{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:27:13Z","timestamp":1781900833509,"version":"3.54.5"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.00481","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T15:35:23Z","timestamp":1598024123000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes"],"prefix":"10.3389","volume":"8","author":[{"given":"Hanna","family":"Borysewicz-Sa\u0144czyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Sawicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Wawrusiewicz-Kurylonek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"G\u0142owi\u0144ska-Olszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kad\u0142ubiska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Go\u015bcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Szadkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"\u0141osiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kretowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Bossowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1093\/aje\/kwv292","article-title":"Prediction and prevention of autoimmune disease in the 21st century: a review and preview","volume":"183","author":"Rose","year":"2016","journal-title":"Am J Epidemiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"6219730","DOI":"10.1155\/2016\/6219730","article-title":"Effect of associated autoimmune diseases on type 1 diabetes mellitus incidence and metabolic control in children and adolescents","volume":"2016","author":"Krzewska","year":"2016","journal-title":"Biomed Res Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S417","DOI":"10.1007\/s00259-002-0848-8","article-title":"Autoimmunity in thyroid disease","volume":"29","author":"Collins","year":"2002","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1016\/j.lpm.2012.10.003","article-title":"Pancreatic islet autoimmunity","volume":"41","author":"Boitard","year":"2012","journal-title":"Presse Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jaut.2015.03.006","article-title":"Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes","volume":"60","author":"Tomer","year":"2015","journal-title":"J Autoimmun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1210\/jc.2002-020492","article-title":"The genetics of autoimmune thyroid disease","volume":"87","author":"Vaidya","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3389\/fgene.2018.00535","article-title":"Type 1 diabetes mellitus-associated genetic variants contribute to overlapping immune regulatory networks","volume":"21","author":"Nyaga","year":"2018","journal-title":"Front Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3109\/08916934.2014.910767","article-title":"Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases","volume":"47","author":"Bossowski","year":"2014","journal-title":"Autoimmunity."},{"key":"B9","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1210\/jc.86.2.930","article-title":"Evidence for a major role of heredity in graves' disease: a population-based study of two danish twin cohorts","volume":"86","author":"Brix","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1007\/s00125-009-1427-3","article-title":"Familial association between type 1 diabetes and other autoimmune and related diseases","volume":"52","author":"Hemminki","year":"2009","journal-title":"Diabetologia."},{"key":"B11","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/sj.gene.6363655","article-title":"CTLA-4 in autoimmune diseases \u2013 a general susceptibility gene to autoimmunity?","volume":"1","author":"Kristiansen","year":"2000","journal-title":"Genes Immun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.280.5366.1077","article-title":"Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome","volume":"280","author":"Wang","year":"1998","journal-title":"Science."},{"key":"B14","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.smim.2009.04.004","article-title":"IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity","volume":"21","author":"Wang","year":"2009","journal-title":"Semin Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s12020-019-01859-3","article-title":"Association and gene-gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease","volume":"64","author":"Fathima","year":"2019","journal-title":"Endocrine."},{"key":"B16","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1365-2265.2007.02762.x","article-title":"Association of the interleukin-2 receptor alpha (IL-2R\u03b1)\/CD25 gene region with Graves' disease using a multilocus test and tag SNPs","volume":"66","author":"Brand","year":"2007","journal-title":"Clin Endocrinol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1210\/jc.2007-0173","article-title":"Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to graves' disease susceptibility","volume":"92","author":"Sutherland","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.gene.2012.12.030","article-title":"Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: a meta-analysis","volume":"516","author":"Chen","year":"2013","journal-title":"Gene."},{"key":"B19","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/315669a0","article-title":"Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes","volume":"315","author":"Lowenthal","year":"1985","journal-title":"Nature."},{"key":"B20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/imammb\/dqw021","article-title":"The effects of interleukin-2 on immune response regulation","volume":"35","author":"Waters","year":"2018","journal-title":"Math Med Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1126\/science.1117893","article-title":"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors","volume":"18","author":"Wang","year":"2005","journal-title":"Science."