{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:43:30Z","timestamp":1767206610448,"version":"build-2238731810"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    A meta-analysis published in 2015 showed a significant association between low platelet counts in the first day(s) of life and risk of patent ductus arteriosus (PDA). The meta-analysis pooled data from 11 studies cohorts (3,479 preterm infants).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To update the meta-analysis by adding new studies on the topic and including other platelet parameters different from platelet counts.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    PubMed\/Medline and Embase databases were searched. Random-effects risk ratios (RR) and differences in means (DM) and 95% confidence intervals (CI) were calculated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    We included 31 studies (7,638 infants). Meta-analysis showed that the risk of developing any PDA was significantly associated with platelet counts&amp;lt;150 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (11 studies, RR 1.58, 95% CI 1.28 to 1.95), and &amp;lt;100 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (7 studies, RR 1.61, 95% CI 1.14 to 2.28), but not &amp;lt;50 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (4 studies, RR 1.34, 95% CI 0.77 to 2.32). Risk of developing hemodynamically significant PDA (hsPDA) was significantly associated with platelet counts&amp;lt;150 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (12 studies, RR 1.33, 95% CI 1.09 to 1.63), and &amp;lt;100 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (7 studies, RR 1.39, 95% CI 1.06 to 1.82), but not &amp;lt;50 x 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (6 studies, RR 1.24, 95% CI 0.86 to 1.79). Infants with hsPDA had significantly lower mean platelet counts (19 studies, DM 22.0 x 10\n                    <jats:sup>9<\/jats:sup>\n                    , 95% CI 14.9 to 29.1) and platelet mass (11 studies, DM 214.4, 95% CI 131.2 to 297.5) and significantly higher platelet distribution width (PDW, 9 studies, DM \u22120.53, 95% CI \u22121.01 to \u22120.05) than infants without hsPDA. Meta-analysis could not demonstrate significant differences in mean platelet volume (MPV).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Compared to the previous analysis, this updated meta-analysis included 21 additional studies that provide stronger evidence of the association between low platelet counts and PDA\/hsPDA. Other platelet parameters such as platelet mass and PDW are also associated with hsPDA risk. However, the low number of platelets may be an epiphenomenon associated with the maturity and clinical stability of preterm infants rather than a contributing factor in the pathogenesis of PDA.\n                  <\/jats:p>","DOI":"10.3389\/fped.2020.613766","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:59:36Z","timestamp":1611104376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: An Updated Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"8","author":[{"given":"Gema","family":"Gonz\u00e1lez-Luis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ghirardello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Bas-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Cavallaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald I","family":"Clyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12887-018-1215-7","article-title":"Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial)","volume":"18","author":"Hundscheid","year":"2018","journal-title":"BMC Pediatrics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000506988","article-title":"Defining \u201chaemodynamic significance\u201d of the patent ductus arteriosus: do we have all the answers?","volume":"117","author":"Smith","year":"2020","journal-title":"Neonatology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.clp.2020.05.007","article-title":"Patent ductus arteriosus\u2014time for a definitive trial","volume":"47","author":"Mitra","year":"2020","journal-title":"Clin Perinatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.jpeds.2015.08.023","article-title":"The patent ductus arteriosus problem: infants who still need treatment","volume":"167","author":"Reese","year":"2015","journal-title":"J Pediatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jpeds.2018.09.012","article-title":"PDA-TOLERATE trial: an exploratory randomized controlled trial of treatment of moderate-to-large patent ductus arteriosus at 1 week of age","volume":"205","author":"Clyman","year":"2019","journal-title":"J Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.clp.2015.11.008","article-title":"Recent advances in the treatment of preterm newborn infants with patent ductus arteriosus","volume":"43","author":"Sallmon","year":"2016","journal-title":"Clin Perinatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1038\/s41372-019-0483-x","article-title":"Transcatheter patent ductus arteriosus closure\u2014will history repeat itself?","volume":"39","author":"Clyman","year":"2019","journal-title":"J Perinatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3389\/fped.2020.00541","article-title":"Spontaneous closure of the ductus arteriosus in preterm infants: a systematic review","volume":"8","author":"de Klerk","year":"2020","journal-title":"Front Pediatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fped.2020.00434","article-title":"An observational, prospective, multicenter, registry-based cohort study comparing conservative and medical management for patent ductus arteriosus","volume":"8","author":"Okulu","year":"2020","journal-title":"Front Pediatr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e20201209","DOI":"10.1542\/peds.2020-1209","article-title":"Patent ductus arteriosus of the preterm infant","volume":"146","author":"Hamrick","year":"2020","journal-title":"Pediatrics."