{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:59:32Z","timestamp":1768985972197,"version":"3.49.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> We postulate a relationship between a transcutaneous hepatic NIRS measurement and a directly obtained hepatic vein saturation. If true, hepatic NIRS monitoring (in conjunction with the current dual-site cerebral-renal NIRS paradigm) might increase the sensitivity for detecting shock since regional oxygen delivery changes in the splanchnic circulation before the kidney or brain. We explored a reliable technique for hepatic NIRS monitoring as a prelude to rigorously testing this hypothesis. This proof-of-concept study aimed to validate hepatic NIRS monitoring by comparing hepatic NIRS measurements to direct hepatic vein samples obtained during cardiac catheterization.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> IRB-approved prospective pilot study of hepatic NIRS monitoring involving 10 patients without liver disease who were already undergoing elective cardiac catheterization. We placed a NIRS monitor on the skin overlying liver during catheterization. Direct measurement of hepatic vein oxygen saturation during the case compared with simultaneous hepatic NIRS measurement.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was no correlation between the Hepatic NIRS values and the directly measured hepatic vein saturation (<jats:italic>R<\/jats:italic> = \u22120.035; <jats:italic>P<\/jats:italic> = 0.9238). However, the Hepatic NIRS values correlated with the cardiac output (<jats:italic>R<\/jats:italic> = 0.808; <jats:italic>P<\/jats:italic> = 0.0047), the systolic arterial blood pressure (<jats:italic>R<\/jats:italic> = 0.739; <jats:italic>P<\/jats:italic> = 0.0146), and the diastolic arterial blood pressure (<jats:italic>R<\/jats:italic> = 0.7548; <jats:italic>P<\/jats:italic> = 0.0116).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Using the technique described, hepatic NIRS does not correlate well with the hepatic vein saturation. Further optimization of the technique might provide a better measurement. Hepatic NIRS does correlate with cardiac output and thus may still provide a valuable additional piece of hemodynamic information when combined with other non-invasive monitoring.<\/jats:p>","DOI":"10.3389\/fped.2020.563483","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T08:28:03Z","timestamp":1605774483000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["An Elusive Prize: Transcutaneous Near InfraRed Spectroscopy (NIRS) Monitoring of the Liver"],"prefix":"10.3389","volume":"8","author":[{"suffix":"Jr.","given":"Peter 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