{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:06:07Z","timestamp":1778619967928,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>The relationship between eosinophils\/basophils and allergic sensitization is not clear in pediatric adenotonsillar hypertrophy (ATH). The objective of this study is to investigate the relationship between eosinophil\/basophil counts and peripheral specific IgE levels, and identify the common allergens in children with ATH. We initially screened 1,031 consecutive children who underwent adenotonsillectomy in our department from June 2018 to June 2019, and finally included 676 children. The eosinophil count, basophil count, and levels of specific IgE were collected. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient. Logistic regression analyses were performed to evaluate the odds ratios (ORs) for atopy after controlling for age, sex, vitamin D, BMI, and visiting season. Both the eosinophil and basophil counts in atopic participants were significantly higher compared to non-atopic participants. The eosinophil count correlated with the levels of IgE specific to all allergens, and eosinophilia was independently associated with all tested atopy allergens other than atopy to dander after multivariate adjustment. Additionally, the basophil count correlated with the IgE levels specific to A. <jats:italic>alternate<\/jats:italic> and food mix, and basophilia was still significantly associated with atopy to food mix after multivariable adjustment. Furthermore, among allergic participants, D. <jats:italic>farinae<\/jats:italic> was the most prevalent allergen, followed by food mix, D. <jats:italic>pteronyssinus<\/jats:italic>, and A. <jats:italic>alternata<\/jats:italic>. In conclusion, eosinophils were more relevant to allergic sensitization than basophils, with eosinophils being significantly associated with all tested atopy allergens apart from dander, and basophils being associated with atopy to food mix. Furthermore, D. <jats:italic>farinae<\/jats:italic> was the most prevalent allergen and may be indicative of desensitization therapy.<\/jats:p>","DOI":"10.3389\/fped.2021.598063","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T06:36:08Z","timestamp":1617172568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Eosinophils Are More Strongly Relevant to Allergic Sensitization Than Basophils in Pediatric Adenotonsillar Hypertrophy"],"prefix":"10.3389","volume":"9","author":[{"given":"Juanjuan","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.smrv.2017.06.001","article-title":"Prevalence of adenoid hypertrophy: a systematic review and meta-analysis","volume":"38","author":"Pereira","year":"2018","journal-title":"Sleep Med Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1399-3038.2010.01012.x","article-title":"Non-surgical treatment of adenoidal hypertrophy: the role of treating IgE-mediated inflammation","volume":"21","author":"Scadding","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ijporl.2011.01.026","article-title":"Is there any correlation between allergy and adenotonsillar tissue hypertrophy?","volume":"75","author":"Sadeghi-Shabestari","year":"2011","journal-title":"Int J pediatr Otorhinolaryngol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ijporl.2006.12.018","article-title":"An analysis of the incidence of adenoid hypertrophy in allergic children","volume":"71","author":"Modrzynski","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/00016480500265976","article-title":"IgE-positive plasma cells are present in adenoids of atopic children","volume":"126","author":"Papatziamos","year":"2006","journal-title":"Acta Otolaryngol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00011-009-0042-6","article-title":"Mast cells and eosinophils: the two key effector cells in allergic inflammation","volume":"58","author":"Minai-Fleminger","year":"2009","journal-title":"Inflamm Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/all.12321","article-title":"Eosinophil activities modulate the immune\/inflammatory character of allergic respiratory responses in mice","volume":"69","author":"Jacobsen","year":"2014","journal-title":"Allergy"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.anai.2014.04.002","article-title":"Changing roles of eosinophils in health and disease","volume":"113","author":"Furuta","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijporl.2018.02.008","article-title":"Can the number of eosinophils in adenoid and tonsil tissue determine the allergy in children?","volume":"108","author":"Ekici","year":"2018","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/j.1600-0625.2006.00477.x","article-title":"The 21st century renaissance of the basophil? 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