{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:59:47Z","timestamp":1770458387679,"version":"3.49.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study was to describe our experience with transcatheter device closure of patent ductus arteriosus (PDA) in symptomatic low-birth-weight premature infants.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We performed a retrospective study of infants born with a birth body weight of &amp;lt; 2,000 g and admitted to National Cheng Kung University Hospital from September 2014 to December 2019. Basic demographic and clinical information as well as echocardiographic and angiographic data were recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twenty-five premature infants (11 boys and 14 girls) born at gestational ages ranging between 22 and 35 weeks (mean, 25 weeks) were identified. The mean age at procedure was 34.5 \u00b1 5.5 days, and the mean weight was 1,209 \u00b1 94 g (range, 478\u20131,980 g). The mean diameter of the PDA was 3.4 \u00b1 0.2 mm (range, 2.0\u20135.4 mm). The following devices were used in this study: Amplatzer Ductal Occluder II additional size (<jats:italic>n<\/jats:italic> = 20), Amplatzer Vascular Plug I (<jats:italic>n<\/jats:italic> = 1), and Amplatzer Vascular Plug II (<jats:italic>n<\/jats:italic> = 4). Complete closure was achieved in all patients. The mean follow-up period was 30.1 \u00b1 17.3 months (range, 6\u201368 months). In total, 3 patients had left pulmonary artery (LPA) stenosis and 1 patient had coarctation of the aorta during the follow-up period. Younger procedure age and smaller procedure body weight were significantly associated with these obstructions.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Performing transcatheter PDA closure in symptomatic premature infants weighing more than 478 g is feasible using currently available devices; moreover, the procedure serves as an alternative to surgery.<\/jats:p>","DOI":"10.3389\/fped.2020.615919","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:29:56Z","timestamp":1610652596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Transcatheter Closure of Patent Ductus Arteriosus in Premature Infants With Very Low Birth Weight"],"prefix":"10.3389","volume":"8","author":[{"given":"Jieh-Neng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Chieh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Ling","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Tzu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0146-0005(03)00055-7","article-title":"The NICHD neonatal research network: changes in practice and outcomes during the first 15 years","volume":"27","author":"Fanaroff","year":"2003","journal-title":"Semin Perinatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e138","DOI":"10.1542\/peds.2008-2418","article-title":"Failure of ductus arteriosus closure is associated with increased mortality in preterm infants","volume":"123","author":"Noori","year":"2009","journal-title":"Pediatrics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/ANC.0000000000000340","article-title":"Patent ductus arteriosus in the preterm infant: diagnostic and treatment options","volume":"17","author":"Prescott","year":"2017","journal-title":"Adv Neonatal Care."},{"key":"B4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.4172\/2167-0897.1000238","article-title":"Controversies in the management of patent ductus arteriosus in preterm infants","volume":"5","author":"Chaudhary","year":"2016","journal-title":"J Neonatal Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.pedneo.2014.04.003","article-title":"Management of patent ductus arteriosus in premature babies: the art and the sciences","volume":"55","author":"Wang","year":"2014","journal-title":"Pediatr Neonatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/chd.12712","article-title":"Overview of transcatheter patent ductus arteriosus closure in preterm infants","volume":"14","author":"Myriam","year":"2019","journal-title":"Congenit Heart Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"F244","DOI":"10.1136\/adc.2006.104596","article-title":"Conservative treatment for patent ductus arteriosus in the preterm","volume":"92","author":"Vanhaesebrouck","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/jp.2011.102","article-title":"What happens when the patent ductus arteriosus is treated less aggressively in very low birth weight infants?","volume":"32","author":"Kaempf","year":"2012","journal-title":"J Perinatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.2174\/0929867321666140304095434","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) in the management of patent ductus arteriosus (PDA) in preterm infants and variations in attitude in clinical practice: a flight around the world","volume":"21","author":"Irmesi","year":"2014","journal-title":"Curr Med Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.1542\/peds.2008-2232","article-title":"A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants","volume":"124","author":"Richards","year":"2009","journal-title":"Pediatrics."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e000424","DOI":"10.1161\/JAHA.113.000424","article-title":"Safety of percutaneous patent ductus arteriosus closure: an unselected multicenter population experience","volume":"2","author":"El-Said","year":"2013","journal-title":"J Am Heart Assoc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1016\/j.jcin.2016.09.019","article-title":"Transcatheter closure of patent ductus arteriosus in extremely premature newborns: early results and midterm follow-up","volume":"9","author":"Zahn","year":"2016","journal-title":"JACC Cardiovasc Interv."},{"key":"B14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/chd.12704","article-title":"Percutaneous closure of the patent ductus arteriosus: opportunities moving forward","volume":"14","author":"Mitchell","year":"2019","journal-title":"Congenit Heart Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/ccd.27091","article-title":"Transcatheter closure of hemodynamic significant patent ductus arteriosus in 32 premature infants by amplatzer ductal occluder additional size-ADOIIAS","volume":"90","author":"Morville","year":"2017","journal-title":"Catheter Cardiovasc Interv."