{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:59:43Z","timestamp":1790492383460,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG05239"],"award-info":[{"award-number":["AG05239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI091501"],"award-info":[{"award-number":["AI091501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI116198"],"award-info":[{"award-number":["AI116198"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL125054"],"award-info":[{"award-number":["HL125054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH107333"],"award-info":[{"award-number":["MH107333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH108458"],"award-info":[{"award-number":["MH108458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OD010568"],"award-info":[{"award-number":["OD010568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OD011104"],"award-info":[{"award-number":["OD011104"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OD024282"],"award-info":[{"award-number":["OD024282"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00388","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T05:02:06Z","timestamp":1594875726000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and Immunological Metrics During Pediatric Rhesus Macaque Development"],"prefix":"10.3389","volume":"8","author":[{"given":"Kristen M.","family":"Merino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Slisarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine P.","family":"Falkenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret H.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf P.","family":"Bohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ardeshir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo J.","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev Clin Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1159\/000323934","article-title":"Natural killer cell responses to infections in early life","volume":"3","author":"Guilmot Hermann","year":"2011","journal-title":"J Innate Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/eji.200838391","article-title":"Phenotype and function of neonatal DC","volume":"39","author":"Willems","year":"2009","journal-title":"Eur J Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/mi.2016.81","article-title":"Neonatal mucosal immunology","volume":"10","author":"Torow","year":"2017","journal-title":"Mucosal Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3389\/fimmu.2014.00393","article-title":"Unbalanced Neonatal CD4(+) T-Cell Immunity","volume":"5","author":"Debock","year":"2014","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/imr.12190","article-title":"Maturation of the enteric mucosal innate immune system during the postnatal period","volume":"260","author":"Fulde","year":"2014","journal-title":"Immunol Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nri.2016.19","article-title":"Paediatric HIV infection: the potential for cure","volume":"16","author":"Goulder","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fimmu.2016.00310","article-title":"Linking susceptibility to infectious diseases to immune system abnormalities among HIV-exposed uninfected infants","volume":"7","author":"Ruck","year":"2016","journal-title":"Front Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/imr.12074","article-title":"Immunology of pediatric HIV infection","volume":"254","author":"Tobin","year":"2013","journal-title":"Immunol Rev."},{"key":"B10","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/jama.1996.03530320030030","article-title":"Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. The French Pediatric HIV Infection Study Group","volume":"275","author":"Mayaux","year":"1996","journal-title":"JAMA"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/S0140-6736(04)17140-7","article-title":"Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis","volume":"364","author":"Newell","year":"2004","journal-title":"Lancet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/aji.12083","article-title":"Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease","volume":"69","author":"Burt","year":"2013","journal-title":"Am J Reprod Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.3390\/ijms19072099","article-title":"B regulatory cells: players in pregnancy and early life","volume":"19","author":"Esteve-Sol\u00e9 Luo","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"7725","DOI":"10.1038\/ncomms8725","article-title":"Active suppression of intestinal CD4(+)TCRalphabeta(+) T-lymphocyte maturation during the postnatal period","volume":"6","author":"Torow","year":"2015","journal-title":"Nat Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nm.4008","article-title":"Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues","volume":"22","author":"Thome","year":"2016","journal-title":"Nat Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/cei.13008","article-title":"Significant augmentation of regulatory T cell numbers occurs during the early neonatal period","volume":"190","author":"Hayakawa","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.cell.2018.06.045","article-title":"Stereotypic immune system development in newborn children","volume":"174","author":"Olin Henckel","year":"2018","journal-title":"Cell."},{"key":"B18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41590-018-0084-4","article-title":"Of mice, men and immunity: a case for evolutionary systems biology","volume":"19","author":"Ernst","year":"2018","journal-title":"Nat Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.4049\/jimmunol.1700453","article-title":"Of Mice, dirty mice, and men: using mice to understand human immunology","volume":"199","author":"Masopust","year":"2017","journal-title":"J Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/jp.2011.60","article-title":"Umbilical cord blood as a replacement source for admission complete blood count in premature infants","volume":"32","author":"Carroll","year":"2012","journal-title":"J Perinatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000083946","article-title":"Potential substitution of cord blood for infant blood in the neonatal sepsis evaluation","volume":"88","author":"Hansen","year":"2005","journal-title":"Biol Neonate."