{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:47:05Z","timestamp":1790380025904,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00366","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T05:03:01Z","timestamp":1595912581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Renal Precision Medicine in Neonates and Acute Kidney Injury: How to Convert a Cloud of Creatinine Observations to Support Clinical Decisions"],"prefix":"10.3389","volume":"8","author":[{"given":"Karel","family":"Allegaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"van Donge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van den Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosmas","family":"Sarafidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Levtchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djalila","family":"Mekahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/pr.2016.221","article-title":"Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates","volume":"81","author":"Ward","year":"2017","journal-title":"Pediatr Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1136\/archdischild-2019-317399","article-title":"Development of a neonatal adverse event severity scale through a Delphi consensus approach","volume":"104","author":"Salaets","year":"2019","journal-title":"Arch Dis Child."},{"key":"B3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-94-007-7743-9_1-1","article-title":"Creatinine assays in early infancy: how to aim for a moving target","volume-title":"Biomarkers in Kidney Disease","author":"Allegaert","year":"2015"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1007\/s00467-016-3320-x","article-title":"Assessment of kidney function in preterm infants: lifelong implications","volume":"31","author":"Abitbol","year":"2016","journal-title":"Pediatr Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s00467-017-3852-8","article-title":"Educational review: measurement of GFR in special populations","volume":"33","author":"Filler","year":"2018","journal-title":"Pediatr Nephrol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/S0140-6736(17)30576-7","article-title":"A developmental approach to the prevention of hypertension and kidney disease: a report from the low birth weight and nephron number working group","volume":"390","author":"Luyckx","year":"2017","journal-title":"Lancet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3389\/fphar.2020.00587","article-title":"A physiology-based pharmacokinetic framework to support drug development and dose precision during therapeutic hypothermia in neonates","volume":"11","author":"Smits","year":"2020","journal-title":"Front Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fped.2019.00360","article-title":"Drug disposition and pharmacotherapy in neonatal ECMO: from fragmented data to integrated knowledge","volume":"7","author":"Raffaeli","year":"2019","journal-title":"Front Pediatr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.siny.2016.12.002","article-title":"Renal function in the fetus and the neonate - the creatinine enigma","volume":"22","author":"Kastl","year":"2017","journal-title":"Semin Fetal Neonatal Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1007\/s00467-013-2651-0","article-title":"The interplay between drugs and the kidney in premature neonates","volume":"29","author":"Schreuder","year":"2014","journal-title":"Pediatr Nephrol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1111\/j.1651-2227.1990.tb11404.x","article-title":"Urinary creatinine excretion and estimation of muscle mass in infants of 25-34 weeks gestation","volume":"79","author":"Modi","year":"1990","journal-title":"Acta Paediatr Scand."},{"key":"B12","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.2174\/1381612821666150901110533","article-title":"Development of a Physiologically-based pharmacokinetic model for preterm neonates: evaluation with in vivo data","volume":"21","author":"Claassen","year":"2015","journal-title":"Curr Pharm Des."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1515\/cclm-2013-1035","article-title":"Enzymatic isotope dilution mass spectrometry (IDMS) traceable serum creatinine is preferable over Jaffe in neonates and young infants","volume":"52","author":"Allegaert","year":"2014","journal-title":"Clin Chem Lab Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/jpc.12119","article-title":"Neonatal length inaccuracies in clinical practice and related percentile discrepancies detected by a simple length-board","volume":"49","author":"Wood","year":"2013","journal-title":"J Paediatr Child Health."},{"key":"B15","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00467-019-04257-z","article-title":"Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life","volume":"35","author":"Wilhelm-Bals","year":"2020","journal-title":"Pediatr Nephrol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3109\/14767058.2014.969236","article-title":"Cystatin C in newborns: a promising renal biomarker in search for standardization and validation","volume":"28","author":"Allegaert","year":"2015","journal-title":"J Matern Fetal Neonatal Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00508-006-0555-8","article-title":"Cystatin C versus creatinine as a marker of glomerular filtration rate in the newborn","volume":"118","author":"Treiber","year":"2006","journal-title":"Wien Klin Wochenschr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s00467-014-3029-7","article-title":"A new serum cystatin formula for estimating glomerular filtration rat in newborns","volume":"30","author":"Treiber","year":"2015","journal-title":"Pediatr Nephrol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/1744-9987.12054","article-title":"Serum cystatin-C as marker of acute kidney injury in the newborn after perinatal hypoxia\/asphyxia","volume":"18","author":"Treiber","year":"2014","journal-title":"Ther Apher Dial."