{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:03:11Z","timestamp":1783609391289,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"DOI":"10.3389\/fped.2020.580226","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T14:59:09Z","timestamp":1605279549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Dexmedetomidine on Emergence Agitation and Recovery Quality Among Children Undergoing Surgery Under General Anesthesia: A Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3389","volume":"8","author":[{"given":"Xiaoli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiange","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1213\/00000539-199611000-00005","article-title":"Comparison of emergence and recovery characteristics of sevoflurane, desflurane, and halothane in pediatric ambulatory patients","volume":"83","author":"Welborn","year":"1996","journal-title":"Anesth Analg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1046\/j.1460-9592.2000.00560.x","article-title":"Emergence agitation in paediatric patients after sevoflurane anaesthesia and no surgery: a comparison with halothane","volume":"10","author":"Cravero","year":"2000","journal-title":"Paediatr Anaesth."},{"key":"B3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1213\/01.ane.0000250914.91881.a8","article-title":"Emergence delirium in children: many questions, few answers","volume":"104","author":"Vlajkovic","year":"2007","journal-title":"Anesth Analg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","article-title":"Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine","volume":"56","author":"Weerink","year":"2017","journal-title":"Clin Pharmacokinet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ."},{"key":"B6","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The cochrane collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Statist Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4103\/1658-354X.115363","article-title":"Prevention of sevoflurane related emergence agitation in children undergoing adenotonsillectomy: a comparison of dexmedetomidine and propofol","volume":"7","author":"Ali","year":"2013","journal-title":"Saudi J Anaesth."},{"key":"B9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12871-015-0124-7","article-title":"Dexmedetomidine decreases the emergence agitation in infant patients undergoing cleft palate repair surgery after general anesthesia","volume":"15","author":"Peng","year":"2015","journal-title":"BMC Anesthesiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1177\/0310057X0903700405","article-title":"The effects of dexmedetomidine and fentanyl on emergence characteristics after adenoidectomy in children","volume":"37","author":"Erdil","year":"2009","journal-title":"Anaesth Intensive Care."},{"key":"B11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.egja.2016.01.004","article-title":"Dexmedetomidine versus ketofol effect on the incidence of emergence agitation associated with sevoflurane-based anesthesia in children undergoing orthopedic surgery","volume":"32","author":"Ali","year":"2016","journal-title":"Egypt J Anaesth."},{"key":"B12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/ANA.0b013e31828cb6c0","article-title":"Effect of intraoperative dexmedetomidine on postoperative recovery profile of children undergoing surgery for spinal dysraphism","volume":"25","author":"Gupta","year":"2013","journal-title":"J Neurosurg Anesthesiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00540-019-02705-6","article-title":"Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial","volume":"34","author":"Cho","year":"2020","journal-title":"J Anesth."},{"key":"B14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1213\/01.ANE.0000094947.20838.8E","article-title":"Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children","volume":"98","author":"Ibacache","year":"2004","journal-title":"Anesth Analg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4103\/1658-354X.203020","article-title":"Effect of intranasal dexmedetomidine on emergence agitation after sevoflurane anesthesia in children undergoing tonsillectomy and\/or adenoidectomy","volume":"11","author":"El-Hamid","year":"2017","journal-title":"Saudi J Anaesth."},{"key":"B16","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3349\/ymj.2014.55.2.508","article-title":"Low-dose dexmedetomidine reduces emergence agitation after desflurane anaesthesia in children undergoing strabismus surgery","volume":"55","author":"Kim","year":"2014","journal-title":"Yonsei Med J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/j.1460-9592.2012.03802.x","article-title":"Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia","volume":"22","author":"Akin","year":"2012","journal-title":"Paediatr Anaesth."},{"key":"B18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1159\/000324554","article-title":"Dexmedetomidine use during strabismus surgery in agitated children","volume":"20","author":"Mizrak","year":"2011","journal-title":"Med Principles Pract."