},{"key":"B22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000491993","article-title":"Can fetal umbilical venous blood be a reliable source for admission complete blood count and culture in NICU patients?","volume":"115","author":"Greer","year":"2018","journal-title":"Neonatology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"178","DOI":"10.15406\/htij.2016.03.00067","article-title":"Hematological differences in newborn and aging: a review study","volume":"3","author":"Ayodele","year":"2016","journal-title":"Hematol Transfus Int J."},{"key":"B24","first-page":"1","article-title":"Committee for the update of the guide for the care and use of laboratory animals","volume-title":"The National Academies Collection: Guide for the Care and Use of Laboratory Animals","author":"NR","year":"2011"},{"key":"B25","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/MPG.0b013e31827e1f07","article-title":"Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism","volume":"56","author":"O'Sullivan He","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2333794X15608716","DOI":"10.1177\/2333794X15608716","article-title":"Comparison among commonly available infant formula milks in the iraqi market","volume":"2","author":"Mikhael","year":"2015","journal-title":"Glob Pediatr Health"},{"key":"B27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1742-4933-9-25","article-title":"Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)","volume":"9","author":"Didier","year":"2012","journal-title":"Immun Ageing."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/157016209787048528","article-title":"The rhesus macaque pediatric SIV infection model - a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategies","volume":"7","author":"Abel","year":"2009","journal-title":"Curr HIV Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0892-0362(00)00073-8","article-title":"Methods for studying nonhuman primates in neurobehavioral toxicology and teratology","volume":"22","author":"Burbacher","year":"2000","journal-title":"Neurotoxicol Teratol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/ar.22943","article-title":"Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta)","volume":"297","author":"Batchelder","year":"2014","journal-title":"Anat Rec (Hoboken)."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.4049\/jimmunol.1301713","article-title":"Psychological stress in children may alter the immune response","volume":"192","author":"Carlsson","year":"2014","journal-title":"J Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e0200236","DOI":"10.1371\/journal.pone.0200236","article-title":"Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study","volume":"13","author":"Lur\u00e0","year":"2018","journal-title":"PLoS ONE."},{"key":"B33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000457920","article-title":"Breastfeeding, childhood asthma, allergic disease","volume":"70","author":"Oddy","year":"2017","journal-title":"Ann Nutr Metab"},{"key":"B34","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1159\/000487618","article-title":"Perinatal origins of adult disease","volume":"113","author":"Simeoni","year":"2018","journal-title":"Neonatology."},{"key":"B35","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cll.2014.10.010","article-title":"Hematology analyzers: special considerations for pediatric patients","volume":"35","author":"Wong","year":"2015","journal-title":"Clin Lab Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.semperi.2008.10.010","article-title":"The CBC: reference ranges for neonates","volume":"33","author":"Christensen","year":"2009","journal-title":"Semin Perinatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.clp.2015.04.005","article-title":"Reference intervals in neonatal hematology","volume":"42","author":"Henry","year":"2015","journal-title":"Clin Perinatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.3945\/jn.114.197558","article-title":"Bovine osteopontin modifies the intestinal transcriptome of formula-fed infant rhesus monkeys to be more similar to those that were breastfed","volume":"144","author":"Donovan","year":"2014","journal-title":"J Nutr."},{"key":"B39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/978-0-387-25640-5_26","article-title":"Hematology serum chemistry reference values for rhesus macaque (Macaca mulatta) infants","volume-title":"Nursery Rearing of Nonhuman Primates in the 21st Century","author":"Capitanio","year":"2006"},{"key":"B40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/15287399409531863","article-title":"Normative hematologic and serum biochemical values for adult and infant rhesus monkeys (Macaca mulatta) in a controlled laboratory environment","volume":"42","author":"Fernie","year":"1994","journal-title":"J Toxicol Environ Health."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e000166","DOI":"10.1136\/vetreco-2015-000166","article-title":"Age-associated and breed-associated variations in haematological and biochemical variables in young labrador retriever and miniature schnauzer dogs","volume":"3","author":"Brenten","year":"2016","journal-title":"Vet Rec Open."