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1002\/ccd.27824","article-title":"Use of Amplatzer vascular plugs and Amplatzer duct occluder II additional sizes for occlusion of patent ductus arteriosus: a multi-institutional study","volume":"92","author":"VanLoozen","year":"2018","journal-title":"Catheter Cardiovasc Interv."},{"key":"B17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/ccd.24905","article-title":"Closure of patent ductus arteriosus in children, small infants, and premature babies with Amplatzer duct occluder II additional sizes: multicenter study","volume":"82","author":"Sungur","year":"2013","journal-title":"Catheter Cardiovasc Interv."},{"key":"B18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s00246-012-0393-6","article-title":"Comparison of the efficacy of different-sized Amplatzer duct occluders (I, II, and II AS) in children weighing less than 10 kg","volume":"34","author":"Baspinar","year":"2013","journal-title":"Pediatr Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/ccd.27995","article-title":"Results of the combined U.S. multicenter postapproval study of the Nit-Occlud PDA device for percutaneous closure of patent ductus arteriosus","volume":"93","author":"Kobayashi","year":"2019","journal-title":"Catheter Cardiovasc Interv."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/ccd.26878","article-title":"Initial clinical experience with the Medtronic Micro Vascular Plug\u2122 in transcatheter occlusion of PDAs in extremely premature infants","volume":"89","author":"Sathanandam","year":"2017","journal-title":"Catheter Cardiovasc Interv."},{"key":"B21","doi-asserted-by":"publisher","first-page":"F198","DOI":"10.1136\/archdischild-2016-312582","article-title":"Transcatheter occlusion of the patent ductus arteriosus in premature infants weighing less than 1200 g","volume":"103","author":"Morville","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.iccl.2018.08.004","article-title":"New patent ductus arteriosus closure devices and techniques","volume":"8","author":"Agrawal","year":"2019","journal-title":"Interv Cardiol Clin."},{"key":"B23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jcin.2010.01.016","article-title":"Transcatheter occlusion of patent ductus arteriosus in pre-term infants","volume":"3","author":"Francis","year":"2010","journal-title":"JACC Cardiovasc Interv."},{"key":"B24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/ccd.25534","article-title":"A novel technique for transcatheter patent ductus arteriosus closure in extremely preterm infants using commercially available technology","volume":"85","author":"Zahn","year":"2015","journal-title":"Catheter Cardiovasc Interv."},{"key":"B25","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/ccd.28942","article-title":"Incidence and fate of device-related left pulmonary artery stenosis and aortic coarctation in small infants undergoing transcatheter patent ductus arteriosus closure","volume":"96","author":"Tomasulo","year":"2020","journal-title":"Catheter Cardiovasc Interv."},{"key":"B26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/ccd.26287","article-title":"Morphologic characterization of the patent ductus arteriosus in the premature infant and the choice of transcatheter occlusion device","volume":"87","author":"Philip","year":"2016","journal-title":"Catheter Cardiovasc Interv."},{"key":"B27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/0002-9149(89)90064-7","article-title":"Angiographic classification of the Isolated, persistently patent ductus arteriosus and implications for percutaneous catheter occlusion","volume":"63","author":"Krichenko","year":"1989","journal-title":"Am J Cardiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1161\/CIRCULATIONAHA.105.592063","article-title":"Patent ductus arteriosus","volume":"114","author":"Schneider","year":"2006","journal-title":"Circulation."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e1024","DOI":"10.1542\/peds.2013-3431","article-title":"PDA ligation and health outcomes: a meta-analysis","volume":"133","author":"Weisz","year":"2014","journal-title":"Pediatrics."},{"key":"B30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/chd.12700","article-title":"Can transcatheter PDA closure be performed in neonates \u22641000 grams? The Memphis experience","volume":"14","author":"Sathanandam","year":"2019","journal-title":"Congenit Heart Dis."},{"key":"B31","unstructured":"U.S. Food and Drug AdministrationCadenza Document"},{"key":"B32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ijcard.2020.02.065","article-title":"Device deformation and left pulmonary artery obstruction after transcatheter patent ductus arteriosus closure in preterm infants","volume":"312","author":"Chien","year":"2020","journal-title":"Int J Cardiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4103\/1947-2714.183011","article-title":"Ultrasound-guided central line insertion and standard peripherally inserted catheter placement in preterm infants: comparing results from prospective study in a single-center","volume":"8","author":"Al Hamod","year":"2016","journal-title":"N Am J Med Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/0002-8703(92)90435-X","article-title":"Venous sheath to facilitate cardiac catheterization via the umbilical vein","volume":"124","author":"Appleton","year":"1992","journal-title":"Am Heart J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/ccd.22637","article-title":"Echocardiographically guided catheter closure of arterial ducts in small preterm infants on the neonatal intensive care unit","volume":"77","author":"Bentham","year":"2011","journal-title":"Catheter Cardiovasc Interv."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.615919\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T07:28:28Z","timestamp":1611127708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2020.615919\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":35,"alternative-id":["10.3389\/fped.2020.615919"],"URL":"https:\/\/doi.org\/10.3389\/fped.2020.615919","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"article-number":"615919"}}