},{"key":"B11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nm.2060","article-title":"Platelets contribute to postnatal occlusion of the ductus arteriosus","volume":"16","author":"Echtler","year":"2010","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.earlhumdev.2012.05.007","article-title":"Low platelet count is associated with ductus arteriosus patency in preterm newborns","volume":"88","author":"Dizdar","year":"2012","journal-title":"Early Hum Dev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1055\/s-0032-1324702","article-title":"Relationship between platelet count and volume and spontaneous and pharmacological closure of ductus arteriosus in preterm infants","volume":"30","author":"Dani","year":"2013","journal-title":"Am J Perinatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/nm0111-29","article-title":"Does thrombocytopenia contribute to patent ductus arteriosus?","volume":"17","author":"Fujioka","year":"2011","journal-title":"Nat Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.jpeds.2010.11.018","article-title":"Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment","volume":"158","author":"Shah","year":"2011","journal-title":"J Pediatr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1542\/peds.2012-0499","article-title":"Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus","volume":"130","author":"Sallmon","year":"2012","journal-title":"Pediatrics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/ped.12199","article-title":"Perinatal factors in patent ductus arteriosus in very low-birthweight infants","volume":"56","author":"Chen","year":"2014","journal-title":"Pediatr Int"},{"key":"B18","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000362432","article-title":"Platelet counts in the first seven days of life and patent ductus arteriosus in preterm very low-birth-weight infants","volume":"106","author":"Bas-Suarez","year":"2014","journal-title":"Neonatology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000431281","article-title":"Platelet counts and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis","volume":"108","author":"Simon","year":"2015","journal-title":"Neonatology"},{"key":"B20","unstructured":"WellsGA\n            SheaB\n            O'ConnellD\n            PetersonJ\n            WelchV\n            LososM\n          The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analyses2019"},{"key":"B21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4149\/BLL_2017_094","article-title":"Association between neutrophil\/lymphocyte ratio with ductus arteriosus patency in preterm newborns","volume":"118","author":"Temel","year":"2017","journal-title":"Bratisl Lek Listy"},{"key":"B23","doi-asserted-by":"publisher","first-page":"101226","DOI":"10.1016\/j.ppedcard.2020.101226","article-title":"Platelets and platelet derived growth factor and ductus arteriosus in preterm neonates","volume":"57","author":"Ahmed","year":"2020","journal-title":"Prog Pediatr Cardiol."},{"key":"B24","first-page":"687","article-title":"Is the first postnatal platelet mass as an indicator of patent ductus arteriosus?","volume":"22","author":"Akar","year":"2019","journal-title":"Arch Iran Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3109\/14767058.2015.1067296","article-title":"Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus?","volume":"29","author":"Demir","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1080\/14767058.2018.1536743","article-title":"Is high platelet distribution width in the first hours of life can predict hemodynamically significant patent ductus arteriosus in preterm newborns?","volume":"33","author":"Demirel","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B27","first-page":"242","article-title":"Platelets and platelet-derived growth factor in closure of the ductus arteriosus","volume":"57","author":"Eng\u00fcr","year":"2015","journal-title":"Turk J Pediatr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000507553","article-title":"The thromboelastographic profile at birth in very preterm newborns with patent ductus arteriosus","volume":"117","author":"Ghirardello","year":"2020","journal-title":"Neonatology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.pedneo.2017.01.006","article-title":"Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity","volume":"59","author":"Kahvecioglu","year":"2018","journal-title":"Pediatr Neonatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15513815.2019.1686786","article-title":"Utility of the platelet-to-lymphocyte ratio in diagnosing and predicting treatment success in preterm neonates with patent ductus arteriosus","volume":"38","author":"Karabulut","year":"2019","journal-title":"Fetal Pediatr Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5336\/cardiosci.2018-62380","article-title":"The fate of patent ductus arteriosus is not affected by platelet count and mean platelet volume in premature infants <32 gestational weeks","volume":"30","author":"K\u00fc\u00e7\u00fck","year":"2018","journal-title":"Turkiye Klinikleri Cardiovascular Sciences"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e20161627","DOI":"10.1542\/peds.2016-1627","article-title":"Preterm thrombocytopenia and delay of ductus arteriosus closure","volume":"138","author":"Kulkarni","year":"2016","journal-title":"Pediatrics."