},{"key":"B42","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1939-165X.2012.00415.x","article-title":"Age-related changes in biochemical and hematologic variables in Borzoi and Beagle puppies from birth to 8 weeks","volume":"41","author":"Rosset","year":"2012","journal-title":"Vet Clin Pathol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1373\/clinchem.2015.240515","article-title":"Biochemical marker reference values across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey","volume":"61","author":"Adeli","year":"2015","journal-title":"Clin Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/clinchem\/30.3.407","article-title":"Normal reference-intervals for 20 biochemical variables in healthy infants, children, and adolescents","volume":"30","author":"Gomez","year":"1984","journal-title":"Clin Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jcma.2011.09.007","article-title":"Differences in serum biochemistry between breast-fed and formula-fed infants","volume":"74","author":"Wu","year":"2011","journal-title":"J Chin Med Assoc."},{"key":"B46","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12917-017-0946-2","article-title":"The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation","volume":"13","author":"Ventrella","year":"2017","journal-title":"BMC Vet Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/2049-1891-5-5","article-title":"Hematologic and biochemical reference intervals for specific pathogen free 6-week-old Hampshire-Yorkshire crossbred pigs","volume":"5","author":"Cooper","year":"2014","journal-title":"J Anim Sci Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.imlet.2016.03.009","article-title":"Distinct mechanisms of the newborn innate immunity","volume":"173","author":"Kumar","year":"2016","journal-title":"Immunol Lett."},{"key":"B49","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.exphem.2013.01.009","article-title":"The migration of hematopoietic progenitors from the fetal liver to the fetal bone marrow: lessons learned and possible clinical applications","volume":"41","author":"Ciriza","year":"2013","journal-title":"Exp Hematol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/clin.1997.4439","article-title":"Lymphocyte phenotyping in infants: maturation of lymphocyte subpopulations and the effects of HIV infection","volume":"85","author":"Rich","year":"1997","journal-title":"Clin Immunol Immunopathol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jaci.2014.06.030","article-title":"Control lymphocyte subsets: can one country's values serve for another's?","volume":"134","author":"Mandala","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/cyto.b.21728","article-title":"Extended immunophenotyping reference values in a healthy pediatric population","volume":"96","author":"Garcia-Prat","year":"2018","journal-title":"Cytometry B Clin Cytom."},{"key":"B53","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/sji.12183","article-title":"Phenotypic differences in leucocyte populations among healthy preterm and full-term newborns","volume":"80","author":"Quinello","year":"2014","journal-title":"Scand J Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/cmi.2009.55","article-title":"The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques","volume":"6","author":"Xia","year":"2009","journal-title":"Cell Mol Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3402\/pba.v2i0.18052","article-title":"Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta)","volume":"2","author":"Asquith Haberthur","year":"2012","journal-title":"Pathobiol Aging Age Relat Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12979-015-0030-3","article-title":"The interplay between immune maturation, age, chronic viral infection and environment","volume":"12","author":"Oxford","year":"2015","journal-title":"Immun Ageing."},{"key":"B57","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1034\/j.1600-0609.2000.065004245.x","article-title":"Characterization of lymphocyte subsets in rhesus macaques during the first year of life","volume":"65","author":"DeMaria","year":"2000","journal-title":"Eur J Haematol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0006-3223(99)00238-3","article-title":"Early social deprivation in nonhuman primates: long-term effects on survival and cell-mediated immunity","volume":"47","author":"Lewis","year":"2000","journal-title":"Biol Psychiatry."},{"key":"B59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1006\/brbi.1995.1004","article-title":"Effects of early rearing environment on immune responses of infant rhesus monkeys","volume":"9","author":"Lubach","year":"1995","journal-title":"Brain Behav Immun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2007.10.049","article-title":"Cytokines and anti-cytokines as therapeutics\u2013an update","volume":"579","author":"Tayal","year":"2008","journal-title":"Eur J Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3389\/fimmu.2014.00457","article-title":"Soluble mediators regulating immunity in early life","volume":"5","author":"Pettengill","year":"2014","journal-title":"Front Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1186\/1756-0500-6-547","article-title":"Levels of 25 cytokines in the first seven days of life in newborn infants","volume":"6","author":"Lusyati","year":"2013","journal-title":"BMC Res Notes."},{"key":"B63","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S1043-4666(02)00498-2","article-title":"Modulation of pro- and anti-inflammatory cytokine production in very preterm infants","volume":"21","author":"Dembinski","year":"2003","journal-title":"Cytokine."},{"key":"B64","doi-asserted-by":"publisher","first-page":"8973","DOI":"10.1038\/s41598-018-27190-x","article-title":"A System of cytokines encapsulated in extracellular vesicles","volume":"8","author":"Fitzgerald","year":"2018","journal-title":"Sci Rep."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00388\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T05:02:11Z","timestamp":1594875731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00388\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":64,"alternative-id":["10.3389\/fped.2020.00388"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00388","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"article-number":"388"}}