{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:24:27Z","timestamp":1787826267547,"version":"build-2784847793"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["606789"],"award-info":[{"award-number":["606789"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1058537"],"award-info":[{"award-number":["APP1058537"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1173731"],"award-info":[{"award-number":["APP1173731"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1175634"],"award-info":[{"award-number":["APP1175634"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VIDI 91716428"],"award-info":[{"award-number":["VIDI 91716428"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","award":["Operational Infrastructure Support Program"],"award-info":[{"award-number":["Operational Infrastructure Support Program"]}],"id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG 1909\/2-1"],"award-info":[{"award-number":["DFG 1909\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Continuous positive airway pressures (CPAP) used to assist preterm infants at birth are limited to 4\u20138 cmH<jats:sub>2<\/jats:sub>O due to concerns that high-CPAP may cause pulmonary overexpansion and adversely affect the cardiovascular system. We investigated the effects of high-CPAP on pulmonary (PBF) and cerebral (CBF) blood flows and jugular vein pressure (JVP) after birth in preterm lambs.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Preterm lambs instrumented with flow probes and catheters were delivered at 133\/146 days gestation. Lambs received low-CPAP (LCPAP: 5 cmH<jats:sub>2<\/jats:sub>O), high-CPAP (HCPAP: 15 cmH<jats:sub>2<\/jats:sub>O) or dynamic HCPAP (15 decreasing to 8 cmH<jats:sub>2<\/jats:sub>O at ~2 cmH<jats:sub>2<\/jats:sub>O\/min) for up to 30 min after birth.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean PBF was lower in the LCPAP [median (Q1\u2013Q3); 202 (48\u2013277) mL\/min, <jats:italic>p<\/jats:italic> = 0.002] compared to HCPAP [315 (221\u2013365) mL\/min] and dynamic HCPAP [327 (269\u2013376) mL\/min] lambs. CBF was similar in LCPAP [65 (37\u201378) mL\/min], HCPAP [73 (41\u2013106) mL\/min], and dynamic HCPAP [66 (52\u201381) mL\/min, <jats:italic>p<\/jats:italic> = 0.174] lambs. JVP was similar at CPAPs of 5 [8.0 (5.1\u201312.4) mmHg], 8 [9.4 (5.3\u201313.4) mmHg], and 15 cmH<jats:sub>2<\/jats:sub>O [8.6 (6.9\u201310.5) mmHg, <jats:italic>p<\/jats:italic> = 0.909]. Heart rate was lower in the LCPAP [134 (101\u2013174) bpm; <jats:italic>p<\/jats:italic> = 0.028] compared to the HCPAP [173 (139\u2013205)] and dynamic HCPAP [188 (161\u2013207) bpm] groups. Ventilation or additional caffeine was required in 5\/6 LCPAP, 1\/6 HCPAP, and 5\/7 dynamic HCPAP lambs (<jats:italic>p<\/jats:italic> = 0.082), whereas 3\/6 LCPAP, but no HCPAP lambs required intubation (<jats:italic>p<\/jats:italic> = 0.041), and 1\/6 LCPAP, but no HCPAP lambs developed a pneumothorax (<jats:italic>p<\/jats:italic> = 0.632).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> High-CPAP did not impede the increase in PBF at birth and supported preterm lambs without affecting CBF and JVP.<\/jats:p>","DOI":"10.3389\/fped.2020.584138","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T19:35:36Z","timestamp":1611344136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["High-CPAP Does Not Impede Cardiovascular Changes at Birth in Preterm 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