":"Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children","volume":"69","author":"Bronicki","year":"2000","journal-title":"Ann Thorac Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00246-002-0118-3","article-title":"Systemic inflammatory response related to cardiopulmonary bypass and its modification by methyl prednisolone: high dose vs. low dose","volume":"23","author":"Varan","year":"2002","journal-title":"Pediatr Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1097\/01.CCM.0000063443.32874.60","article-title":"Dexamethasone reduces postoperative troponin levels in children undergoing cardiopulmonary bypass","volume":"31","author":"Checchia","year":"2003","journal-title":"Crit Care Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1161\/01.CIR.0000070955.55636.25","article-title":"Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression","volume":"107","author":"Schroeder","year":"2003","journal-title":"Circulation."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.athoracsur.2005.04.035","article-title":"Steroid supplementation: a legitimate pharmacotherapy after neonatal open heart surgery","volume":"80","author":"Ando","year":"2005","journal-title":"Ann Thorac Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1525-1594.2007.00423.x","article-title":"Comparative effectiveness of methylprednisolone and zero-balance ultrafiltration on inflammatory response after pediatric cardiopulmonary bypass","volume":"31","author":"Liu","year":"2007","journal-title":"Artif Organs."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jtcvs.2011.04.019","article-title":"Standardized preoperative corticosteroid treatment in neonates undergoing cardiac surgery: results from a randomized trial","volume":"142","author":"Graham","year":"2011","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/2150135112447544","article-title":"The effects of multiple doses of glucocorticoids on the inflammatory response to cardiopulmonary bypass in children","volume":"3","author":"Bronicki","year":"2012","journal-title":"World J Pediatr Congenit Heart Surg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5812\/ircmj.8039","article-title":"Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of IL-6 and IL-10","volume":"15","author":"Abbasi Tashnizi","year":"2013","journal-title":"Iran Red Crescent Med J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1016\/j.athoracsur.2013.02.013","article-title":"Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome","volume":"95","author":"Keski-Nisula","year":"2013","journal-title":"Ann Thorac Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e25500","DOI":"10.5812\/cardiovascmed.25500","article-title":"Single dose corticosteroid therapy after surgical repair of Fallot's tetralogy; a randomized controlled clinical trial","volume":"4","author":"Dalili","year":"2015","journal-title":"Res Cardiovasc Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.athoracsur.2014.08.042","article-title":"Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures","volume":"99","author":"Keski-Nisula","year":"2015","journal-title":"Ann Thorac Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1097\/PCC.0000000000000426","article-title":"Postoperative hydrocortisone infusion reduces the prevalence of low cardiac output syndrome after neonatal cardiopulmonary bypass","volume":"16","author":"Robert","year":"2015","journal-title":"Pediatr Crit Care Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/PCC.0000000000000573","article-title":"The effect of methylprednisolone on plasma concentrations of neutrophil gelatinase-associated lipocalin in pediatric heart surgery","volume":"17","author":"Pesonen","year":"2016","journal-title":"Pediatr Crit Care Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.athoracsur.2017.01.111","article-title":"Stress-Dose corticosteroid vs. placebo in neonatal cardiac operations: a randomized controlled trial","volume":"104","author":"Suominen","year":"2017","journal-title":"Ann Thorac Surg."},{"key":"B24","doi-asserted-by":"publisher","first-page":"13134","DOI":"10.1111\/aas.13134","article-title":"Efficacy of corticosteroids in prevention of acute kidney injury in neonates undergoing cardiac surgery-A randomized controlled trial","volume":"62","author":"Jahnukainen","year":"2018","journal-title":"Acta Anaesthesiol Scand"},{"key":"B25","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jacc.2019.05.060","article-title":"Corticosteroid therapy in neonates undergoing cardiopulmonary bypass: randomized controlled trial","volume":"74","author":"Graham","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B26","unstructured":"Julian HigginsJT\n            JacquelineChandler\n            MirandaCumpston\n            TianjingLi\n            MatthewPage\n            VivianWelch\n          Cochrane Handbook for Systematic Reviews of Interventions."},{"key":"B27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/00000542-200207000-00030","article-title":"The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist","volume":"97","author":"Laffey","year":"2002","journal-title":"Anesthesiology."},{"key":"B28","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1097\/00000542-199010000-00012","article-title":"Hormonal-metabolic stress responses in neonates undergoing cardiac surgery","volume":"73","author":"Anand","year":"1990","journal-title":"Anesthesiology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.jtcvs.2012.06.029","article-title":"An empirically based tool for analyzing morbidity associated with operations for congenital heart disease","volume":"145","author":"Jacobs","year":"2013","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1097\/PCC.0000000000000918","article-title":"Utilizing a collaborative learning model to promote early Extubation following infant heart surgery","volume":"17","author":"Mahle","year":"2016","journal-title":"Pediatr Crit Care Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1161\/CIRCULATIONAHA.110.948737","article-title":"Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the pediatric health information systems database","volume":"122","author":"Pasquali","year":"2010","journal-title":"Circulation."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e385","DOI":"10.1542\/peds.2011-2034","article-title":"Perioperative methylprednisolone and outcome in neonates undergoing heart surgery","volume":"129","author":"Pasquali","year":"2012","journal-title":"Pediatrics."},{"key":"B33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/PCC.0000000000000128","article-title":"Perioperative steroids administration in pediatric cardiac surgery: a meta-analysis of randomized controlled trials*","volume":"15","author":"Scrascia","year":"2014","journal-title":"Pediatr Crit Care Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.athoracsur.2010.11.005","article-title":"Improved outcomes associated with intraoperative steroid use in high-risk pediatric cardiac surgery","volume":"91","author":"Clarizia","year":"2011","journal-title":"Ann Thorac Surg."},{"key":"B35","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1007\/s00134-013-2849-4","article-title":"Peri-operative interventions, but not inflammatory mediators, increase risk of acute kidney injury after cardiac surgery: a prospective cohort study","volume":"39","author":"Morgan","year":"2013","journal-title":"Intensive Care Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1681\/ASN.2014080840","article-title":"Intraoperative high-dose dexamethasone and severe AKI after cardiac surgery","volume":"26","author":"Jacob","year":"2015","journal-title":"J Am Soc Nephrol."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00350\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T11:17:28Z","timestamp":1595589448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00350\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":36,"alternative-id":["10.3389\/fped.2020.00350"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00350","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"article-number":"350"}}