{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:23:26Z","timestamp":1776731006020,"version":"3.51.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00437","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T05:43:42Z","timestamp":1596519822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis"],"prefix":"10.3389","volume":"8","author":[{"given":"Gina","family":"Fong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhita","family":"Gayen nee' Betal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Favara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna S. Y.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankar","family":"Addya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Greenspan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair H.","family":"Aghai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/j.ajog.2015.08.040","article-title":"Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance","volume":"213","author":"Kim","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/14767058.2010.482622","article-title":"The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor","volume":"24","author":"Mi Lee","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3109\/14767058.2012.722724","article-title":"Histologic chorioamnionitis at term: implications for the progress of labor and neonatal wellbeing","volume":"26","author":"Torricelli","year":"2013","journal-title":"J Mater Fetal Neonatal Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.dhjo.2008.08.001","article-title":"Prevalence of cerebral palsy: autism and developmental disabilities monitoring network, three sites, United States, 2004","volume":"2","author":"Arneson","year":"2009","journal-title":"Disabil Health J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1001\/archpediatrics.2008.506","article-title":"Health care use and health and functional impact of developmental disabilities among US children, 1997-2005","volume":"163","author":"Boulet","year":"2009","journal-title":"Arch Pediatr Adolesc Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3109\/14767058.2010.509931","article-title":"Fetal and early postnatal life roots of asthma","volume":"23","author":"De Luca","year":"2010","journal-title":"J Mater-Fetal Neonatal Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/archpediatrics.2009.238","article-title":"Effect of chorioamnionitis on early childhood asthma","volume":"164","author":"Getahun","year":"2010","journal-title":"Arch Pediatr Adolesc Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/AOG.0b013e3181e90046","article-title":"Chorioamnionitis and cerebral palsy: a meta-analysis","volume":"116","author":"Shatrov","year":"2010","journal-title":"Obstet Gynecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1001\/jamapediatrics.2013.4248","article-title":"Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates","volume":"168","author":"Pappas","year":"2014","journal-title":"JAMA Pediatr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ejpn.2013.12.005","article-title":"Chorioamnionitis and cerebral palsy: lessons from a patient registry","volume":"18","author":"Shevell","year":"2014","journal-title":"Eur J Paediatr Neurol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-2354","article-title":"Changing trends in asthma prevalence among children","volume":"137","author":"Akinbami","year":"2016","journal-title":"Pediatrics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1513\/AnnalsATS.201507-411OC","article-title":"Pulmonary morbidity in infancy after exposure to chorioamnionitis in late preterm infants","volume":"13","author":"McDowell","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e20163781","DOI":"10.1542\/peds.2016-3781","article-title":"Chorioamnionitis in the development of cerebral palsy: a meta-analysis and systematic review","volume":"139","author":"Shi","year":"2017","journal-title":"Pediatrics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J Internal Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.reprotox.2006.08.012","article-title":"Epigenetic gene regulation: Linking early developmental environment to adult disease","volume":"23","author":"Dolinoy","year":"2007","journal-title":"Reprod Toxicol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ajog.2013.02.006","article-title":"DNA methylation at imprint regulatory regions in preterm birth and infection","volume":"208","author":"Liu","year":"2013","journal-title":"Am J Obstet Gynecol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13072-018-0234-9","article-title":"DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births","volume":"11","author":"Konwar","year":"2018","journal-title":"Epigene Chromatin"},{"key":"B19","doi-asserted-by":"publisher","first-page":"5862","DOI":"10.1038\/s41598-019-42205-x","article-title":"Histological chorioamnionitis induces differential gene expression in human cord blood mononuclear leukocytes from term neonates","volume":"9","author":"Gayen Nee' Betal","year":"2019","journal-title":"Sci Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10024-003-7070-y","article-title":"Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns","volume":"6","author":"Redline","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/gb-2012-13-6-r44","article-title":"SWAN: Subset-quantile within array normalization for illumina infinium humanmethylation450 beadchips","volume":"13","author":"Maksimovic","year":"2012","journal-title":"Genome Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1165\/rcmb.2011-0421OC","article-title":"AGR2 