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.4103\/1319-2442.220881","article-title":"Serum cystatin C levels in healthy Nigerian neonates: is there a need for normative values in Nigerian babies?","volume":"28","author":"Madise-Wobo","year":"2017","journal-title":"Saudi J Kidney Dis Transpl."},{"key":"B21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/147323000303100310","article-title":"Reference values of umbilical cord and third-day cystatin C levels for determining glomerular filtration rates in newborns","volume":"31","author":"Bahar","year":"2003","journal-title":"J Int Med Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1590\/S1807-59322011000200006","article-title":"Longitudinal study of Cystatin C in healthy term newborns","volume":"66","author":"Novo","year":"2011","journal-title":"Clinics (S\u00e3o Paulo)."},{"key":"B23","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1373\/clinchem.2016.264325","article-title":"Multicenter evaluation of Cystatin C measurement after assay standardization","volume":"63","author":"Bargnoux","year":"2017","journal-title":"Clin Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pedneo.2015.08.006","article-title":"Decreased Cystatin C-estimated glomerular filtration rate is correlated with prolonged hospital stay in transient tachypnea of newborn infants","volume":"57","author":"Kim","year":"2016","journal-title":"Pediatr Neonatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/00365513.2018.1472803","article-title":"Serum Cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome","volume":"78","author":"El-Gammacy","year":"2018","journal-title":"Scand J Clin Lab Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00467-005-2075-6","article-title":"Influence of commonly used drugs on the accuracy of cystatin C-derived glomerular filtration rate","volume":"21","author":"Foster","year":"2006","journal-title":"Pediatr Nephrol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/MOP.0b013e32834f62d5","article-title":"Update on acute kidney injury in the neonate","volume":"24","author":"Jetton","year":"2012","journal-title":"Curr Opin Pediatr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fped.2016.00068","article-title":"Assessment of worldwide acute kidney injury epidemiology in neonates: design of a retrospective cohort study","volume":"19","author":"Jetton","year":"2016","journal-title":"Front Pediatr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S2352-4642(17)30069-X","article-title":"Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study","volume":"1","author":"Jetton","year":"2017","journal-title":"Lancet Child Adolesc Health."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1542\/peds.2014-3819","article-title":"Neonatal acute kidney injury","volume":"136","author":"Selewski","year":"2015","journal-title":"Pediatrics."},{"key":"B31","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/pr.2017.136","article-title":"Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop","volume":"82","author":"Zappitelli","year":"2017","journal-title":"Pediatr Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1055\/s-0039-3400311","article-title":"Acute kidney injury and bronchopulmonary dysplasia in premature neonates born less than 32 weeks' gestation","volume":"37","author":"Starr","year":"2020","journal-title":"Am J Perinatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e180322","DOI":"10.1001\/jamapediatrics.2018.0322","article-title":"Association between early caffeine citrate administration and risk of acute kidney injury in preterm neonates: results from the AWAKEN study","volume":"172","author":"Harer","year":"2018","journal-title":"JAMA Pediatr"},{"key":"B34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41390-018-0255-x","article-title":"Late onset neonatal acute kidney injury: results from the AWAKEN study","volume":"85","author":"Charlton","year":"2019","journal-title":"Pediatr Res."},{"key":"B35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1542\/peds.83.1.116","article-title":"Urine output measurement in premature infants","volume":"83","author":"Cooke","year":"1989","journal-title":"Pediatrics."},{"key":"B36","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41390-019-0579-1","article-title":"The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group","volume":"87","author":"Selewski","year":"2020","journal-title":"Pediatr Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.3109\/14767058.2012.657277","article-title":"Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method","volume":"25","author":"Allegaert","year":"2012","journal-title":"J Matern Fetal Neonatal Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijpharm.2012.03.035","article-title":"Drug disposition and clinical practice in neonates: cross talk between developmental physiology and pharmacology","volume":"452","author":"Smits","year":"2013","journal-title":"Int J Pharm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s00467-011-1883-0","article-title":"Postnatal trends in creatinemia and its covariates in extremely low birth weight (ELBW) neonates","volume":"26","author":"George","year":"2011","journal-title":"Pediatr Nephrol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1007\/s11095-013-1197-y","article-title":"A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates","volume":"31","author":"De Cock","year":"2014","journal-title":"Pharm Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000079618","article-title":"Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life","volume":"86","author":"Allegaert","year":"2004","journal-title":"Biol Neonate."