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2007.08.005","article-title":"Interleukin-2 receptor signaling in regulatory T cell development and homeostasis","volume":"30","author":"Burchill","year":"2007","journal-title":"Immunol Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/1074-7613(95)90180-9","article-title":"Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment","volume":"3","author":"Willerford","year":"1995","journal-title":"Immunity."},{"key":"B24","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1210\/jc.2008-1596","article-title":"Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population","volume":"94","author":"Kawasaki","year":"","journal-title":"J Clin Endocrinol Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/1753-0407.12192","article-title":"Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families","volume":"7","author":"Rodriguez","year":"2015","journal-title":"J Diabetes."},{"key":"B26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11892-015-0656-8","article-title":"Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression","volume":"15","author":"Looney","year":"2015","journal-title":"Curr Diab Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"17264","DOI":"10.1073\/pnas.0407639101","article-title":"The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter","volume":"101","author":"Andrejeva","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1371\/journal.pone.0001035","article-title":"Assembly of inflammation-related genes for pathway-focused genetic analysis","volume":"2","author":"Loza","year":"2007","journal-title":"PLoS ONE."},{"key":"B29","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.2337\/diabetes.54.suppl_2.S125","article-title":"Environmental triggers and determinants of type 1 diabetes","volume":"54","author":"Knip","year":"2005","journal-title":"Diabetes"},{"key":"B30","first-page":"39","article-title":"Expression and functional significance of CTLA-4, a negative regulator of T cell activation","volume":"49","author":"Kosmaczewska","year":"2001","journal-title":"Arch Immunol Ther Exp (Warsz)."},{"key":"B31","doi-asserted-by":"publisher","first-page":"542","DOI":"10.2174\/138920211798120772","article-title":"The genetic basis of graves' disease","volume":"12","author":"P\u0142oski","year":"2011","journal-title":"Curr Genomics."},{"key":"B32","doi-asserted-by":"publisher","first-page":"46478","DOI":"10.1074\/jbc.M206894200","article-title":"A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele","volume":"277","author":"Anjos","year":"2002","journal-title":"J Biol Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/hmg\/5.7.1075","article-title":"The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes","volume":"5","author":"Nistic\u00f2","year":"1996","journal-title":"Hum Mol Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1046\/j.1365-2265.1998.00579.x","article-title":"A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients","volume":"49","author":"Kemp","year":"1998","journal-title":"Clin Endocrinol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/ahg.12262","article-title":"Association of CTLA-4 polymorphisms with increased risks of myasthenia gravis","volume":"82","author":"Li","year":"2018","journal-title":"Ann Hum Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/sim.3531","article-title":"Recommended tests for association in 2 x 2 tables","volume":"28","author":"Lydersen","year":"2009","journal-title":"Statist Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Stat Soc."},{"key":"B38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/genetics\/49.1.49","article-title":"The interaction of selection and linkage. I. General considerations; heterotic models","volume":"49","author":"Lewontin","year":"1964","journal-title":"Genetic."},{"key":"B39","unstructured":"R: A Language and Environment for Statistical Computing2012"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods."},{"key":"B41","unstructured":"Genetics: Population Genetics2019"},{"key":"B42","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1086\/429843","article-title":"Localization of a type 1 diabetes locus in the IL2RA \/ CD25 region by use of tag single-nucleotide polymorphisms","volume":"76","author":"Vella","year":"2005","journal-title":"Am J Hum Genet."},{"key":"B43","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/j.1365-3083.2011.02608.x","article-title":"A variant of the Il2ra \/ Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor","volume":"74","author":"Chistiakov","year":"2011","journal-title":"Scand J Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"Stahl","year":"2010","journal-title":"Nat Genet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/art.24187","article-title":"Association of the IL2RA \/ CD25 gene with juvenile idiopathic arthritis","volume":"60","author":"Hinks","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1111\/jcmm.12642","article-title":"Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies","volume":"19","author":"Tang","year":"2015","journal-title":"Cell Mol Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.2337\/db06-1555","article-title":"Toward further mapping of the association between the IL2RA locus and type 1 diabetes","volume":"56","author":"Qu","year":"2007","journal-title":"Diabetes."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/ng2102","article-title":"Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes","volume":"39","author":"Lowe","year":"2007","journal-title":"Nat Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00251-009-0417-4","article-title":"Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset finnish type 1 diabetes subjects","volume":"62","author":"Klinker","year":"2010","journal-title":"Immunogenetics."