is induced in asthma and promotes allergen-induced mucin overproduction","volume":"47","author":"Schroeder","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"G374","DOI":"10.1152\/ajpgi.00386.2016","article-title":"Nitric oxide regulates homeoprotein OTX1 and OTX2 expression in the rat myenteric plexus after intestinal ischemia-reperfusion injury","volume":"312","author":"Filpa","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0169338","DOI":"10.1371\/journal.pone.0169338","article-title":"Differential HDAC1 and 2 recruitment by members of the MIER family","volume":"12","author":"Derwish","year":"2017","journal-title":"PLoS ONE"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1080\/15384101.2016.1156267","article-title":"T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4","volume":"15","author":"Liao","year":"2016","journal-title":"Cell Cycle"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1016\/j.bbadis.2017.08.031","article-title":"Wnt\/beta-catenin signaling links embryonic lung development and asthmatic airway remodeling","volume":"1863","author":"Hussain","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1038\/emboj.2010.154","article-title":"AGAP1\/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release","volume":"29","author":"Bendor","year":"2010","journal-title":"Embo J"},{"key":"B30","first-page":"422","article-title":"Brain development is a multi-level regulated process\u2013the case of the OTX2 gene","volume":"9","author":"Gat-Yablonski","year":"2011","journal-title":"Pediatr Endocrinol Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s00011-017-1077-8","article-title":"Slc11a1 (Nramp-1) gene modulates immune-inflammation genes in macrophages during pristane-induced arthritis in mice","volume":"66","author":"Correa","year":"2017","journal-title":"Inflamm Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.4049\/jimmunol.0802002","article-title":"Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery","volume":"182","author":"Han","year":"2009","journal-title":"J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12974-015-0432-3","article-title":"Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis","volume":"12","author":"Makar","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/cr.2014.10","article-title":"VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex","volume":"24","author":"Zhang","year":"2014","journal-title":"Cell Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e99506","DOI":"10.15252\/embj.201899506","article-title":"Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion","volume":"38","author":"Wu","year":"2019","journal-title":"Embo J"},{"key":"B36","first-page":"607","article-title":"[Cyclin D1 and its association with airway remodeling in a murine model of asthma]","volume":"29","author":"Ge","year":"2006","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi."},{"key":"B37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/01902140903290022","article-title":"Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha","volume":"36","author":"Du","year":"2010","journal-title":"Exp Lung Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e002087","DOI":"10.1161\/CIRCGEN.118.002087","article-title":"Loss-of-function ABCC8 mutations in pulmonary arterial hypertension","volume":"11","author":"Bohnen","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2310\/JIM.0000000000000020","article-title":"Adrenomedullin expression in the developing human fetal lung","volume":"62","author":"Ramos","year":"2014","journal-title":"J Investig Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"103586","DOI":"10.1016\/j.ejmg.2018.11.020","article-title":"A de novo 2q37.2 deletion encompassing AGAP1 and SH3BP4 in a patient with autism and intellectual disability","volume":"62","author":"Pacault","year":"2018","journal-title":"Eur J Med Genet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/acn3.551","article-title":"Genomic analysis identifies masqueraders of full-term cerebral palsy","volume":"5","author":"Takezawa","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.neuron.2013.05.027","article-title":"The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex","volume":"79","author":"Xie","year":"2013","journal-title":"Neuron."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/0883073809338066","article-title":"Fetal inflammatory response and brain injury in the preterm newborn","volume":"24","author":"Malaeb","year":"2009","journal-title":"J Child Neurol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12974-018-1149-x","article-title":"Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus","volume":"15","author":"Gussenhoven","year":"2018","journal-title":"J Neuroinflamm"},{"key":"B45","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13148-017-0335-5","article-title":"DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD","volume":"9","author":"Sundar","year":"2017","journal-title":"Clin Epigenetics"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00437\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T05:43:45Z","timestamp":1596519825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00437\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":45,"alternative-id":["10.3389\/fped.2020.00437"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00437","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"article-number":"437"}}