},{"key":"B33","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/09537104.2016.1203398","article-title":"C-reactive protein, platelets, and patent ductus arteriosus","volume":"27","author":"Meinarde","year":"2016","journal-title":"Platelets"},{"key":"B34","article-title":"Korrelation eines h\u00e4modynamisch relevanten persistierenden Ductus arteriosus mit einer Thrombozytopenie in den ersten zehn Lebenstagen sowie die Auswirkungen einer Thrombozytopenie auf das Outcome einer Behandlung mit NSAID","author":"Morawietz","year":"2016"},{"key":"B35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MBC.0000000000000520","article-title":"Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?","volume":"28","author":"Olukman","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.32677\/IJCH.2020.v07.i03.003","article-title":"Association of patent ductus arteriosus size with clinical features and short-term outcomes in preterm infants less than 34 weeks","volume":"7","author":"Shekharappa","year":"2020","journal-title":"Indian J Child Health."},{"key":"B37","doi-asserted-by":"publisher","first-page":"168","DOI":"10.11648\/j.ajp.20200602.29","article-title":"Risk factors of patent ductus arteriosus in preterm","volume":"6","author":"Kusuma","year":"2020","journal-title":"Am J Pediatr"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e050227","DOI":"10.7363\/050227","article-title":"PDA management in VLBW infants: experience of a level III NICU","volume":"5","author":"Oliveira","year":"2016","journal-title":"J Pediatr Neonat Individ Med (JPNIM)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.33421\/inmp.2019150","article-title":"Trombocitopenia como indicador predictivo de cierre deficitario de ductus arterioso en prematuros del Instituto Nacional Materno Perinatal","volume":"8","author":"Salda\u00f1a-D\u00edaz","year":"2019","journal-title":"Revista Peruana de Investigaci\u00f3n Materno Perinatal"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1055\/s-0039-1688821","article-title":"Useful platelet indices for the diagnosis and follow-up of patent ductus arteriosus","volume":"36","author":"Kazanci","year":"2019","journal-title":"Am J Perinatol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e22616","DOI":"10.1002\/jcla.22616","article-title":"A promising, novel index in the diagnosis and follow-up of patent ductus arteriosus: red cell distribution width-to-platelet ratio","volume":"32","author":"\u00d6zer Bekmez","year":"2018","journal-title":"J Clin Lab Anal"},{"key":"B42","article-title":"Spontaneous and pharmacological closure of PDAs in ELBW infants is influenced by thrombocyto-penia (abstract)","volume-title":"E-PAS 21","author":"Dwarakanath","year":"2011"},{"key":"B43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jpeds.2012.12.035","article-title":"Patent ductus arteriosus, low platelets, cyclooxygenase inhibitors, and intraventricular hemorrhage in very low birth weight preterm infants","volume":"163","author":"Brunner","year":"2013","journal-title":"J Pediatr"},{"key":"B44","article-title":"Dynamic changes in platelets caused by shear stress in aortic valve stenosis","volume-title":"Clin Hemorheol Microcirc.","author":"Kanda","year":"2020"},{"key":"B45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1159\/000329925","article-title":"Platelet transfusion in the neonatal intensive care unit: benefits, risks, alternatives","volume":"100","author":"Christensen","year":"2011","journal-title":"Neonatology"},{"key":"B46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/9780470743386.ch20","article-title":"Meta-regression","volume-title":"Introduction to Meta-Analysis","author":"Borenstein","year":"2009"},{"key":"B47","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2141.2011.08892.x","article-title":"How I manage neonatal thrombocytopenia","volume":"156","author":"Chakravorty","year":"2012","journal-title":"Br J Haematol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1182\/asheducation.V2012.1.506.3798532","article-title":"Platelets in the neonatal period: developmental differences in platelet production, function, and hemostasis and the potential impact of therapies","volume":"2012","author":"Sola-Visner","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"B49","doi-asserted-by":"publisher","first-page":"049","DOI":"10.1055\/s-2003-37948","article-title":"Risk factors for neonatal thrombocytopenia in preterm infants","volume":"20","author":"Beiner","year":"2003","journal-title":"Am J Perinatol"},{"key":"B50","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2008.02.004","article-title":"Neonatal thrombocytopenia","volume-title":"Seminars in Fetal And Neonatal Medicine","author":"Roberts","year":"2008"},{"key":"B51","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fendo.2019.00058","article-title":"Intrauterine growth restriction and patent ductus arteriosus in very and extremely preterm infants: a systematic review and meta-analysis","volume":"10","author":"Villamor-Martinez","year":"2019","journal-title":"Front Endocrinol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e0138114","DOI":"10.1371\/journal.pone.0138114","article-title":"Chorioamnionitis