},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4103\/2279-042X.150051","article-title":"Emergence agitation prevention in paediatric ambulatory surgery: a comparison between intranasal dexmedetomidine and clonidine","volume":"4","author":"Mukherjee","year":"2015","journal-title":"J Res Pharm Pract."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1213\/ANE.0b013e3181ee82fa","article-title":"Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy","volume":"111","author":"Patel","year":"2010","journal-title":"Anesth Analg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/jcpt.13080","article-title":"The effects of dexmedetomidine and tramadol on post-operative pain and agitation, and extubation quality in paediatric patients undergoing adenotonsillectomy surgery: a randomized trial","volume":"45","author":"Koceroglu","year":"2020","journal-title":"J Clin Pharm Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0162785","DOI":"10.1371\/journal.pone.0162785","article-title":"Dexmedetomidine injection during strabismus surgery reduces emergence agitation without increasing the oculocardiac reflex in children: a randomized controlled trial","volume":"11","author":"Song","year":"2016","journal-title":"PLoS ONE."},{"key":"B23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jopan.2016.03.005","article-title":"Impact of dexmedetomidine on pediatric agitation in the postanesthesia care unit","volume":"33","author":"Li","year":"2018","journal-title":"J Perianesth Nurs."},{"key":"B24","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/pan.13397","article-title":"Dexmedetomidine for the reduction of emergence delirium in children undergoing tonsillectomy with propofol anesthesia: a double-blind, randomized study","volume":"28","author":"Tsiotou","year":"2018","journal-title":"Paediatr Anaesth."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e12140","DOI":"10.1097\/MD.0000000000012140","article-title":"Effects of different doses of intranasal dexmedetomidine on preoperative sedation and postoperative agitation in pediatric with total intravenous anesthesia undergoing adenoidectomy with or without tonsillectomy","volume":"97","author":"Li","year":"2018","journal-title":"Medicine."},{"key":"B26","first-page":"368","article-title":"Study of dose related effects of dexmedetomidine on laryngeal mask airway removal in children - a double blind randomized study","volume":"22","author":"Bhat","year":"2018","journal-title":"Anaesth Pain Intensive Care."},{"key":"B27","first-page":"16238","article-title":"Consequence of dexmedetomidine on emergence delirium following sevoflurane anesthesia in children with cerebral palsy","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/pan.12287","article-title":"Intranasal dexmedetomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: a double-blinded randomized controlled trial","volume":"24","author":"Sheta","year":"2014","journal-title":"Paediatr Anaesth."},{"key":"B29","doi-asserted-by":"publisher","first-page":"248","DOI":"10.4103\/0259-1162.118982","article-title":"Comparison between dexmedetomidine and midazolam premedication in pediatric patients undergoing ophthalmic day-care surgeries","volume":"7","author":"Bhadla","year":"2013","journal-title":"Anesth Essays Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1177\/0300060517699467","article-title":"Dexmedetomidine effect on emergence agitation and delirium in children undergoing laparoscopic hernia repair: a preliminary study","volume":"45","author":"Sun","year":"2017","journal-title":"J Int Med Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ijporl.2012.03.028","article-title":"Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study","volume":"76","author":"Meng","year":"2012","journal-title":"Int J Pediatr Otorhinolaryngol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s00540-012-1354-1","article-title":"The application of dexmedetomidine in children undergoing vitreoretinal surgery","volume":"26","author":"Lili","year":"2012","journal-title":"J Anesth."},{"key":"B33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.egja.2010.12.005","article-title":"Comparative study between prophylactic single dose of fentanyl and dexmedetomidine in the management of agitation after sevoflurane anesthesia in children","volume":"27","author":"Asaad","year":"2011","journal-title":"Egypt J Anaesth."},{"key":"B34","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1213\/ANE.0b013e3181e33429","article-title":"The effect of intraoperative dexmedetomidine on postoperative analgesia and sedation in pediatric patients undergoing tonsillectomy and adenoidectomy","volume":"111","author":"Olutoye","year":"2010","journal-title":"Anesth Analgesia."