},{"key":"B50","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1399-0039.2011.01828.x","article-title":"Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the polish population","volume":"79","author":"Fichna","year":"2012","journal-title":"Tissue Antigens."},{"key":"B51","doi-asserted-by":"publisher","first-page":"6957","DOI":"10.1007\/s11033-013-2815-9","article-title":"Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2","volume":"40","author":"Fichna","year":"2013","journal-title":"Mol Biol Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/08916934.2018.1486824","article-title":"Analysis of chosen polymorphisms rs2476601 a\/G - PTPN22, rs1990760 C\/T - IFIH1, rs179247 a\/G - TSHR in pathogenesis of autoimmune thyroid diseases in children","volume":"51","author":"Rydzewska","year":"2018","journal-title":"Autoimmunity."},{"key":"B53","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/ng1800","article-title":"A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region","volume":"38","author":"Smyth","year":"2006","journal-title":"Nat Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1038\/gene.2009.96","article-title":"The type I diabetes genetics consortium. analysis of 19 genes for association with type I diabetes in the type I diabetes genetics consortium families","volume":"10","author":"Howson","year":"2009","journal-title":"Genes Immun"},{"key":"B55","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/hmg\/ddn342","article-title":"IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells","volume":"15","author":"Liu","year":"2009","journal-title":"Hum Mol Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s00125-009-1561-y","article-title":"The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations","volume":"53","author":"Jermendy","year":"2010","journal-title":"Diabetologia."},{"key":"B57","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3109\/08916934.2013.796937","article-title":"Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis","volume":"46","author":"Cen","year":"2013","journal-title":"Autoimmunity."},{"key":"B58","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.diabres.2014.11.008","article-title":"Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes","volume":"107","author":"Zurawek","year":"2015","journal-title":"Diabetes Res Clin Pract."},{"key":"B59","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/pedi.12569","article-title":"Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus","volume":"19","author":"Jermendy","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"B60","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/1471-2350-10-126","article-title":"The rs1990760 polymorphism within the IFIH1 locus is not associated with graves' disease, Hashimoto's thyroiditis and Addison's disease","volume":"10","author":"Penna-Martinez","year":"2009","journal-title":"BMC Med Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s12020-007-9024-z","article-title":"The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to graves' disease in Chinese population","volume":"32","author":"Zhao","year":"2007","journal-title":"Endocrine."},{"key":"B62","doi-asserted-by":"publisher","first-page":"BSR20190309","DOI":"10.1042\/BSR20190309","article-title":"Associations between cytotoxic t-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3892\/br.2016.813","article-title":"Association of CTLA-4 gene polymorphisms\u2212318C\/T and +49A\/G and Hashimoto's thyroidits in Zahedan, Iran","volume":"6","author":"Narooie-Nejad","year":"2017","journal-title":"Biomed Rep."},{"key":"B64","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10875-012-9721-0","article-title":"Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies","volume":"32","author":"Inoue","year":"2012","journal-title":"J Clin Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000129676","article-title":"Graves' disease in Brazilian children and adults: lack of genetic association with CTLA-4 +49A>G polymorphism","volume":"70","author":"Namo Cury","year":"2008","journal-title":"Horm Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"110614","DOI":"10.18632\/oncotarget.22702","article-title":"Association between rs3087243 and rs231775 polymorphism within the cytotoxic T-lymphocyte antigen 4 gene and graves' disease: a case\/control study combined with meta-analyses","volume":"8","author":"Tu","year":"2017","journal-title":"Oncotarget."},{"key":"B67","doi-asserted-by":"publisher","first-page":"0154394","DOI":"10.1371\/journal.pone.0154394","article-title":"Association of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene polymorphisms with autoimmune thyroid disease in children and adults: case-control study","volume":"11","author":"Ting","year":"2016","journal-title":"PLoS ONE."},{"key":"B68","doi-asserted-by":"publisher","first-page":"0149441","DOI":"10.1371\/journal.pone.0149441","article-title":"Association of cytotoxic T-lymphocyte antigen 4 (CTLA4) and thyroglobulin (TG) genetic variants with autoimmune hypothyroidism","volume":"11","author":"Patel","year":"2016","journal-title":"PLoS ONE."},{"key":"B69","doi-asserted-by":"publisher","first-page":"641","DOI":"10.18388\/abp.2013_2034","article-title":"CTLA-4 polymorphisms (+49 A\/G and\u2212318 C\/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in polish children \u2014 preliminary study","volume":"60","author":"Pastuszak-Lewandoska","year":"2013","journal-title":"Acta Biochimica Polonica."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00481\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:48:28Z","timestamp":1616978908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fped.2020.00481\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":69,"alternative-id":["10.3389\/fped.2020.00481"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.00481","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"article-number":"481"}}