and patent ductus arteriosus: a systematic review and meta-analysis","volume":"10","author":"Park","year":"2015","journal-title":"PLoS ONE"},{"key":"B53","doi-asserted-by":"publisher","first-page":"37967","DOI":"10.1038\/srep37967","article-title":"Chorioamnionitis appears not to be a risk factor for patent ductus arteriosus in preterm infants: a systematic review and meta-analysis","volume":"6","author":"Behbodi","year":"2016","journal-title":"Sci Rep"},{"key":"B54","article-title":"Association of chorioamnionitis and patent ductus arteriosus in a national US cohort","volume-title":"J Perinatol.","author":"Green","year":"2020"},{"key":"B55","doi-asserted-by":"publisher","first-page":"H732","DOI":"10.1152\/ajpheart.00838.2013","article-title":"Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA","volume":"307","author":"Vucovich","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3109\/09537104.2014.963542","article-title":"Clinical significance of platelet-associated hematological parameters as an early supplementary diagnostic tool for sepsis in thrombocytopenic very-low-birth-weight infants","volume":"26","author":"Kim","year":"2015","journal-title":"Platelets"},{"key":"B57","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4103\/2249-4847.140399","article-title":"Effect of gestational age, prematurity and birth asphyxia on platelet indices in neonates","volume":"3","author":"Kannar","year":"2014","journal-title":"J Clin Neonatol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1538-7836.2009.03584.x","article-title":"Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis","volume":"8","author":"Chu","year":"2010","journal-title":"J Thromb Haemost."},{"key":"B59","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fped.2020.00090","article-title":"Using platelet parameters to anticipate morbidity and mortality among preterm neonates: a retrospective study","volume":"8","author":"Go","year":"2020","journal-title":"Front Pediatr."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s00417-015-3047-6","article-title":"Mean platelet volume in retinopathy of prematurity","volume":"253","author":"Tao","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1055\/s-0031-1274503","article-title":"Mean platelet volume and risk of bronchopulmonary dysplasia and intraventricular hemorrhage in extremely preterm infants","volume":"28","author":"Dani","year":"2011","journal-title":"Am J Perinatol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1055\/s-0039-3402687","article-title":"The role of platelets in premature neonates with intraventricular hemorrhage: a systematic review and meta-analysis","volume":"46","author":"Grevsen","year":"2020","journal-title":"Semin Thromb Hemost"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e21649","DOI":"10.1097\/MD.0000000000021649","article-title":"Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis","volume":"99","author":"Wang","year":"2020","journal-title":"Medicine"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1047951120000943","article-title":"Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus","volume":"30","author":"Sallmon","year":"2020","journal-title":"Cardiol Young."},{"key":"B65","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3109\/14767058.2016.1163684","article-title":"The association of platelets with failed patent ductus arteriosus closure after a primary course of indomethacin or ibuprofen: a systematic review and meta-analysis","volume":"30","author":"Mitra","year":"2017","journal-title":"J Matern-Fetal Neonat Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0022-3476(05)81705-6","article-title":"A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants","volume":"123","author":"Andrew","year":"1993","journal-title":"J Pediatr"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e20182565","DOI":"10.1542\/peds.2018-2565","article-title":"Platelet transfusion for PDA closure in preterm infants: a randomized controlled trial","volume":"143","author":"Kumar","year":"2019","journal-title":"Pediatrics"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.blre.2018.10.001","article-title":"Are thrombocytopenia and platelet transfusions associated with major bleeding in preterm neonates? A systematic review","volume":"36","author":"Fustolo-Gunnink","year":"2019","journal-title":"Blood Rev"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1182\/blood.2019000899","article-title":"Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death","volume":"134","author":"Fustolo-Gunnink","year":"2019","journal-title":"Blood"},{"key":"B70","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1055\/s-0039-1691775","article-title":"Updates in red blood cell and platelet transfusions in preterm neonates","volume":"36","author":"Lopriore","year":"2019","journal-title":"Am J Perinatol."}],"updated-by":[{"DOI":"10.3389\/fped.2021.694606","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000}}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.613766\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T12:03:08Z","timestamp":1621425788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.613766\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":70,"alternative-id":["10.3389\/fped.2020.613766"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.613766","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"article-number":"613766"}}