{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:55:30Z","timestamp":1790934930372,"version":"4.1.0"},"reference-count":155,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Severe trauma is the most common cause of mortality in children and is associated with a high socioeconomic burden. The most frequently injured organs in children are the head and thorax, followed by the extremities and by abdominal injuries. The efficient and early assessment and management of these injuries is essential to improve patients' outcome. Physical examination as well as imaging techniques like ultrasound, X-ray and computer tomography are crucial for a valid early diagnosis. Furthermore, laboratory analyses constitute additional helpful tools for the detection and monitoring of pediatric injuries. Specific inflammatory markers correlate with post-traumatic complications, including the development of multiple organ failure. Other laboratory parameters, including lactate concentration, coagulation parameters and markers of organ injury, represent further clinical tools to identify trauma-induced disorders. In this review, we outline and evaluate specific biomarkers for inflammation, acid-base balance, blood coagulation and organ damage following pediatric polytrauma. The early use of relevant laboratory markers may assist decision making on imaging tools, thus contributing to minimize radiation-induced long-term consequences, while improving the outcome of children with multiple trauma.<\/jats:p>","DOI":"10.3389\/fped.2021.622753","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T05:29:42Z","timestamp":1615872582000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research"],"prefix":"10.3389","volume":"9","author":[{"given":"Birte","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Karl","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kalbitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Huber-Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Pressmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/S0140-6736(16)00648-6","article-title":"Global burden of diseases, injuries, and risk factors for young people's health during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"387","author":"Mokdad","year":"2016","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.surg.2017.10.070","article-title":"Evolution of a level I pediatric trauma center: Changes in injury mechanisms and improved outcomes","volume":"163","author":"Schlegel","year":"2018","journal-title":"Surgery."},{"key":"B3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s00113-005-0921-4","article-title":"Injury pattern and clinical course of children with multiple injuries in comparison to adults, Ab 11-year analysis at a clinic of maximum utilization","volume":"108","author":"Gatzka","year":"2005","journal-title":"Unfallchirurg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3389\/fped.2019.00477","article-title":"The Prognostic Value of Troponin in Pediatric Polytrauma","volume":"7","author":"Braun","year":"2019","journal-title":"Front Pediatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.prrv.2013.02.011","article-title":"Management of chest trauma in children","volume":"14","author":"Tovar","year":"2013","journal-title":"Paediatr Respir Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00005373-199601000-00012","article-title":"Pediatric blunt cardiac injury: Epidemiology, clinical features, and diagnosis. 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