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1111\/apa.12041","article-title":"Reference values of serum cystatin C in very low-birthweight premature infants","volume":"102","author":"Demirel","year":"2013","journal-title":"Acta Paediatr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e000685","DOI":"10.1136\/bmjpo-2020-000685","article-title":"Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy: a literature review","volume":"4","author":"Lutz","year":"2020","journal-title":"BMJ Pediatr Open"},{"key":"B44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3109\/14767058.2013.818646","article-title":"Postasphyxial renal injury in newborns as a prognostic factor of neurological outcome","volume":"27","author":"Hadzimuratovic","year":"2014","journal-title":"J Matern Fetal Neonatal Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00467-019-04406-4","article-title":"Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy","volume":"35","author":"Cavallin","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1179\/146532811X12925735813922","article-title":"Evaluation of glomerular and tubular renal function in neonates with birth asphyxia","volume":"31","author":"Kaur","year":"2011","journal-title":"Ann Trop Paediatr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jpeds.2012.10.002","article-title":"Acute kidney injury in asphyxiated newborns treated with therapeutic hypothermia","volume":"162","author":"Selewski","year":"2013","journal-title":"J Pediatr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00467-018-4068-2","article-title":"Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database","volume":"34","author":"Kirkley","year":"2019","journal-title":"Pediatr Nephrol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"CD003311","DOI":"10.1002\/14651858.CD003311.pub3","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"31","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2017.0046","article-title":"Complications during therapeutic hypothermia after perinatal asphyxia: a comparison with trial data","author":"Diederen","year":"2018","journal-title":"Ther Hypothermia Temp Manag."},{"key":"B51","first-page":"928","article-title":"Renal failure in asphyxiated neonates","volume":"42","author":"Gupta","year":"2005","journal-title":"Indian Pediatr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1007\/s00467-012-2162-4","article-title":"Serum and urine acute kidney injury biomarkers in asphyxiated neonates","volume":"27","author":"Sarafidis","year":"2012","journal-title":"Pediatr Nephrol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3892\/etm.2017.4107","article-title":"Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants","volume":"13","author":"Song","year":"2017","journal-title":"Exp Ther Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4103\/jrms.JRMS_112_18","article-title":"Is neutrophil gelatinase-associated lipocalin a gooddiagnostic marker for renal injury in asphyxiated preterm infants?","volume":"23","author":"Pan","year":"2018","journal-title":"J Res Med Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e22070","DOI":"10.1002\/jcla.22070","article-title":"Change of cystatin C values in preterm infants with asphyxia-From two centers of China","volume":"31","author":"Yang","year":"2017","journal-title":"J Clin Lab Anal."},{"key":"B56","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/pr.2013.230","article-title":"Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia","volume":"75","author":"Sarkar","year":"2014","journal-title":"Pediatr Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.siny.2016.09.002","article-title":"Pharmacological management of acute kidney injury and chronic kidney disease in neonates","volume":"22","author":"Jetton","year":"2017","journal-title":"Semin Fetal Neonatal Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1673722","article-title":"Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis","author":"Bellos","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e01282","DOI":"10.1128\/AAC.01282-17","article-title":"Amikacin pharmacokinetics to optimize dosing in neonates with perinatal asphyxia treated with hypothermia","volume":"61","author":"Cristea","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"key":"B60","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jpeds.2019.08.046","article-title":"Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action): reduction of nephrotoxic medication-associated acute kidney injury in the neonatal intensive care unit","volume":"215","author":"Stoops","year":"2019","journal-title":"J Pediatr."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000664","article-title":"Acute kidney injury guidelines are associated with improved recognition and follow-up for neonatal patients","author":"Vincent","year":"2019","journal-title":"Adv Neonatal Care"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3109\/14767058.2013.860522","article-title":"Nephrotoxic medication exposure in very low birth weight infants","volume":"27","author":"Rhone","year":"2014","journal-title":"J Matern Fetal Neonatal Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1159\/000502715","article-title":"Extremely low birth weight predisposes to impaired renal health: a pooled analysis","volume":"44","author":"Gilarska","year":"2019","journal-title":"Kidney Blood Press Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"E2144","DOI":"10.3390\/ijerph17062144","article-title":"Glomerular filtration rate in former extreme low birth weight infants over the full pediatric age range: a pooled analysis","volume":"17","author":"Goetschalckx","year":"2020","journal-title":"Int J Environ Res Public Health."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00366\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T19:53:08Z","timestamp":1667591588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00366\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":64,"alternative-id":["10.3389\/fped.2020.00366"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00366","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"article-number":"366"}}