{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:03:38Z","timestamp":1788455018934,"version":"build-2803163510"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Aims:<\/jats:bold> To investigate the association of vitamin D deficiency with cardiovascular autonomic nervous system function in children and adolescents with vasovagal syncope (VVS).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study recruited 76 pediatric patients with VVS and 15 healthy children. The 25-hydroxyvitamin D levels in serum among the participants were evaluated. Heart rate variability analysis including SDNN, rMSSD, and SDANN was tested in patients with VVS. The correlation between indices of time-domain analysis and serum vitamin D status of the children with VVS was investigated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In this work, 25-hydroxyvitamin D levels in serum among VVS cases remarkably decreased compared with those among healthy controls (48.76 \u00b1 19.25 vs. 67.62 \u00b1 15.46 nmol\/L, <jats:italic>p<\/jats:italic> &amp;lt; 0.01). The vitamin D deficient patients with VVS exhibited a lower rMSDD value compared to the non-deficient group with VVS (45.56 \u00b1 16.87 vs. 61.90 \u00b1 20.38 ms, <jats:italic>p<\/jats:italic> &amp;lt; 0.001, respectively). Pearson correlation analysis indicated that serum 25-hydroxyvitamin D levels had positive correlation with rMSDD values (<jats:italic>r<\/jats:italic> = 0.466, <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> As suggested by our data, VVS children and adolescents with vitamin D deficiency may have cardiac autonomic dysfunction and cardiac vagal tone decreases with the reduction in vitamin D level.<\/jats:p>","DOI":"10.3389\/fped.2021.575923","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T06:09:40Z","timestamp":1614233380000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Vitamin D Deficiency and Vasovagal Syncope in Children and 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