},{"key":"B35","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1460-9592.2004.01541.x","article-title":"Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy","volume":"15","author":"Guler","year":"2005","journal-title":"Paediatr Anaesth."},{"key":"B36","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12871-019-0892-6","article-title":"Efficacy of premedication with intranasal dexmedetomidine for removal of inhaled foreign bodies in children by flexible fiber optic bronchoscopy: a randomized, double-blind, placebo - controlled clinical trial","volume":"19","author":"Bi","year":"2019","journal-title":"BMC Anesthesiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bjan.2015.11.001","article-title":"Effectiveness of dexmedetomidine for emergence agitation in infants undergoing palatoplasty: a randomized controlled trial","volume":"66","author":"Boku","year":"2016","journal-title":"Brazil J Anesthesiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3349\/ymj.2014.55.1.209","article-title":"Effect of dexmedetomidine on sevoflurane requirements and emergence agitation in children undergoing ambulatory surgery","volume":"55","author":"Kim","year":"2014","journal-title":"Yonsei Med J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1111\/j.1460-9592.2005.01660.x","article-title":"Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?","volume":"15","author":"Shukry","year":"2005","journal-title":"Paediatr Anaesth."},{"key":"B40","doi-asserted-by":"publisher","first-page":"633","DOI":"10.4097\/kjae.2017.70.6.633","article-title":"A prospective randomized controlled double-blind trial to assess the effects of dexmedetomidine during cleft palate surgery","volume":"70","author":"Surana","year":"2017","journal-title":"Korean J Anesthesiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bjan.2016.02.015","article-title":"Effect of dexmedetomidine in children undergoing general anesthesia with sevoflurane: a meta-analysis","volume":"67","author":"Amorim","year":"2017","journal-title":"Brazil J Anesthesiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12871-019-0810-y","article-title":"Effect of ancillary drugs on sevoflurane related emergence agitation in children undergoing ophthalmic surgery: a Bayesian network meta-analysis","volume":"19","author":"Tan","year":"2019","journal-title":"BMC Anesthesiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"E184","DOI":"10.1002\/lary.26888","article-title":"Efficacy of dexmedetomidine for perioperative morbidities in pediatric tonsillectomy: a metaanalysis","volume":"128","author":"Cho","year":"2018","journal-title":"Laryngoscope."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e0128450","DOI":"10.1371\/journal.pone.0128450","article-title":"Effect of dexmedetomidine on preventing postoperative agitation in children: a meta-analysis","volume":"10","author":"Ni","year":"2015","journal-title":"PLoS ONE."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e99718","DOI":"10.1371\/journal.pone.0099718","article-title":"Effects of intravenous dexmedetomidine on emergence agitation in children under sevoflurane anesthesia: a meta-analysis of randomized controlled trials","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS ONE."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/jcpt.13133","article-title":"Comparative efficacy of ancillary drugs in sevoflurane-related emergence agitation after paediatric adenotonsillectomy: a Bayesian network meta-analysis","volume":"45","author":"Jiao","year":"2020","journal-title":"J Clin Pharm Ther."},{"key":"B47","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/j.1460-9592.2006.01845.x","article-title":"Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery","volume":"16","author":"Isik","year":"2006","journal-title":"Paediatr Anaesth."},{"key":"B48","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s12630-017-0917-x","article-title":"The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis","volume":"64","author":"Jun","year":"2017","journal-title":"Can J Anaesth."},{"key":"B49","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1177\/0300060517704595","article-title":"Effects of dexmedetomidine versus midazolam for premedication in paediatric anaesthesia with sevoflurane: a meta-analysis","volume":"45","author":"Feng","year":"2017","journal-title":"J Int Med Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"777","DOI":"10.6061\/clinics\/2014(11)12","article-title":"Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis","volume":"69","author":"Peng","year":"2014","journal-title":"Clinics."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.580226\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T14:59:11Z","timestamp":1605279551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.580226\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":50,"alternative-id":["10.3389\/fped.2020.580226"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.580226","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"article-number":"580226"}}