{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:22:05Z","timestamp":1792297325653,"version":"4.4.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Secondary hyperparathyroidism (HPT) is a common complication of end-stage renal disease (ESRD) and may be an important precipitating factor for the development of myelofibrosis. However, there have been only a few reports on myelofibrosis caused by secondary HPT in children. We describe a case of a 15-year-old boy with myelofibrosis due to secondary HPT who was successfully treated with hemodialysis, erythropoietin, phosphate binders, and activated vitamin D agents. The patient had no past medical history and had been admitted to the hospital for abdominal pain. Routine blood examination revealed pancytopenia combined with renal impairment. Hyperphosphatemia, decreased 1,25-dehydroxyvitamin D, decreased serum calcium, and increased parathyroid hormone (PTH) levels were observed. Bone marrow biopsy confirmed myelofibrosis and renal biopsy revealed nephronophthisis (NPHP). The possibility of renal osteodystrophy and myelofibrosis due to secondary HPT was considered. Hemodialysis and erythropoietin were initiated and combined therapy with a phosphate binder and an active vitamin D agent achieved greater reduction of PTH levels, along with improvement of pancytopenia. As medical treatment for secondary HPT can lead to a reversal of myelofibrosis and avoid parathyroidectomy in children, prompt recognition of this condition has major implications for treatment. Therefore, despite its rarity, pediatricians should consider myelofibrosis due to secondary HPT as a cause of pancytopenia in patients with chronic kidney disease.<\/jats:p>","DOI":"10.3389\/fped.2021.550158","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T06:49:50Z","timestamp":1620715790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Effects of Secondary Hyperparathyroidism Treatment on Improvement of Juvenile Nephronophthisis-Induced Pancytopenia and Myelofibrosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Keishiro","family":"Amano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s12308-015-0256-1","article-title":"Myeloproliferative neoplasms in children","volume":"8","author":"Hofmann","year":"2015","journal-title":"J Hematopathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1159\/000188961","article-title":"Myelofibrosis secondary to renal osteodystrophy","volume":"72","author":"Nomura","year":"1996","journal-title":"Nephron."},{"key":"B3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1056\/NEJM199301213280304","article-title":"Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia","volume":"328","author":"Rao","year":"1993","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1172\/JCI11296","article-title":"Activated parathyroid hormone\/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone","volume":"107","author":"Calvi","year":"2001","journal-title":"J Clin Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ajpath.2011.10.028","article-title":"A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis","volume":"180","author":"Ohishi","year":"2012","journal-title":"Am J Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s40620-019-00677-0","article-title":"New scenarios in secondary hyperparathyroidism: etelcalcetide. 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